Polymeric nano-micelles: Versatile Platform for Targeted Delivery in Cancer

Abstract

Polymeric micelles are among the most promising delivery systems in nanomedicine. The growing interest in polymeric micelles as drug delivery vehicle is promoted by the advantages they offer for hydrophobic anticancer agents. The size of most polymeric micelles lies within the range 10-100 nm ensuring that they can selectively leave the circulation at tumor site via the enhanced permeability and retention effect. Their unique structure allows them to solubilize hydrophobic drugs, prolongs their circulatory half-life and eventually leads to enhanced therapeutic efficacy. In addition, they can undergo several structural modifications to further augment tumor cell uptake. In this review, we will discuss various micellar systems that have been studied in preclinical and clinical settings.

The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin

“…4 Nonetheless, passive targeting through EPR effect is still limited in tumor therapy, due to the recognition and clearance by reticuloendothelial system (RES), systemic toxicity, and low delivery efficiency. 5,6 Therefore, active tumor-targeted PMs, which could be internalized by specific receptor-mediated endocytosis in tumor cells, and achieve a higher chemotherapy efficacy and are beneficial in reducing the side effects in normal tissues, have been extensively focused toward cancer treatment. 7,8 To achieve active targeting, various specific targeting ligands, such as folic acid, 9,10 peptide, [11][12][13] hyaluronic acid, [14][15][16] and other ligands, 17 have been grafted onto the surface of PMs, and then the PMs specifically interact with the receptor expressed on target cancer cells.…”

Multistage vector delivery of sulindac and silymarin for prevention of colon cancer

“…In fact, polymeric micelles have frequently been used for the delivery of drugs in preclinical and clinical studies [30]. These nanoparticles are formed through the self-assembly of polymers in an aqueous solution [31], yielding supramolecular structures with hydrophobic cores that permit encapsulation of waterinsoluble drugs. Since polymeric micelles typically exhibit dimensions less than 100 nm, they represent ideal second stage vectors for the MSV, which can be fabricated with pore sizes ranging from 50-150 nm [13].…”

Recent developments in nano micelles as drug delivery system

“…The distinctiveness of the polymeric micelles is that they can encapsulate hydrophobic drugs in the core while the exterior can be re ined correspondingly (Kwon and Okano, 1996;Cabral and Kataoka, 2014). They offer advantages such as facile composition, biocompatible, and considerable ef icacy (Gong et al, 2012), porter for the abjectly-water soluble medication in their hydrophobic core and target speci icity (Mohamed et al, 2014). Nano micelles are expensive and provide rise to toxicity issues (Amirmahani et al, 2017).…”