Polymeric and inorganic nanoscopical antimicrobial fillers in dentistry

Makvandi, Pooyan; Gu, Jun Ting; Zare‬, Ehsan Nazarzadeh; Ashtari, Behnaz; Moeini, Arash; Tay, Franklin R.; Niu, Li Na

doi:10.1016/j.actbio.2019.09.025

Cited by 165 publications

(116 citation statements)

References 318 publications

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“…The antibacterial and antifungal capability of titanium dioxide (TiO 2 ) nanostructures have been demonstrated in several recent studies. [ 179,180 ] Titanium nanoparticles or compounds are extensively popular as additives in oral administrative drugs and food‐related consumer products, such as food colorant, to improve food quality. For this reason, many studies investigated the cytotoxicity of TiO 2 nanomaterials in the digestive system.…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

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518

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

Self Cite

518

368

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“…Chemical disinfectants are indispensable during root canal treatment. For enhanced control of infection, several nanomaterials have been applied as root canal irrigants such as; metal-based, polymeric, bioactive glass and calcium derivatives nanoparticles, and intracanal medications as well, such as; silver, zinc oxide and chitosan nanoparticles, aiming at good biocompatibility and improving the antimicrobial activity [11,12]. Engineered bioactive chitosan nanoparticles (CSnp) have been shown to effectively inactivate bacterial biofilm and disrupt its extracellular polymeric matrix [13,14].…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm and Immune Response of Engineered Bioactive Nanoparticles for Endodontic Disinfection

Hussein

Kishen

2020

JCM

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The biological aim of root canal treatment is to facilitate periapical tissue healing following endodontic therapy. This study aimed to develop an organotypic infected root canal model to understand the interaction of bacterial biofilm with macrophages and study the therapeutic effect of engineered bioactive chitosan nanoparticles (CSnp) on macrophages. Ex-vivo experiments were conducted in two phases; Phase-1: Enterococcus faecalis biofilms (two and six weeks old) developed in organotypic root canal model were used to characterize residual biofilm after conventional chemical treatment alone and combined with CSnp utilizing Confocal Laser Scanning Microscopy, Scanning Electron Microscopy and colony-forming units from pulverized dentin. Phase-2: The interaction of post-treatment biofilm and RAW macrophages was evaluated regarding pro/anti-inflammatory markers, cell viability and spreading at 24, 48 and 72 h. Compared to conventionally disinfected six-week-old biofilm, CSnp resulted in less viable bacteria (p < 0.01). Scanning electron micrographs demonstrated disruption of the biofilm. CSnp exhibited less residual bacterial load in pulverized dentin (p < 0.001). Macrophage interaction with CSnp-treated biofilm reduced proinflammatory markers (nitric oxide, TNF-α, IL-1β, and IL-6), increased anti-inflammatory marker (TGF-β1) and enhanced cell survival and spreading over time (p < 0.01 at 72 h). Engineered chitosan nanoparticles concurrently inactivated biofilm and altered the inflammatory response of macrophages that would promote healing.

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“…The activity of HybenX ® against S. aureus and E. faecalis appears to be of particular relevance due to the role of these pathogens in some periodontal infections (e.g., chronic and aggressive periodontitis) [13,14]. It could be of interest to compare the activity of HybenX ® with quaternary ammonium compounds and antimicrobial filler nanocompounds, also studied for dentistry applications [15,16]. Moreover, the broad spectrum antibacterial and antifungal activity of HybenX ® could be of interest for possible future uses with non-healing wounds, in epidemiological settings with a high prevalence of multi-drug resistant bacterial strains, or complicated with fungal infections, together with other promising antibacterials, such as silver nanoparticles [17].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens

et al. 2019

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The recent increase in infections mediated by drug-resistant bacterial and fungal pathogens underlines the urgent need for novel antimicrobial compounds. In this study, the antimicrobial activity (inhibitory and cidal) of HybenX ® , a novel dessicating agent, in comparison with commonly used sodium hypochlorite and chlorhexidine, against a collection of bacterial and yeast strains representative of the most common human pathogenic species was evaluated. The minimal inhibitory, bactericidal, and fungicidal concentrations (MIC, MBC, and MFC, respectively) of the three different antimicrobial agents were evaluated by broth microdilution assays, followed by subculturing of suitable dilutions. HybenX ® was active against 26 reference strains representative of staphylococci, enterococci, Enterobacterales, Gram-negative nonfermenters, and yeasts, although at higher concentrations than sodium hypochlorite and chlorhexidine. HybenX ® MICs were 0.39% for bacteria (with MBCs ranging between 0.39% and 0.78%), and 0.1-0.78% for yeasts (with MFCs ranging between 0.78% and 1.6%). HybenX ® exhibited potent inhibitory and cidal activity at low concentrations against several bacterial and yeast pathogens. These findings suggest that HybenX ® could be of interest for the treatment of parodontal and endodontic infections and also for bacterial and fungal infections of other mucous membranes and skin as an alternative to sodium hypochlorite and chlorhexidine.

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Polymeric and inorganic nanoscopical antimicrobial fillers in dentistry

Cited by 165 publications

References 318 publications

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Antibiofilm and Immune Response of Engineered Bioactive Nanoparticles for Endodontic Disinfection

In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens

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