Polymer–silica composite as a carrier of an active pharmaceutical ingredient

Kierys, Agnieszka; Rawski, Michał; Goworek, J.

doi:10.1016/j.micromeso.2014.03.011

Cited by 18 publications

(27 citation statements)

References 42 publications

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“…The extended volume of polymer and copolymer beads following the solvent evaporation indicates that the drug molecules to a large extent prevent the network from collapsing. Similar mechanisms were also observed in other systems presented before [13,57]. Therefore, it may be assumed that drug molecules are spread over the entire HT01 network, and, in the case of HT21, the ibuprofen sodium salt locates mainly in the interior of large mesopores.…”

Section: Swelling Characteristics Of Resinssupporting

confidence: 70%

“…Therefore, each of the newly synthesized resins was employed and tested as a matrix in the synthesis of the polymeredrug conjugates. The proposed idea of the controlled release from the polymer microspheres is not new, as it was reported in the 1960 [29], but it still arouses great interest [13,57].…”

Section: Physicochemical Characterization Of Ibuprofen-loaded Conjugatesmentioning

confidence: 99%

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The release of ibuprofen sodium salt from permanently porous poly(hydroxyethyl methacrylate-co-trimethylolpropane trimethacrylate) resins

Kierys

Grochowicz²,

Kosik

2015

Microporous and Mesoporous Materials

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Section: Swelling Characteristics Of Resinssupporting

confidence: 70%

Section: Physicochemical Characterization Of Ibuprofen-loaded Conjugatesmentioning

confidence: 99%

The release of ibuprofen sodium salt from permanently porous poly(hydroxyethyl methacrylate-co-trimethylolpropane trimethacrylate) resins

Kierys

Grochowicz²,

Kosik

2015

Microporous and Mesoporous Materials

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“…The modification of silica particles leads to better hydrophobic interactions with the polymer and unusual unique properties when compared with unmodified hydrophilic fillers [6,7]. Porous silica materials with the large specific surface area, high pore volume and tunable pore size are of great interest for academia and industry due to their applications in adsorption, catalysis [8,9], separation processes [10], drug, delivery systems [11,12] and gas storage [13, 14.] The possibility of using polymer-silica composites to tailor the textural properties of silica could potentially be of considerable value for new silica applications within the above mentioned fields of interest [15]. The performance of silica materials in many applications requires controlling their morphology and the pore structure.…”

Section: Introductionmentioning

confidence: 99%

Synthetic Strategies towards Silica/Poly (Acrylamide-Co-Acrylic Acid) Composites

Shirsath¹,

Gite²,

Meshram³

2017

MOCR

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Abstract. Herein, we are reporting increased thermal properties and self-sustaining ability of polymer compositions with silica. The composite of poly (acrylamide-co-acrylic acid) [P(AM-co-AA)] with silica created intermolecular interactions. The formation of a composite has confirmed by FTIR spectroscopy, DSC, TGA, and FE-SEM analysis. The silica particles were homogeneously distributed in the P(AM-co-AA). The incorporation of silica particles gives rise to the enhancement of thermal stability due to the strong interactions between silica and poly (acrylamide-co-acrylic acid) polymer. Graphical AbstractKeywords: Poly(acrylamide-co-acrylic acid), silica particles, composite, thermal stability IntroductionPolymer composites have been widely studied over a long period of time and over the past few decades, organic polymer-inorganic oxide filler composites have replaced a lot of the conventional polymers in application fields. They are generally organic polymer composites filled with inorganic fillers. Their properties combine the advantages of the inorganic filler material (i. e., rigidity, thermal stability) and of the organic polymer (i.e., flexibility, ductility, process ability) [1]. In addition to such functionalization, composition can successfully reinforce materials; a characteristic example is natural rubbers reinforced by carbon black and silica for practical utilizing as tire materials. Although the composites strategy is useful for the design of relatively hard functional materials, it is not simple to recognize soft composite materials because of the strong interactions at the interface that decrease the polymer chain mobility [2]. A successful way to improve mechanical properties of a polymer is to create their composites or blend with other polymers that have better mechanical properties for the intended applications [3]. Schmidt et al. synthesised conductive composites of polymer using the biologically active polysaccharide hyaluronic acid (HA) as the dopant in order to create biomaterials for tissue engineering and wound-healing applications [4].Among inorganic oxide fillers, silica particles have received much attention due to their well-defined ordered structure, high surface area, cost-effective production, and the ease of surface modification [5]. In the polymer composition with silica particles, this can improve thermal properties and self-sustaining

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“…The possibility of using polymer-silica composites to tailor the textural properties of silica could potentially be of considerable value for new silica applications within above mentioned fields of interest (Kierys et al 2014;Acosta et al 2014). Many factors influence the formation of siliceous network, including the 3D configuration of SiO 2 tetrahedra.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of the mesostructured polymer-silica composite and silicon dioxide through polymer swelling in silica precursor

2016

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Tetrabutoxysilane (TBOS) transition introduced into the preformed porous polymer was found as an effective method in the preparation of highly porous silica adsorbents. The swelling of the acrylic polymer XAD7HP in TBOS causes the total infiltration of polymer beads by the silica precursor. Transformation of TBOS in aqueous solution at presence of the surfactant (hexadecyltrimethylammonium bromide, CTAB) produces two composite phases: silica-polymer beads and fine silica-CTAB particles. After their calcination, two pure silica phases exhibiting extremely high porosity were obtained. The paper presents the structural properties of the composites and silica materials. All materials were characterized by scanning and transmission electron microscopy (SEM and TEM), the low temperature nitrogen adsorption, X-ray diffraction (XRD) and 29 Si NMR spectroscopy.

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Polymer–silica composite as a carrier of an active pharmaceutical ingredient

Cited by 18 publications

References 42 publications

The release of ibuprofen sodium salt from permanently porous poly(hydroxyethyl methacrylate-co-trimethylolpropane trimethacrylate) resins

The release of ibuprofen sodium salt from permanently porous poly(hydroxyethyl methacrylate-co-trimethylolpropane trimethacrylate) resins

Synthetic Strategies towards Silica/Poly (Acrylamide-Co-Acrylic Acid) Composites

Synthesis of the mesostructured polymer-silica composite and silicon dioxide through polymer swelling in silica precursor

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