Polymeric and Lipid-Based Materials for Topical Nanoparticle Delivery Systems

Abstract

The delivery of drugs and cosmetic actives to the skin by nanoparticle formulations has a number of advantages over conventional formulations. Nanoparticle formulations offer protection of incorporated active compounds against chemical degradation, more flexibility in modulating the release of the compound, the use of well-tolerated excipients, and feasibility of large scale production. The materials used in the nanoparticle synthesis and formulation can influence product stability, active ingredient properties and delivery to the intended site of action. This review describes the characteristics and application of various polymeric and lipid materials in the preparation of nanoparticles for topical and transdermal drug delivery.

Topical delivery of anti-TNFα siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivo

“…Cap is known to stimulate the release of vasoactive neuropeptides such as substance P and calcitonin gene related peptide from C-fiber nerve terminal in the skin [56]. Park et al demonstrated that Cap significantly inhibited the production of pro-inflammatory cytokine TNFα and also inhibited pro-inflammatory mediators through NF-κB, inactivation [57]. This suggests that Cap has a direct relation in altering the levels of TNFα and NF-κB.…”

Encapsulation of cosmetic active ingredients for topical application – a review

“…Inorganic materials, such as silicates, clays and polyphosphates, can also be used as second polymers. (Pawar et al, 2010;Cattaneo et al, 2010;Pedro et al, 2009;Matsuda et al, 1999;Tarimci et al, 2011;Lee et al, 2012;Wille, 2006) Biopolymers (natural polymers) and biodegradable polymers, such as chitosan and aliphatic polyesters like poly(lactic acid) (PLA) and copolymers of lactic and glycolic acids (e.g. PLGA -poly(lactic co-glycolic acid), are the encapsulating materials with greater interest for applications in the field of skin delivery systems.…”

Comparative Analysis of Sunscreen Nanoencapsulation Processes

“…This might already be expected, as polymer particles are solid and insoluble in water. However, final particle sizes were small, requiring additional amounts of PMMA in the initial load . As a matter of fact, the control of average particle sizes in miniemulsion polymerizations is relatively simple and not very sensitive to the presence of the chemical load, as particles sizes can be modified by the intensity of the emulsification step, amount of emulsifier and viscosity of the dispersed phase …”