Polymer scaffold fabrication

Bedell, Matthew L.; Guo, Jason L; Xie, Virginia Y.; Navara, Adam M.; Mikos, Antonios G.

doi:10.1016/b978-0-12-818422-6.00018-6

Cited by 7 publications

(4 citation statements)

References 141 publications

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“…Regarding the viscosity, typical values range from 1500 to 80,000 kPa in the dissolution process, while the concentration of solids ranges from 5 to 40% ( w / w ), and the temperature varies from room temperature to below the boiling point of the solvent ( Figure 4 ) [ 88 , 89 , 90 ]. For example, chitosan/hyaluronic acid films, prepared with an increased concentration of the polymers (35%), formed aggregates; water retention within the film was consequently favored, limiting permeation, and reducing the elasticity and flexibility of the films [ 91 ].…”

Section: Fabricationmentioning

confidence: 99%

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Borbolla-Jiménez,

Peña-Corona,

Farah

et al. 2023

Pharmaceutics

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Wound healing is a complex process that involves restoring the structure of damaged tissues through four phases: hemostasis, inflammation, proliferation, and remodeling. Wound dressings are the most common treatment used to cover wounds, reduce infection risk and the loss of physiological fluids, and enhance wound healing. Despite there being several types of wound dressings based on different materials and fabricated through various techniques, polymeric films have been widely employed due to their biocompatibility and low immunogenicity. Furthermore, they are non-invasive, easy to apply, allow gas exchange, and can be transparent. Among different methods for designing polymeric films, solvent casting represents a reliable, preferable, and highly used technique due to its easygoing and relatively low-cost procedure compared to sophisticated methods such as spin coating, microfluidic spinning, or 3D printing. Therefore, this review focuses on the polymeric dressings obtained using this technique, emphasizing the critical manufacturing factors related to pharmaceuticals, specifically discussing the formulation variables necessary to create wound dressings that demonstrate effective performance.

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Section: Fabricationmentioning

confidence: 99%

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Borbolla-Jiménez,

Peña-Corona,

Farah

et al. 2023

Pharmaceutics

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“…The manufacturing process employed for scaffolds production can also improve drug physicochemical and biopharmaceutical properties that influence bioavailability [ 171 ]. Electrospinning improves the drug’s solubility through the amorphization of the API and the nanofiber’s high surface-to-volume ratio [ 119 ].…”

Section: Bioengineered Thermo-responsive Scaffoldsmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

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Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

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“…In this regard, the process of bioprinting is heavily relying on the deposition of bio-inks into designed shapes generated through computer-aided design (CAD) models and, therefore, the bio-inks need to possess a number of key properties, including printability (i.e., viscoelastic properties), printing fidelity, mechanical integrity, and biocompatibility [ 13 , 14 ]. It is worth noting that in the biomedical field, 3D bioprinting differs in practice from 3D printing [ 15 ]. 3D bioprinting refers to printing using living cells and/or biologically active molecules which are incorporated within the bio-ink.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Bio-Ink Formulations Using Marine-Derived Biomaterials for Three-Dimensional (3D) Bioprinting

Khiari

2024

Marine Drugs

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3D bioprinting is a disruptive, computer-aided, and additive manufacturing technology that allows the obtention, layer-by-layer, of 3D complex structures. This technology is believed to offer tremendous opportunities in several fields including biomedical, pharmaceutical, and food industries. Several bioprinting processes and bio-ink materials have emerged recently. However, there is still a pressing need to develop low-cost sustainable bio-ink materials with superior qualities (excellent mechanical, viscoelastic and thermal properties, biocompatibility, and biodegradability). Marine-derived biomaterials, including polysaccharides and proteins, represent a viable and renewable source for bio-ink formulations. Therefore, the focus of this review centers around the use of marine-derived biomaterials in the formulations of bio-ink. It starts with a general overview of 3D bioprinting processes followed by a description of the most commonly used marine-derived biomaterials for 3D bioprinting, with a special attention paid to chitosan, glycosaminoglycans, alginate, carrageenan, collagen, and gelatin. The challenges facing the application of marine-derived biomaterials in 3D bioprinting within the biomedical and pharmaceutical fields along with future directions are also discussed.

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Polymer scaffold fabrication

Cited by 7 publications

References 141 publications

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Recent Developments in Bio-Ink Formulations Using Marine-Derived Biomaterials for Three-Dimensional (3D) Bioprinting

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