Polymeric micelles in mucosal drug delivery: Challenges towards clinical translation

Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

“…22,23 The nanoranged size along with the prolonged circulatory property allows mixed micelles to eventually accumulate in any compromised tissue vasculature sites, eg, tumor via a passive targeting phenomenon commonly referred to as enhanced permeability and retention effect. 20,22,24 Therefore, the overarching aim of the current study was to design a novel AP/TPGS mixed micellar system and investigate its potential targeted therapeutic effect in treating lung cancer in vitro and in vivo. The AP/TPGS mixed micelles of CK could enhance the water solubility and permeability of CK, prolong its retention time, and promote its accumulation in tumor tissues.…”

Recent Advances in Chitosan-Based Nanomedicines for Cancer Chemotherapy

“…Polymeric micelles are another form of nanomedicines formed by the self-aggregation of copolymeric amphiphiles above a certain concentration called critical micellar concentration (CMC) [86]. These micelles usually comprises of copolymers such as X-Y diblocks and X-Y-X triblocks, where X and Y represent the hydrophilic and the hydrophobic blocks, respectively.…”

“…These micelles usually comprises of copolymers such as X-Y diblocks and X-Y-X triblocks, where X and Y represent the hydrophilic and the hydrophobic blocks, respectively. During their synthesis hydrophilic blocks accommodate at the interface between the inner hydrophobic domain composed of the hydrophobic segments, known as core and the external medium, forming the micellar corona which control the release of the drug payload [86][87][88]. Ideally, micelles developed for chemotherapeutic agents must be (i) small enough (10-200 nm) to effectively penetrate into cancer cells; (ii) unrecognizable by the mononuclear phagocyte system (MPS) for a sufficient time in order to accumulate in target tissue; (iii) able to interact with the target cells; (iv) eliminated from the organism either after degradation or dissolution; (v) have tunable stability; (vi) improve the pharmacokinetic (PK) profile of the chemotherapeutic agent; (vii) possess high loading capacity; and (viii) synthesized in a reproducible, facile method which is reasonably inexpensive [89][90][91].…”

Designing polymers with sugar-based advantages for bioactive delivery applications

“…Under the mucosal layer is the glycocalyx, comprised of proteoglycans, glycoproteins, and glycolipids in the cell membrane. An alternative strategy of using sugars to target the mucosal surfaces is to decorate the delivery system exterior with lectins to interact with glycosylated surfaces, such as mucosal surfaces [103]. Studies have evaluated lectinized liposomes in binding to alveolar type II epithelial cells [104] or to intestinal mucosa for oral delivery [105].…”