Polymer sutures for simultaneous wound healing and drug delivery – A review

Joseph, Blessy; George, Anne; Gopi, Sreeraj; Kalarikkal, Nandakumar; Thomas, Sabu

doi:10.1016/j.ijpharm.2017.03.041

Cited by 101 publications

(90 citation statements)

References 104 publications

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“…Cellulose derivatives, such as CMC and MC, ethyl cellulose, acetyl cellulose, and hydroxypropyl cellulose have frequently been used to formulate hydrogels, 110 nanoparticles (e.g., nanowhiskers), 111 and nanofibers. 112 Moreover, in combination with other synthetic and natural polymers, such as proteins, 113 in particular gelatin, 114-119 a wide range of applications [120][121][122][123][124][125][126] have been demonstrated for these composite materials as scaffolds for 3D cellular engineering. 127,128 Glycosaminoglycans (GAGs) in the ECM may be mimicked by electrospinning partially sulfated cellulose with gelatin, yielding functional fibrous structures.…”

Section: Gelatin-cellulosementioning

confidence: 99%

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Afewerki

Sheikhi

Kannan

et al. 2018

Bioengineering & Transla Med

309

210

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Gelatin is a promising material as scaffold with therapeutic and regenerative characteristics due to its chemical similarities to the extracellular matrix (ECM) in the native tissues, biocompatibility, biodegradability, low antigenicity, cost‐effectiveness, abundance, and accessible functional groups that allow facile chemical modifications with other biomaterials or biomolecules. Despite the advantages of gelatin, poor mechanical properties, sensitivity to enzymatic degradation, high viscosity, and reduced solubility in concentrated aqueous media have limited its applications and encouraged the development of gelatin‐based composite hydrogels. The drawbacks of gelatin may be surmounted by synergistically combining it with a wide range of polysaccharides. The addition of polysaccharides to gelatin is advantageous in mimicking the ECM, which largely contains proteoglycans or glycoproteins. Moreover, gelatin–polysaccharide biomaterials benefit from mechanical resilience, high stability, low thermal expansion, improved hydrophilicity, biocompatibility, antimicrobial and anti‐inflammatory properties, and wound healing potential. Here, we discuss how combining gelatin and polysaccharides provides a promising approach for developing superior therapeutic biomaterials. We review gelatin–polysaccharides scaffolds and their applications in cell culture and tissue engineering, providing an outlook for the future of this family of biomaterials as advanced natural therapeutics.

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Section: Gelatin-cellulosementioning

confidence: 99%

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Afewerki

Sheikhi

Kannan

et al. 2018

Bioengineering & Transla Med

309

210

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“…These efforts can render successful applications in wound healing, infection control and surgical wound closure. Currently, infections on wounds lead in the worst-case scenario to Surgical Site Infections (SSI) with increased treatment costs, higher hospitalization rate, longer treatment duration, severe morbidity, and mortality [23,24].Polymer, biodegradable surgical sutures are widely used for wound closure [24,25]. Polyglycolic acid (PGA) is a synthetic, multifilamented, braided suture and is absorbed within 60 to 90 days by hydrolysis from the surrounding tissues [24].…”

mentioning

confidence: 99%

“…These properties of PGA are needed for a successful wound healing process but not enough to stop SSI due to bacterial resistance against antibiotics and bactericides [24]. Surgical sutures are a foreign material in the body, and as such cause tissue responses leading to inflammation and further complications [25]. PGA is a multifilament suture, and due to this capillarity offers more surface for microbial attachment compared to monofilament sutures [25].…”

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confidence: 99%

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone-iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc-and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.Pharmaceutics 2020, 12, 361 2 of 36 20,000 related deaths in the United States in 2017 only and remains to be one of the important infection-associated mortality reasons [11,12]. The formation of biofilms on biotic and abiotic surfaces [13] paved the way for biofilm antibiotic tolerance as another major health threat [14,15]. This additional problem hampers the treatment of infections, most often gives rise to chronic infections, in the worst case to therapeutic failure, severe morbidity, and mortality [4]. More than 80% of microbial infections are caused by microbial biofilm formation and pose a severe health risk because treatment with antibiotics remains ineffective [16]. The incidence of chronic wound infections is increasing globally to alarming levels [17]. Chronic wounds are marked by high bacterial colonization and infection rates, which can be treated only by novel therapeutic approaches other than the use of conventional antibiotics [18,19]. Chronic wound tissues can contain microbiomes of complex communities with coexisting fungal and bacterial colonies of different strains within biofilms [20]. According to this inter-kingdom model, fungi like Candida albicans can offer structures for other bacteria (S. aureus, P. aeruginosa, Streptococcus spp., E. faecalis, E. coli, and Acinetobacter baumannii etc.) to attach, form intricate biofilms, and increase the resistance against any ...

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“…PGA has been used in biodegradable sutures from the early 1970s and is FDA-approved (Kaplan et al, 2014). Furthermore, it is used as scaffold material for biomedical applications such as cell-based and cell-free articular cartilage repair (Joseph, George, Gopi, Kalarikkal, & Thomas, 2017;Kreuz et al, 2011;Siclari et al, 2014). The design of a suitable resorbable scaffold requires its proper architecture, degradation time adapted to tissue development, stiffness, and porosity.…”

Section: Design and Biomechanical Propertiesmentioning

confidence: 99%

Meniscus‐shaped cell‐free polyglycolic acid scaffold for meniscal repair in a sheep model

et al. 2019

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Since loss of meniscus is correlated with an increasing risk for osteoarthritis, meniscal scaffolds are proposed as new strategies. Development of a suitable scaffold has to take into account differing meniscus thickness, exposure to compressive and tensile forces combined with high porosity and biocompatibility of the material. After physical testing of three flat scaffolds composed of different modified polyglycolic acid (PGA) fibers, a three‐dimensional meniscus‐shaped PGA‐hyaluronan implant was generated. Micro‐computed tomography showed 90% porosity in the outer area with 50% in the inner area of the implant. Biocompatibility and expression of meniscus typical cartilaginous genes were shown for human meniscus cells cultivated in the implant with 10% human serum or 5% platelet‐rich plasma for 14 days in vitro. The proof‐of‐concept study in sheep demonstrated proteoglycan‐ and collagen type I‐rich repair tissue formation in partial meniscectomy combined with a meniscus‐shaped PGA‐hyaluronan implant after 6 months. In contrast, the control showed nearly no repair tissue formation. Thus, meniscus‐shaped PGA‐hyaluronan implants might be a suitable therapeutic approach to support repair tissue formation in partial meniscectomy.

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Polymer sutures for simultaneous wound healing and drug delivery – A review

Cited by 101 publications

References 104 publications

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

Meniscus‐shaped cell‐free polyglycolic acid scaffold for meniscal repair in a sheep model

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