Polymer SU-8-Based Microprobes for Neural Recording and Drug Delivery

Altuna, Ane; Berganzo, J.; Fernández, Luís

doi:10.3389/fmats.2015.00047

Cited by 20 publications

(18 citation statements)

References 30 publications

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“…One strategy to inhibit the foreign body reaction is to release anti‐inflammatory drugs in the vicinity of a biosensor. Drug‐releasing polymer layers or microfluidic systems can be integrated into microfabricated probes (Figure ) and biosensors coated with a porous polymer membrane containing anti‐inflammatory pharmaceutical agents have been proposed . Nitric oxide (NO) is a molecule that blocks platelet aggregation and hemostasis, and it also displays anti‐inflammatory and pro‐angiogenic properties that make it a prime candidate for being incorporated into in vivo biosensors to improve biocompatibility .…”

Section: Biocompatibilitymentioning

confidence: 99%

Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

2018

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Chemical analyses of brain interstitial fluid can reveal important information about local brain metabolism and neurochemistry, and can enhance our understanding of how neuronal networks respond to physiological or pathological stimuli. Among brain monitoring methods currently available, microelectrode biosensors provide real‐time analyses with high temporal resolution and minimal perturbation to living tissue by using oxidase enzymes for biological recognition. Two types of microelectrodes are used: cylindrically shaped wire electrodes provide the smallest implantable devices to date, and microfabricated multi‐electrode needles can monitor several molecules simultaneously. They have already contributed significantly to our understanding of brain energy metabolism with glucose and lactate detection, and to neurotransmitter systems with glutamate, D‐serine, acetylcholine, and purine detection. They have the potential to undergo further technological developments in future studies.

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Section: Biocompatibilitymentioning

confidence: 99%

Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

2018

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“…To mitigate cellular and molecular response to the implanted probe, various materials and designs of neural probes and the local delivery of anti-inflammatory drug have been investigated to enhance electrode longevity [ 15 , 16 , 17 , 18 , 19 ]. Some other approaches such as nerve growth factor application or rejuvenation process using electrical pulses may be another useful strategy to prolong the lifetime of chronically implanted microelectrodes [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Some other approaches such as nerve growth factor application or rejuvenation process using electrical pulses may be another useful strategy to prolong the lifetime of chronically implanted microelectrodes [ 20 , 21 , 22 ]. Many researchers have focused on using soft materials to mediate tissue and cell damage from mechanical motion in the brain [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…While silicon and metal probes have traditionally been utilized for neural sensing applications, soft polymer materials may have an advantage due to their greater flexibility and biocompatibility [ 18 , 23 , 24 ]. One major problem that occurs when interfacing neural probes and brain tissue is related to the large difference in Young’s Modulus (10 5 –10 7 Pa) between them [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Computational Assessment of Neural Probe and Brain Tissue Interface under Transient Motion

2016

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The functional longevity of a neural probe is dependent upon its ability to minimize injury risk during the insertion and recording period in vivo, which could be related to motion-related strain between the probe and surrounding tissue. A series of finite element analyses was conducted to study the extent of the strain induced within the brain in an area around a neural probe. This study focuses on the transient behavior of neural probe and brain tissue interface with a viscoelastic model. Different stages of the interface from initial insertion of neural probe to full bonding of the probe by astro-glial sheath formation are simulated utilizing analytical tools to investigate the effects of relative motion between the neural probe and the brain while friction coefficients and kinematic frequencies are varied. The analyses can provide an in-depth look at the quantitative benefits behind using soft materials for neural probes.

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“…For convection enhanced drug delivery purposes, a variety of microdevices has been successfully tested in vivo [15][16][17][18][19]. In our work, we propose an in vivo method of using neural microelectrode with monolithically integrated microfluidic channel to control tracer delivery in the close vicinity of the recording sites by iontophoresis.…”

Section: Introductionmentioning

confidence: 99%

Combined in vivo recording of neural signals and iontophoretic injection of pathway tracers using a hollow silicon microelectrode

Fekete

Pálfi

Márton

et al. 2016

Sensors and Actuators B: Chemical

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Please cite this article as: Z.Fekete, E.Pálfi, G.Márton, M.Handbauer, Zs.Bérces, I.Ulbert, A.Pongrácz, L.Négyessy, Combined in vivo recording of neural signals and iontophoretic injection of pathway tracers using a hollow silicon microelectrode, Sensors and Actuators B: Chemical http://dx.doi.org/10. 1016/j.snb.2015.12.099 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Combined in vivo recording of neural signals and iontophoretic injection of pathway tracers using a hollow silicon microelectrode AbstractThis paper presents the results of in vivo local release of a neuronal tracer, biotinylated dextran amine (BDA) in the rat somatosensory cortex using monolithically integrated microfluidic channel of a silicon neural microelectrode. The tracer injection is controlled by iontophoresis using Pt electrodes in the vicinity of the outlet of the microfluidic channel. Using 3-5 µA, 5-7 s on/off cycle and 15-20 min total injection time the localized injection resulted in clear anterograde and retrograde BDA labeling both within the cortex and in subcortical structures. Anterograde and retrograde labeling revealed the fine details of neuronal processes including dendritic spines and axon terminal-like endings. Injection sites appeared clear lacking any strong diffuse background labeling. Electrophysiological recording performed with the same microdevice immediately after the iontophoresis indicated normal cortical functioning. The results prove that the combination of in vivo multichannel neural recording and controlled tracer injection using a single implanted microdevice is feasible, and therefore it can be a powerful tool for studying the connectome of the brain.

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Polymer SU-8-Based Microprobes for Neural Recording and Drug Delivery

Cited by 20 publications

References 30 publications

Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

Computational Assessment of Neural Probe and Brain Tissue Interface under Transient Motion

Combined in vivo recording of neural signals and iontophoretic injection of pathway tracers using a hollow silicon microelectrode

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