Polymeric and Ceramic Nanoparticles: Possible Role in Biomedical Applications

Kaushik, Shikha

doi:10.1007/978-3-030-10614-0_39-1

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…Natural hydrophilic polymers include proteins like gelatin, albumin, lectin, and polysaccharides like alginate, dextran, chitosan, and agarose. Synthetic hydrophobic polymers include the use of polylactic acid (PLA), polylactide-co-glycolic acid (PLGA), polystyrene, poly(caprolactone) (PECL), and polymerized in process poly(isobutylcyanoacrylate) (PICA), polybutylcyanoacrylate, polyhexylcyanoacrylate, and polymethacrylate (PMMA) [76]. Several surface-modified polymers have been used to reduce the nonspecific interaction with serum proteins and uptake by phagocytosis so as to bring about favorable alterations in pharmacokinetic parameters of the drug (as shown in Table 3).…”

Section: Polymer-based Nanoformulationsmentioning

confidence: 99%

Nanotechnology-based antiviral therapeutics

Chakravarty

Vora

2020

Drug Deliv. and Transl. Res.

208

165

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The host immune system is highly compromised in case of viral infections and relapses are very common. The capacity of the virus to destroy the host cell by liberating its own DNA or RNA and replicating inside the host cell poses challenges in the development of antiviral therapeutics. In recent years, many new technologies have been explored for diagnosis, prevention, and treatment of viral infections. Nanotechnology has emerged as one of the most promising technologies on account of its ability to deal with viral diseases in an effective manner, addressing the limitations of traditional antiviral medicines. It has not only helped us to overcome problems related to solubility and toxicity of drugs, but also imparted unique properties to drugs, which in turn has increased their potency and selectivity toward viral cells against the host cells. The initial part of the paper focuses on some important proteins of influenza, Ebola, HIV, herpes, Zika, dengue, and corona virus and those of the host cells important for their entry and replication into the host cells. This is followed by different types of nanomaterials which have served as delivery vehicles for the antiviral drugs. It includes various lipid-based, polymer-based, lipid-polymer hybrid-based, carbon-based, inorganic metal-based, surface-modified, and stimuli-sensitive nanomaterials and their application in antiviral therapeutics. The authors also highlight newer promising treatment approaches like nanotraps, nanorobots, nanobubbles, nanofibers, nanodiamonds, nanovaccines, and mathematical modeling for the future. The paper has been updated with the recent developments in nanotechnology-based approaches in view of the ongoing pandemic of COVID-19.

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Section: Polymer-based Nanoformulationsmentioning

confidence: 99%

Nanotechnology-based antiviral therapeutics

Chakravarty

Vora

2020

Drug Deliv. and Transl. Res.

208

165

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“…Their results highlighted that the presence of Hap nanoparticles in the polymeric matrix enhances the physicochemical properties of the obtained composite scaffolds [30]. In this context, Hap and dextran have been used for the development of polymeric nanoparticles with potential uses in various biomedical applications, such as drug delivery, tissue engineering, dentistry and imaging [31]. Shoba et al, in their work entitled "3D nano-bilayered spatially and functionally graded scaffold impregnated bromelain conjugated magnesium-doped hydroxyapatite nanoparticle for periodontal regeneration" revealed that scaffolds containing magnesiumdoped hydroxyapatite possess an improved antibacterial activity and biocompatibility proving that such materials can be promising candidates for uses in periodontal tissue regeneration [32].…”

Section: Introductionmentioning

confidence: 99%

New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites

Predoi,

Ciobanu,

Iconaru

et al. 2023

Polymers

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The new magnesium-doped hydroxyapatite in dextran matrix (10MgHApD) nanocomposites were synthesized using coprecipitation technique. A spherical morphology was observed by scanning electron microscopy (SEM). The X-ray diffraction (XRD) characterization results show hydroxyapatite hexagonal phase formation. The element map scanning during the EDS analysis revealed homogenous distribution of constituent elements of calcium, phosphor, oxygen and magnesium. The presence of dextran in the sample was revealed by Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of the 10MgHAPD nanocomposites was assessed by in vitro assays using Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus mutans ATCC 25175, Porphyromonas gingivalis ATCC 33277 and Candida albicans ATCC 10231 microbial strains. The results of the antimicrobial assays highlighted that the 10MgHApD nanocomposites presented excellent antimicrobial activity against all the tested microorganisms and for all the tested time intervals. Furthermore, the biocompatibility assays determined that the 10MgHApD nanocomposites did not exhibit any toxicity towards Human gingival fibroblast (HGF-1) cells.

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