Polymeric hydrophilic polymers in targeted drug delivery

Poon, Karen; Castellino, Victor; Cheng, Y-L

doi:10.1533/9781845693077.1.42

Cited by 8 publications

(4 citation statements)

References 215 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The degree of swelling is influenced by the extent of cross-linking and the polymer’s chemical nature. It dictates many of the important properties in the design of hydrogels as drug delivery systems or for any other use [ 28 ]. Figure 5 a and Table 3 show the results obtained in the experiments to determine the swelling rate of the 3D-printed coatings over 120 h. Both types of the 3D-printed coatings (non-functionalised and CLIN-functionalised) show a significant degree of swelling.…”

Section: Resultsmentioning

confidence: 99%

“…Whereas electrospinning is known to produce material with a morphology often resembling 3D printing [ 25 , 26 ], with its reliance on computer-aided-design (CAD) modeling, it enables the preparation of coating with tailorable properties [ 27 ]. Many polymers made from biological sources offer natural hydrophilicity, biocompatibility [ 28 ], biodegradability, and regenerative characteristics (e.g., osteoinduction and osteointegration) [ 29 ], which makes them suitable for drug delivery applications. For this reason, sodium alginate, a water-soluble, non-toxic, and biocompatible linear polysaccharide [ 30 ] and carboxymethylcellulose (CMC), an anionic water-soluble polysaccharide derived from cellulose were chosen as the two dominant polymer components of the coatings.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

et al. 2021

View full text Add to dashboard Cite

This study presents the development and characterisation of two novel bioactive coatings deposited on TiAlV and AISI 316LVM substrates. The coatings were prepared using 3D printing and electrospinning. The 3D-printed coating consisted of the cellulose nanofibril suspension, alginate, and carboxymethylcellulose (CMC), while CMC and polyethylene oxide were used to prepare the electrospun coating. Both coatings were loaded with the antibiotic clindamycin (CLIN), which is a bacteriostatic lincosamide known for its activity against streptococci, staphylococci, pneumococci, Bacteroides species, and other anaerobes. Initial characterisation of the coatings was performed by attenuated total reflectance Fourier transform infrared spectroscopy, field emission scanning electron microscopy, and atomic force microscopy. Furthermore, the contact angle measurements, swelling rate, and biodegradability of the coatings were investigated. The released concentration of CLIN in PBS (pH = 7.4 at 25 °C) was determined by UV-VIS spectrophotometry. The coatings’ biocompatibility was determined using an MTT (3(4,5 dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) assay using an osteoblast cell culture (hFOB 1.19, ATCC CRL 11372).

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

et al. 2021

View full text Add to dashboard Cite

show abstract

“…[36][37][38] Moreover, especially in the case of nanocarriers of anticancer agents, sizes of up to 500 nm are considered to be acceptable, as such nanoparticles are preferentially localized in tumors due to the enhanced permeability and retention (EPR) effect. 39 Furthermore, the prepared nanoparticles exhibited great size stability in PBS, with their mean size diameters being only slightly increased in the order of 10.00 nm after 20 days (Fig. 3b).…”

Section: Synthesis and Characterization Of Mpeg-pcl Nanoparticles Loa...mentioning

confidence: 92%

Pegylated-polycaprolactone nano-sized drug delivery platforms loaded with biocompatible silver(i) complexes for anticancer therapeutics

Varna

Christodoulou

Gounari³

et al. 2022

RSC Med. Chem.

View full text Add to dashboard Cite

show abstract

“…Hydrophilic polymers are often used for hydrogel synthesis due to their biocompatibility [21,22] in aqueous environments [23] and mostly due to their loading drug potential [24].…”

Section: Hydrogel Synthesis Methodsmentioning

confidence: 99%

Hydrogels Based Drug Delivery Synthesis, Characterization and Administration

et al. 2019

View full text Add to dashboard Cite

Hydrogels represent 3D polymeric networks specially designed for various medical applications. Due to their porous structure, they are able to swollen and to entrap large amounts of therapeutic agents and other molecules. In addition, their biocompatibility and biodegradability properties, together with a controlled release profile, make hydrogels a potential drug delivery system. In vivo studies have demonstrated their effectiveness as curing platforms for various diseases and affections. In addition, the results of the clinical trials are very encouraging and promising for the use of hydrogels as future target therapy strategies.

show abstract

Polymeric hydrophilic polymers in targeted drug delivery

Cited by 8 publications

References 215 publications

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

Pegylated-polycaprolactone nano-sized drug delivery platforms loaded with biocompatible silver(i) complexes for anticancer therapeutics

Hydrogels Based Drug Delivery Synthesis, Characterization and Administration

Contact Info

Product

Resources

About