Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: Comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties

Braunová, Alena; Chytil, Petr; Laga, Richard; Šírová, Milada; Machová, Daniela; Parnica, Jozef; Řı́hová, Blanka; Janoušková, Olga; Etrych, Tomáš

doi:10.1016/j.jconrel.2020.03.002

Cited by 24 publications

(15 citation statements)

References 52 publications

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“…Recently, our group developed new micellar amphiphilic di‐ or triblock copolymers based on hydrophilic HPMA copolymers and PPO. [ 40,133 ] We also showed that these micelle‐forming copolymers have exhibited an effective chemosensitization in human and murine cancer cell lines overexpressing P‐gp, while exhibiting negligible cytotoxicity. Nevertheless, the presence of free PPO loaded into the micelles forming these block copolymers increased significantly the ability to inhibit the P‐gp function in vitro without any increase in cytotoxicity ( Figure 5 ).…”

Section: Other Macromolecules Acting As Dfmtmentioning

confidence: 89%

Polymer‐Based Drug‐Free Therapeutics for Anticancer, Anti‐Inflammatory, and Antibacterial Treatment

Tavares

Pechar

Chytil

et al. 2021

Macromolecular Bioscience

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This paper summarizes the area of biomedicinal polymers, which serve as nanomedicines even though they do not contain any anticancer or antiinflammatory drugs. These polymer nanomedicines with unique design are in the literature highlighted as a novel class of therapeutics called “drug‐free macromolecular therapeutics.” Their therapeutic efficacy is based on the tailored multiple presentations of biologically active vectors, i.e., peptides, oligopeptides, or oligosaccharides. Thus, they enable, for example, to directly induce the apoptosis of malignant cells by the crosslinking of surface slowly internalizing receptors, or to deplete the efficacy of tumor‐associated proteins. The precise biorecognition of natural binding motifs by multiple vectors on the polymer construct remains the crucial part in the designing of these drug‐free nanomedicines. Here, the rationales, designs, synthetic approaches, and therapeutic potential of drug‐free macromolecular therapeutics consisting of various active vectors are described in detail. Recent developments and achievements for namely B‐cell lymphoma treatment, Gal‐3‐positive tumors, inflammative liver injury, and bacterial treatment are reviewed and highlighted. Finally, a possible future prospect within this highly exciting new field of nanomedicine research is presented.

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Section: Other Macromolecules Acting As Dfmtmentioning

confidence: 89%

Polymer‐Based Drug‐Free Therapeutics for Anticancer, Anti‐Inflammatory, and Antibacterial Treatment

Tavares

Pechar

Chytil

et al. 2021

Macromolecular Bioscience

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“…For attachment of DOX each of the four nanoparticles contained 5 mol % of hydrazide groups alongside the hydrophilic HPMA copolymer that were used for covalent attachment of the DOX via a pHsensitive hydrazone bond in two different cancer models. 22 Models consisted of C57BL/6 (H-2b) female mice that were transplanted subcutaneously with EL4 T cell lymphoma cells and BALB/c (H-2d) mice who were transplanted with CT26 colon carcinoma. Lymphoma bearing mice were given a single dose administration of polymer equivalent to 7.5 mg DOX/kg, while mice with aggressive colon cancer were administered three doses of polymer equivalent to 9 mg DOX/kg.…”

Section: Vectorsmentioning

confidence: 99%

“…In this latest study, star polymers were measured against three alternatively composed polymer vectors. For attachment of DOX each of the four nanoparticles contained 5 mol % of hydrazide groups alongside the hydrophilic HPMA copolymer that were used for covalent attachment of the DOX via a pH-sensitive hydrazone bond in two different cancer models . Models consisted of C57BL/6 (H-2b) female mice that were transplanted subcutaneously with EL4 T cell lymphoma cells and BALB/c (H-2d) mice who were transplanted with CT26 colon carcinoma.…”

Section: Star Polymers As Chemotherapeutic Vectorsmentioning

confidence: 99%

Star Polymer Nanomedicines─Challenges and Future Perspectives

Forgham

Zhu

Qiao

et al. 2022

ACS Appl. Polym. Mater.

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Star polymers are structures composed of multiple functional linear arms covalently connected through a central core. The unique conformation of star polymers, with their tunable side arms and architectural plasticity, makes them well equipped to deliver pharmaceutical drugs and biologicals (peptides, nucleic acids), and design imaging agents. A great deal has been reported on the design and synthesis of star polymers, with several studies demonstrating the possibility for future translation. In this work, we have for the first time performed a review on research published over the last 5-years, focused on the translation of star polymer nanoparticles toward therapeutic application. We discuss all the important potential translational breakthroughs in the field as well as offering a perspective on how the addition of cutting-edge in vitro and in vivo models could provide us with the tools for the successful future clinical translation of star polymer nanoparticles.

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“…HA performance as ligand to promote active targeting, used in several nanodevices, has been shown in different research works. Encouraging results in vitro and in vivo, against melanoma, [ 96 ] breast cancer, [ 97 ] and pulmonary adenocarcinoma cells, [ 98 ] as to aid intravitreal drug administration and delivery for gene therapy in retinal site [ 99 ] and to decrease the immunogenicity due to protein corona, [ 100 ] have demonstrated HA capability to boost antitumor action.…”

Section: Cancer Therapymentioning

confidence: 99%

Advances in Hyaluronic‐Acid‐Based (Nano)Devices for Cancer Therapy

Sala

Fabozzi

Gennaro

et al. 2021

Macromolecular Bioscience

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Cancer is the main cause of fatality all over the world with a considerable growth rate. Many biologically active nanoplatforms are exploited for tumor treatment. Of nanodevices, hyaluronic acid (HA)‐based systems have shown to be promising candidates for cancer therapy due to their high biocompatibility and cell internalization. Herein, surface functionalization of different nanoparticles (NPs), e.g., organic‐ and inorganic‐based NPs, is highlighted. Subsequently, HA‐based nanostructures and their applications in cancer therapy are presented.

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Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: Comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties

Cited by 24 publications

References 52 publications

Polymer‐Based Drug‐Free Therapeutics for Anticancer, Anti‐Inflammatory, and Antibacterial Treatment

Polymer‐Based Drug‐Free Therapeutics for Anticancer, Anti‐Inflammatory, and Antibacterial Treatment

Star Polymer Nanomedicines─Challenges and Future Perspectives

Advances in Hyaluronic‐Acid‐Based (Nano)Devices for Cancer Therapy

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