Polymer water-soluble derivatives of polypeptide antibiotic, gramicidin-S based on reactive copolymers of N-(2-hydroxypropyl) methacrylamide

Solovskij, M. V.; Panarin, E. F.

doi:10.1016/s0168-3659(98)00126-6

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…However, GS is insoluble in water, and exhibits a rather non-specific activity and a high hemolytic activity, which limit its use as an antibiotic for topical applications [126]. To address this problem, Solovskij et al developed water-soluble polymeric derivatives of GS based on HPMA copolymers [127]. HPMA copolymers containing reactive p-nitrophenoxycarbonyl groups were first synthesized.…”

Section: Hpma Copolymers For the Treatment Of Infectious Diseasesmentioning

confidence: 99%

Beyond oncology — Application of HPMA copolymers in non-cancerous diseases☆

Liu

Miller

Wang

2010

Advanced Drug Delivery Reviews

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Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymerdrug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications are also briefly discussed.

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Section: Hpma Copolymers For the Treatment Of Infectious Diseasesmentioning

confidence: 99%

Beyond oncology — Application of HPMA copolymers in non-cancerous diseases☆

Liu

Miller

Wang

2010

Advanced Drug Delivery Reviews

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“…Various biologically active molecules have been conjugated with HPMA copolymers, e.g., low‐molecular‐weight anticancer drugs (discussed below), antimicrobial agents, immunomodulants, proteins, or diagnostic imaging agents . In this review, attention is paid to the synthesis and evaluations of the properties of HPMA copolymer conjugates with anticancer drugs, the most frequently studied biologically active molecules conjugated with polymer–drug delivery systems.…”

Section: Hpma Copolymer‐based Drug Delivery Systems For Cancer Treatmentmentioning

confidence: 99%

HPMA Copolymer–Drug Conjugates with Controlled Tumor‐Specific Drug Release

Chytil

Koziolová

Etrych

et al. 2017

Macromolecular Bioscience

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Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water‐soluble polymer carriers of low‐molecular‐weight drugs and compounds, e.g., cytostatic agents, anti‐inflammatory drugs, or multidrug resistance inhibitors, all covalently bound to a carrier by a biodegradable spacer that enables controlled release of the active molecule to achieve the desired pharmacological effect. Among others, the synthetic polymer carriers based on N‐(2‐hydroxypropyl) methacrylamide (HPMA) copolymers are some of the most promising carriers for this purpose. This review focuses on advances in the development of HPMA copolymer carriers and their conjugates with anticancer drugs, with triggered drug activation in tumor tissue and especially in tumor cells. Specifically, this review highlights the improvements in polymer drug carrier design with respect to the structure of a spacer to influence controlled drug release and activation, and its impact on the drug pharmacokinetics, enhanced tumor uptake, cellular trafficking, and in vivo antitumor activity.

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“…For coupling of antifungal compounds, HPMA, , poly(ethylene glycol), , arabinogalactan, − and dicarboxylated glucose polymers have been used in postpolymerization modification approaches. Activated esters featuring nitrophenol or N -hydroxysuccinimide moieties are essential to bind the drug of choice to a polymeric precursor, respectively .…”

Section: Introductionmentioning

confidence: 99%

“…17 In particular, for cancer therapy, poly(L-glutamic acid) represents a promising alternative candidate to become the first approved polymerdrug conjugate comprising multiple drugs. 18 For coupling of antifungal compounds, HPMA, 19,20 poly-(ethylene glycol), 21,22 arabinogalactan, 23−25 and dicarboxylated glucose polymers 26 have been used in postpolymerization modification approaches. Activated esters featuring nitrophenol or N-hydroxysuccinimide moieties are essential to bind the drug of choice to a polymeric precursor, respectively.…”

Section: ■ Introductionmentioning

confidence: 99%

Caspofungin Functionalized Polymethacrylates with Antifungal Properties

et al. 2020

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We describe the synthesis of hydrophilic poly(poly-(ethylene glycol) methyl ether methacrylate) (PmPEGMA) and hydrophobic poly(methyl methacrylate) (PMMA) caspofungin conjugates by a post-polymerization modification of copolymers containing 10 mol % pentafluorophenyl methacrylate (PFPMA), which were obtained via reversible addition−fragmentation chain transfer copolymerization. The coupling of the clinically used antifungal caspofungin was confirmed and quantified in detail by a combination of 1 H-, 19 Fand diffusion-ordered NMR spectroscopy, UV−vis spectroscopy, and size exclusion chromatography. The trifunctional amine-containing antifungal was attached via several amide bonds to the hydrophobic PMMA, but sterical hindrance induced by the mPEGMA side chains prohibited intramolecular double functionalization. Both polymer−drug conjugates revealed activity against important human-pathogenic fungi, that is, two strains of Aspergillus fumigatus and one strain of Candida albicans (2.5 mg L −1 < MEC < 8 mg L −1 , MIC 50 = 4 mg L −1 ), whereas RAW 264.7 macrophages as well as HeLa cells remained unaffected at these concentrations.

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Polymer water-soluble derivatives of polypeptide antibiotic, gramicidin-S based on reactive copolymers of N-(2-hydroxypropyl) methacrylamide

Cited by 9 publications

References 7 publications

Beyond oncology — Application of HPMA copolymers in non-cancerous diseases☆

Beyond oncology — Application of HPMA copolymers in non-cancerous diseases☆

HPMA Copolymer–Drug Conjugates with Controlled Tumor‐Specific Drug Release

Caspofungin Functionalized Polymethacrylates with Antifungal Properties

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