Polymeric adsorbent for removing toxic proteins from blood of patients with kidney failure

Davankov, V. A.; Павлова, Л. А.; Tsyurupa, M. P.; Brady, James A.; Balsamo, Melissa; Yousha, Eric

doi:10.1016/s0378-4347(99)00554-x

Cited by 83 publications

(40 citation statements)

References 19 publications

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“…The cartridge shows an excellent hemocompatibility [6,7] through coating by hydrophilic substitution of vinyl chains [8]. The flow-dynamic pattern has been characterized in vitro [9]. With ex vivo-testing in whole blood, the plasma levels of ß 2 -microglobulin, tumor necrosis factor alpha, and interleukin 1 beta could be significantly reduced [5,7].…”

Section: Discussionmentioning

confidence: 99%

In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System

Reiter

Bordoni

Dall’Olio³

et al. 2002

Blood Purif

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Background/Aim: Substances in the middle molecular weight range have been shown to play a significant pathogenetic role in as diverse disorders as end-stage renal disease and multiple organ failure. To overcome the limitations in the amount removed by hemofilters, new sorbents with a high biocompatibility are actively being developed. Furthermore, biocompatible sorbents by their nonspecific adsorptive behavior could have great impact on detoxification treatment in exogenous intoxications. We performed an in vitro evaluation of a newly developed highly biocompatible sorbent cartridge (Betasorb^®), examining its adsorptive capacity concerning therapeutic drugs. Methods: Uremic blood spiked with a range of therapeutic drugs was recirculated for 2 h in an in vitro hemoperfusion circuit containing a Betasorb device for hemoperfusion. The drug concentrations before and after the passage of the cartridge were measured, and the total amount removed was calculated. Results: The sorbent showed effective removal of glycopeptide antibiotics, digoxin, theophylline, phenobarbital, phenytoin, carbamazepine, and valproic acid. Moderate removal could be demonstrated for tacrolimus and cyclosporine A; aminoglycosides were removed to a small extent only. Conclusions: Betasorb hemoperfusion shows a potent adsorptive capacity concerning therapeutic drugs (except aminoglycosides) and could be of major value in the treatment of intoxications. On the other hand, drug monitoring and possible adjustments are necessary during Betasorb hemoperfusion to maintain the therapeutic ranges of the drugs in blood.

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Section: Discussionmentioning

confidence: 99%

In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System

Reiter

Bordoni

Dall’Olio³

et al. 2002

Blood Purif

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“…The mesoporous range of the sulfonated DAC beads opens up the possibility of using the beads in protein retention systems (Wang et al 2007;Ettenauer et al 2011). Cellulose membranes initially used as immunosorbents possessed mostly small pores which allowed the passage of excess fluid but blocked the removal of bigger proteins, causing their accumulation in the blood and leading to health problems (Davankov et al 2000).…”

Section: Resultsmentioning

confidence: 99%

Sulfonated nanocellulose beads as potential immunosorbents

et al. 2018

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Herein 2,3-dialdehyde cellulose beads prepared from Cladophora green algae nanocellulose were sulfonated and characterized by FTIR, conductometric titration, elemental analysis, SEM, f-potential, nitrogen adsorption-desorption and laser diffraction, aiming for its application as a potential immunosorbent material. Porous beads were prepared at mild reaction conditions in water and were chemically modified by sulfonation and reduction. The obtained 15 lm sized sulfonated beads were found to be highly charged and to have a high surface area of * 100 m 2 g -1 and pore sizes between 20 and 60 nm, adequate for usage as immunosorbents. After reduction of remaining aldehyde groups, the beads could be classified as non-cytotoxic in indirect toxicity studies with human dermal fibroblasts as a first screening of their biocompatibility. The observed properties make the sulfonated cellulose beads interesting for further development as matrix material in immunosorbent devices.

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“…In this case, solute molecules are separated according to their size by their ability to penetrate the porous network of the beaded sorbent. For targeting middle molecular weight uremic toxins (MW 4-30 kDa), a population of pores between 4 and 10 nm will permit the entrance of these toxins to the adsorbent interior of the bead, while excluding larger proteins, such as albumin (MW 69 kDa, molecular diameter 22.6 nm), from the adsorptive surface [29]. The introduction of ion exchange groups can also significantly increase the affinity of resin sorbents for bilirubin [30] and endotoxin [31].…”

Section: Sorbents: Theory and Practicementioning

confidence: 99%

The Next Step from High-Flux Dialysis: Application of Sorbent Technology

et al. 2002

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The current foci of renal replacement therapy with dialysis are middle molecular weight toxins, consisting of small proteins, polypeptides and products of glycosylation and lipoxygenation. Conventional high-flux dialysis is not efficient at removing these molecules, explaining the increased interest in using sorbents to supplement dialysis techniques. Prototype biocompatible sorbents have been developed and investigated for middle molecule removal; these have been shown, in man, to remove β₂-microglobulin, angiogenin, leptin, cytokines and other molecules, without reducing platelets and leukocytes. Extensive clinical studies are underway to demonstrate the clinical utility and safety of adding routinely a sorbent hemoperfusion device to hemodialysis.

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Polymeric adsorbent for removing toxic proteins from blood of patients with kidney failure

Cited by 83 publications

References 19 publications

In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System

In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System

Sulfonated nanocellulose beads as potential immunosorbents

The Next Step from High-Flux Dialysis: Application of Sorbent Technology

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