Polymeric micellar pH-sensitive drug delivery system for doxorubicin

Hrubý, Martin; Koňák, Čestmı́r; Ulbrich, Karel

doi:10.1016/j.jconrel.2004.11.017

Cited by 356 publications

(278 citation statements)

References 22 publications

Supporting

Mentioning

269

Contrasting

Order By: Relevance

“…Other examples include the polymer-drug conjugate with pH-induced cleavable bonds such as acetal (23,24), hydrozone (25,26), and N-ethoxybenzylimidazole bonds (27). These have been used for cytoplasmic drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin Loaded pH-sensitive Micelle: Antitumoral Efficacy against Ovarian A2780/DOXR Tumor

Kim¹,

Lee²,

Park³

et al. 2008

Pharm Res

107

View full text Add to dashboard Cite

Purpose-To evaluate pH-sensitive mixed micelles for multidrug resistant (MDR) ovarian tumor targeting and optical imaging of solid tumors.Method-Doxorubicin (DOX) encapsulated pH-sensitive mixed micelles composed of poly(Lhistidine) (MW 5K)-b-PEG(MW 2K) and poly(L-lactic acid)(3K)-b-PEG (2K)-folate (PHSM-f) were prepared. Folate receptor-mediated endocytosis, drug uptake, endosomal disruption and cell viability were investigated at the cellular level. For in vivo tumor growth inhibition tests, multidrug resistant ovarian A2780/DOX R xenografted nude mice were used. Optical imaging was performed by using a Cy5.5 fluorescence dye-labeled mixed micelle system. Cy5.5 fluorescence intensity at the tumor site was measured in KB epidermoid xenografted nude mice.Results-In vitro cell viability and drug distribution in the cytoplasm demonstrated the significantly superior efficacy of PHSM-f to free DOX and a control sample of DOX loaded pH-insensitive micelle composed of poly(L-lactic acid)(3K)-b-PEG(2K)/poly(L-lactic acid)(3K)-b-PEG(2K)-folate (80/20 wt/wt%) (PHIM-f). The mechanisms of these results were proved by folate receptor mediated endocytosis of micelle and endosomal disruption function by it. In addition, the optical imaging demonstrated the future application of the diagnositic area. PHSM-f inhibited the growth of multidrug resistant ovarian tumors efficiently in mice, with minimum weight loss.Conclusions-The pH-sensitive mixed micelle system demonstrates effective antitumor efficacy against the multidrug resistant ovarian tumor A2780/DOX R .

show abstract

Section: Introductionmentioning

confidence: 99%

Doxorubicin Loaded pH-sensitive Micelle: Antitumoral Efficacy against Ovarian A2780/DOXR Tumor

Kim¹,

Lee²,

Park³

et al. 2008

Pharm Res

107

View full text Add to dashboard Cite

show abstract

“…In a separate study, Lee et al (32) reported that, PEG-b-polyhistidine micelles containing doxorubicin effectively killed multi-drug resistant MCF-7 cells at pH 6.8. Similarly, Hruby et al, (33) reported that, SDDS can achieve a highly localized drug accumulation at target sites even though it is administered parenterally. It is therefore postulated that, SDDS with enhanced targeting property is highly promising in increasing the efficiency and efficacy of therapy while at the same time minimizing side effects.…”

Section: Smart Drug Delivery Systemsmentioning

confidence: 88%

Nanotechnology in Drug Delivery

Emeje¹,

Obidike²,

Akpabio³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

View full text Add to dashboard Cite

“…The SMA micelle gives the potential to achieve a wide range of drug loading depending on the characteristics privileges, as this parameter will also precondition a slow or a fast release of the drug from the micelle [19][20][21]. This system differs from most micellar sytem engineered where the drug release rate shows pronounced biphasic characteristics [22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Drug Loading on Caveolin-1 Mediated Intracellular Internalization of Doxorubicin Nanomicelles in vitro

Nehoff¹

2014

J Nanomed Nanotechnol

View full text Add to dashboard Cite

Polymeric micellar pH-sensitive drug delivery system for doxorubicin

Cited by 356 publications

References 22 publications

Doxorubicin Loaded pH-sensitive Micelle: Antitumoral Efficacy against Ovarian A2780/DOXR Tumor

Doxorubicin Loaded pH-sensitive Micelle: Antitumoral Efficacy against Ovarian A2780/DOXR Tumor

Nanotechnology in Drug Delivery

The Influence of Drug Loading on Caveolin-1 Mediated Intracellular Internalization of Doxorubicin Nanomicelles in vitro

Contact Info

Product

Resources

About