Polymer–surfactant complexes for microencapsulation of vitamin E and its release

Abstract

Microencapsulation of vitamin E directly from oil-in-water (o/w) emulsions was carried out by means of a novel practically relevant approach. For the first time, a preformed polyelectrolyte-surfactant complex (sodium polystyrene sulfonate/dodecyl trimethyl ammonium bromide) was simultaneously used as an electrosteric emulsion stabilizer and as a charged precursor for the following build up of microcapsules. Subsequently, a layer-by-layer technique was applied to emulsions leading to the formation of core-shell microcapsules with oily cores and polyelectrolyte shells. The effect of the complexes on the process of emulsion formation and on the stability and characteristics of the resulting emulsions was investigated by measurements of dynamic and equilibrium interfacial tension, size distribution (DLS) and interfacial charge (zeta-potential). The resulting microcapsules were characterized by confocal laser scanning microscopy (CLSM), Cryo-SEM, size distribution and zeta-potential measurements on each stage of the shell assembly. The release kinetics of vitamin E was monitored during the consecutive steps of the encapsulation procedure using UV-vis spectroscopy and showed the progressive enhancement of sustainability. The developed approach may be promising for the practical use in the cosmetic and food industry.

The Use of Polymer and Surfactants for the Microencapsulation and Emulsion Stabilization

“…Via the kinetics of vitamin E a gradual slowing down of the vitamin E release was observed in each stage of the formation of the capsule shells. As can be seen from Figure 5 the final microcapsules showed a sustained release of vitamin E within at least 80 h [24]. Colloids Interfaces 2018, 1, 3 6 of 14…”

“…Via the kinetics of vitamin E a gradual slowing down of the vitamin E release was observed in each stage of the formation of the capsule shells. As can be seen from Figure 5 the final microcapsules showed a sustained release of vitamin E within at least 80 h [24]. The microencapsulation approach developed is straightforward and economic and could be used for the encapsulation of a variety of bioactive ingredients for cosmetic and food applications The microencapsulation approach developed is straightforward and economic and could be used for the encapsulation of a variety of bioactive ingredients for cosmetic and food applications…”

“…For the formation of a stable emulsion, not only water-soluble polymers and surfactants [21,22,24,28], but also water-soluble polymers and oil soluble surfactants can be used [23]. Previously, the impact of the surface complex formation in sodium dodecyl sulfate (SDS)/poly(allylamine hydrochloride) (PAH) mixtures at the hexane/water interface was observed using the measurements of the interfacial tension and dilational rheological properties.…”

“…Microencapsulation of Vitamin E directly from oil-in-water (10% O/W) emulsions was carried out by means of a novel approach [24] where a preformed polyelectrolyte-surfactant complex (sodium polystyrene sulfonate/dodecyl trimethyl ammonium bromide) was simultaneously used as an electrosteric emulsion stabilizer and as a charged precursor for the following build-up of further layers to form microcapsules. The primary emulsions were obtained by ultrasonication, which occurs via common mechanisms including cavitation and shear [59].…”

Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery

“…These have numerous advantages such as delivery of both hydrophobic and hydrophilic drugs in controlled manner, high drug carrying capacity and better stability for its suitability in systemic and topical drug delivery . Furthermore, owing to the higher surface area‐to‐volume ratio, nanomedicines provide a significant improvement in the pharmacokinetic and biodistribution properties of the therapeutic agents at the desired site of action . Possession of small size favours the high skin interaction and promotes skin permeation and extends circulating time of drug molecules to the targeted site via active targeting .…”