Polymeric membrane electrodes for selective determination of the central nervous system acting drugs fluphenazine hydrochloride and nortriptyline hydrochloride

El‐Ragehy, Nariman A.; El-Kosasy, Amira M.; Abbas, Samah S.; El-khateeb, Sonia Z.

doi:10.1016/s0003-2670(00)00941-7

Cited by 30 publications

(17 citation statements)

References 21 publications

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“…This is in agreement with the literature data [19,20,25,26]. The results obtained with a 2% ion-pair content (TPB or TCPB) for four plasticizers are summarized in Table 3.…”

Section: Influence Of Plasticizer and Sensing Componentsupporting

confidence: 91%

Amodiaquine polymeric membrane electrode

Malongo

Blankert

Kambu

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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“…This is in agreement with the literature data [19,20,25,26]. The results obtained with a 2% ion-pair content (TPB or TCPB) for four plasticizers are summarized in Table 3.…”

Section: Influence Of Plasticizer and Sensing Componentsupporting

confidence: 91%

Amodiaquine polymeric membrane electrode

Malongo

Blankert

Kambu

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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“…[13][14][15][16] Electrochemical methods have been reported. [17,18] It is also determined by a potentiometric titration with 0.1 M sodium hydroxide as reported in British Pharmacopoeia (2000) [1] and European Pharmacopoeia (2000). [19] Fluphenazine hydrochloride is a trifluoromethyl phenothiazine derivative, chemically designated as 2,4-[3-(2-trifluoro-methyl phenothiazine-10-yl) propyl] piperazine-1-yl-ethanol dihydrochloride.…”

Section: Introductionmentioning

confidence: 99%

“…[13,29,30] Electrochemical methods have been recommended. [18,31,32] It is also determined by non-aqueous titration method as reported in British Pharmacopoeia (2000) [1] and European Pharmacopoeia (2000). [19] The present work describes a first derivative of ratio spectra ( 1 DD) for quantitative determination of nortriptyline hydrochloride in presence of fluphenazine hydrochloride, which is used in combination in ''Motival'' tablets.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric and Stability Indicating High Performance Liquid Chromatographic Determination of Nortriptyline Hydrochloride and Fluphenazine Hydrochloride

2002

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Spectrophotometric and high performance liquid chromatographic procedures are described for determination of nortriptyline hydrochloride and fluphenazine hydrochloride. The first procedure is based on application of first derivative of ratio spectra ( 1 DD) for quantitative determination of nortriptyline hydrochloride in presence of fluphenazine hydrochloride. Secondly, an accurate, sensitive and stability indicating method has been introduced for determination of nortriptyline hydrochloride and fluphenazine hydrochloride in both bulk powder and in dosage form. In the derivative ratio method, Beer's law is obeyed in the concentration ranges of 8-32 mg mL À1 and 4-32 mg mL À1 of nortriptyline hydrochloride at wavelengths 271.4 and 284.2 nm, respectively. In high performance liquid chromatographic method, linear relationship in the range of 0.6-3.6 mg mL À1 and 1.2-4.2 mg mL À1 for nortriptyline hydrochloride and fluphenazine hydrochloride, respectively, was obtained. The mobile phase used was 0.05 M ammonium acetate : methanol : acetonitrile (4 : 1 : 5 v/v/v), and detection was done spectrophotometrically at 254 nm. Results were statistically analyzed and compared with those obtained by applying the British Pharmacopoeia (2000) method.

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“…It dissolves the ion associate complexes and adjusts both the membrane permittivity and the ion exchanger site mobility to give the highest possible sensitivity and selectivity. 17 The potential response characteristics of the proposed electrodes were evaluated according to IUPAC recommendations (Table 3). 18 …”

Section: Composition Of the Membranesmentioning

confidence: 99%