Polymeric micelles: a ray of hope among new drug delivery systems

Kapse, Anuja; Anup, Neelima; Patel, Vruti; Saraogi, Gaurav K.; Mishra, Dinesh Kumar; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814487-9.00006-5

Cited by 23 publications

(18 citation statements)

References 136 publications

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“…Nanoparticles of amphiphilic block copolymers comprising PLA hydrophobic block and PEG hydrophilic block have been extensively studied as potential vehicles for drug delivery due to their biocompatibility and biodegradability [ 27 , 28 , 29 ]. In aqueous solution, PLA- b -PEG copolymers are able to self-organize into “core-corona” nanosized structures, where hydrophobic PLA block chains form an inner core surrounded by a corona of hydrophilic PEG block chains [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin

et al. 2021

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Nanoparticles based on biocompatible methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (mPEG113-b-P(D,L)LAn) copolymers as potential vehicles for the anticancer agent oxaliplatin were prepared by a nanoprecipitation technique. It was demonstrated that an increase in the hydrophobic PLA block length from 62 to 173 monomer units leads to an increase of the size of nanoparticles from 32 to 56 nm. Small-angle X-ray scattering studies confirmed the “core-corona” structure of mPEG113-b-P(D,L)LAn nanoparticles and oxaliplatin loading. It was suggested that hydrophilic oxaliplatin is adsorbed on the core-corona interface of the nanoparticles during the nanoprecipitation process. The oxaliplatin loading content decreased from 3.8 to 1.5% wt./wt. (with initial loading of 5% wt./wt.) with increasing PLA block length. Thus, the highest loading content of the anticancer drug oxaliplatin with its encapsulation efficiency of 76% in mPEG113-b-P(D,L)LAn nanoparticles can be achieved for block copolymer with short hydrophobic block.

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Section: Introductionmentioning

confidence: 99%

Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin

et al. 2021

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“…A similar trend was observed for EE, except when the micelles were loaded with PTX. In this case, the percentage of EE decreased by 11.7% (from 88.9% to 77.2%) when the D/C ratio increased from 0.2 to 0.3, which can be explained by the limited solubilization capacity of the micelles [36,37]. These results suggested that CouPEG was an excellent carrier for PTX and CUR.…”

Section: Preparation and Characterization Of Drug-loaded Polymeric Mi...mentioning

confidence: 78%

Self-assembled coumarin- and 5-fluorouracil-PEG micelles as multifunctional drug delivery systems

López

Rodríguez‐López

Garcı́a

et al. 2022

Journal of Drug Delivery Science and Technology

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“…The CMC values of SEs are generally one to two magnitudes lower than that of other commercial surfactants. This is advantageous for cleansing products, as the lower the CMC value, the easier it is for the surfactant to form micelles, which increases overall formulation stability [38]. SEs also possess a high foam quality, and are mild, making them especially suitable for preparations such as baby shampoos [39].…”

Section: Sucrose Esters (Ses)mentioning

confidence: 99%

A review on the synthesis of bio-based surfactants using green chemistry principles

2022

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Objectives With increasing awareness of the potential adverse impact of conventional surfactants on the environment and human health, there is mounting interest in the development of bio-based surfactants (which are deemed to be safer, more affordable, are in abundance, are biodegradable, biocompatible and possess scalability, mildness and performance in formulation) in personal care products. Method A comprehensive literature review around alkyl polyglucosides (APGs) and sucrose esters (SEs) as bio-based surfactants, through the lens of the 12 green chemistry principles was conducted. An overview of the use of bio-based surfactants in personal care products was also provided. Results Bio-based surfactants are derived primarily from natural sources (i.e. both the head and tail molecular group). One of the more common types of bio-based surfactants are those with carbohydrate head groups, where alkyl polyglucosides (APGs) and sucrose esters (SEs) lead this sub-category. As global regulations and user mandate for sustainability and safety increase, evidence to further support these bio-based surfactants as alternatives to their petrochemical counterparts is advantageous. Use of the green chemistry framework is a suitable way to do this. While many of the discussed principles are enforced industrially, others have only yet been applied at a laboratory scale or are not apparent in literature. Conclusion Many of the principles of green chemistry are currently used in the synthesis of APGs and SEs. These and other bio-based surfactants should, therefore, be considered suitable and sustainable alternatives to conventional surfactants. To further encourage the use of these novel surfactants, industry must make an effort to implement and improve the use of the remaining principles at a commercial level. Graphical abstract

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Polymeric micelles: a ray of hope among new drug delivery systems

Cited by 23 publications

References 136 publications

Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin

Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin

Self-assembled coumarin- and 5-fluorouracil-PEG micelles as multifunctional drug delivery systems

A review on the synthesis of bio-based surfactants using green chemistry principles

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