Polymeric Micro/Nanomotors and Their Biomedical Applications

Liang, Ziying; Tu, Yingfeng; Peng, Fei

doi:10.1002/adhm.202100720

Cited by 19 publications

(7 citation statements)

References 97 publications

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“…The motion behavior of the nanomotors is very favorable for its efficient uptake by cells, − and we next evaluated these properties. First, the capability of the NO/H 2 S SOD/PAC@CSF nanomotors to penetrate human venous endothelial cells (HUVECs) was assessed.…”

Section: Resultsmentioning

confidence: 99%

Chemotactic NO/H₂S Nanomotors Realizing Cardiac Targeting of G-CSF against Myocardial Ischemia-Reperfusion Injury

Huang

Zhang

et al. 2023

ACS Nano

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Recombinant granulocyte colony-stimulating factor (G-CSF), with a direct repair effect on injured cardiomyocytes against myocardial infarction ischemia-reperfusion-injury (IRI), displays a poor effect owing to the limited cardiac targeting efficacy. There are almost no reports of nanomaterials that deliver G-CSF to the IRI site. Herein, we propose a way to protect G-CSF by constructing one layer of nitric oxide (NO)/hydrogen sulfide (H2S) nanomotors on its outside. NO/H2S nanomotors with specific chemotactic ability to high expression of reactive oxygen species (ROS)/induced nitric oxide synthase (iNOS) at the IRI site can deliver G-CSF to the IRI site efficiently. Meanwhile, superoxide dismutase is covalently bound to the outermost part, reducing ROS at the IRI site through a cascade effect with NO/H2S nanomotors. The synergistic effect between NO and H2S on the effective regulation of the IRI microenvironment can not only avoid toxicity caused by excessive concentration of a single gas but also reduce inflammation level and relieve calcium overload, so as to promote G-CSF to play a cardioprotective role.

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Section: Resultsmentioning

confidence: 99%

Chemotactic NO/H₂S Nanomotors Realizing Cardiac Targeting of G-CSF against Myocardial Ischemia-Reperfusion Injury

Huang

Zhang

et al. 2023

ACS Nano

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“…Therefore, different names are given to these micro/nanobots by different research groups. Frequently came across names of these micro/nanobots are microjets, nanorockets, micropropellers, microrobots, nanotrain, microhelices, micro or nano-swimmers, self-propelling microsphere, micro or nano engine etc [10][11][12][13][14][15]. These design strategies paved the pathways for developing application-specific micro/nanobots.…”

Section: Design Strategies and Propulsion Mechanism Of Micro/nanobotsmentioning

confidence: 99%

Strategies in design of self-propelling hybrid micro/nanobots for bioengineering applications

Shivalkar,

Roy,

Chaudhary

et al. 2023

Biomed. Mater.

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Micro/nanobots are integrated devices developed from engineered nanomaterials that have evolved significantly over the past decades. They can potentially be pre-programmed to operate robustly at numerous hard-to-reach organ/tissues/cellular sites for multiple bioengineering applications such as early disease diagnosis, precision surgeries, targeted drug delivery, cancer therapeutics, bio-imaging, biomolecules isolation, detoxification, bio-sensing, and clearing up clogged arteries with high soaring effectiveness and minimal exhaustion of power. Several techniques have been introduced in recent years to develop programmable, biocompatible, and energy-efficient micro/nanobots. Therefore, the primary focus of most of these techniques is to develop hybrid micro/nanobots that are an optimized combination of purely synthetic or biodegradable bots suitable for the execution of user-defined tasks more precisely and efficiently. Recent progress has been illustrated here as an overview of a few of the achievable construction principles to be used to make biomedical micro/nanobots and explores the pivotal ventures of nanotechnology-moderated development of catalytic autonomous bots. Furthermore, it is also foregrounding their advancement offering an insight into the recent trends and subsequent prospects, opportunities, and challenges involved in the accomplishments of the effective multifarious bioengineering applications.

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“…[24] Apart from metal-based motors, photothermal polymer-based microrobots are also promising candidates. [25][26][27][28] Kong and coworkers very recently reported a super-assembled hollow nanomotor with calcinated organosilica-dopamine asymmetric structure, which exhibited great photothermal conversion capacity under NIR irradiation with a surface-functionalized aromatic nucleus. [29] NIR-driven photothermal nano/micromotors have been applied in photothermal therapy, [30] rotary environmental sensors, [31] and bioanalytical applications.…”

Section: Introductionmentioning

confidence: 99%

Multi‐Wavelength Light‐Responsive Metal–Phenolic Network‐Based Microrobots for Reactive Species Scavenging

et al. 2023

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Light‐driven microrobots with different propulsion mechanisms have attracted great attention in microrobot synthesis and applications. However, current systems rely heavily on precious metals, using a complex synthesis process and limited working wavelength. It is therefore of great interest to fabricate microrobots that can be driven by multi‐wavelength irradiation and with simple components. Here, metal–phenolic network (MPN)‐based microrobots are synthesized using a sacrificial polystyrene bead template and an extra capping is added to regulate their symmetry. The hollow MPN microrobots with different layers of capping are capable of moving under both near‐infrared (NIR) irradiation and ultraviolet (UV) irradiation, without fuel. The velocity of the microrobots under irradiation is altered by the thickness of the asymmetric capping and their motion could be manipulated remotely by switching the NIR or UV irradiation on and off. With light‐driven mobility, the reactive oxygen and nitrogen species (RONS) scavenging activity of the microrobots is significantly increased. Therefore, this proposed microrobot system provides a synthesis strategy to develop asymmetric light‐navigated microrobots for future medical treatment with tunable structure, multi‐wavelength light‐responsive mobility, and great RONS scavenging capacity.

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Polymeric Micro/Nanomotors and Their Biomedical Applications

Cited by 19 publications

References 97 publications

Chemotactic NO/H₂S Nanomotors Realizing Cardiac Targeting of G-CSF against Myocardial Ischemia-Reperfusion Injury

Chemotactic NO/H₂S Nanomotors Realizing Cardiac Targeting of G-CSF against Myocardial Ischemia-Reperfusion Injury

Strategies in design of self-propelling hybrid micro/nanobots for bioengineering applications

Multi‐Wavelength Light‐Responsive Metal–Phenolic Network‐Based Microrobots for Reactive Species Scavenging

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Polymeric Micro/Nanomotors and Their Biomedical Applications

Cited by 19 publications

References 97 publications

Chemotactic NO/H2S Nanomotors Realizing Cardiac Targeting of G-CSF against Myocardial Ischemia-Reperfusion Injury

Chemotactic NO/H2S Nanomotors Realizing Cardiac Targeting of G-CSF against Myocardial Ischemia-Reperfusion Injury

Strategies in design of self-propelling hybrid micro/nanobots for bioengineering applications

Multi‐Wavelength Light‐Responsive Metal–Phenolic Network‐Based Microrobots for Reactive Species Scavenging

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Product

Resources

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Chemotactic NO/H₂S Nanomotors Realizing Cardiac Targeting of G-CSF against Myocardial Ischemia-Reperfusion Injury

Chemotactic NO/H₂S Nanomotors Realizing Cardiac Targeting of G-CSF against Myocardial Ischemia-Reperfusion Injury