Polymeric nanoparticle-based nanovaccines for cancer immunotherapy

Zhang, Yongxin; Chen, Jiajing; Shi, Linqi; Ma, Feihe

doi:10.1039/d2mh01358d

Cited by 40 publications

(27 citation statements)

References 214 publications

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“…[80] This strategy was applied to acute myeloid leukemia; it resulted in the induction of leukemia-specific cytotoxic T lymphocytes and the identification of B1-1 peptide as a novel immunogenic tumorassociated antigen. [81] Mice with CT26 tumors were immunized with DCs co-transfected with GM-CSF mRNA and CT26 whole tumor mRNA; the cytotoxic activity of immunized mice was significantly higher than that of the control group. [64] Mu et al reported that among 19 patients with androgen-resistant prostate cancer that were treated with total tumor-derived mRNA loaded DC vaccines, 8 patients progressed, 11 patients were considered to have stable disease, and 13 patients showed a decrease in serum prostate-specific antigen levels.…”

Section: Dcs Pulsed/enveloped With Whole Tumor Rnamentioning

confidence: 96%

“…[ 80 ] This strategy was applied to acute myeloid leukemia; it resulted in the induction of leukemia‐specific cytotoxic T lymphocytes and the identification of B1‐1 peptide as a novel immunogenic tumor‐associated antigen. [ 81 ] Mice with CT26 tumors were immunized with DCs co‐transfected with GM‐CSF mRNA and CT26 whole tumor mRNA; the cytotoxic activity of immunized mice was significantly higher than that of the control group. [ 64 ] Mu et al.…”

Section: Cancer Vaccines Loaded With Part Of Whole Tumor Antigensmentioning

confidence: 99%

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Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Diao

Liu

2023

Advanced Science

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Cancer immunotherapies have improved human health, and one among the important technologies for cancer immunotherapy is cancer vaccine. Antigens are the most important components in cancer vaccines. Generally, antigens in cancer vaccines can be divided into two categories: pre-defined antigens and unidentified antigens. Although, cancer vaccines loaded with predefined antigens are commonly used, cancer vaccine loaded with mixed unidentified antigens, especially whole cancer cells or cancer cell lysates, is a very promising approach, and such vaccine can obviate some limitations in cancer vaccines. Their advantages include, but are not limited to, the inclusion of pan-spectra (all or most kinds of ) antigens, inducing pan-clones specific T cells, and overcoming the heterogeneity of cancer cells. In this review, the recent advances in cancer vaccines based on whole-tumor antigens, either based on whole cancer cells or whole cancer cell lysates, are summarized. In terms of whole cancer cell lysates, the focus is on applying whole water-soluble cell lysates as antigens. Recently, utilizing the whole cancer cell lysates as antigens in cancer vaccines has become feasible. Considering that pre-determined antigen-based cancer vaccines (mainly peptide-based or mRNA-based) have various limitations, developing cancer vaccines based on whole-tumor antigens is a promising alternative.

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Section: Dcs Pulsed/enveloped With Whole Tumor Rnamentioning

confidence: 96%

Section: Cancer Vaccines Loaded With Part Of Whole Tumor Antigensmentioning

confidence: 99%

Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Diao

Liu

2023

Advanced Science

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“…Polymeric NPs are nanosized particles composed of polymeric materials . The PNPs have numerous benefits over conventional antimicrobial agents, including enhanced drug stability, bioavailability, solubility, and sustained release. , They have also been extensively investigated for their anti-biofilm and antibacterial activity . Polymeric NPs can be prepared using several techniques such as solvent evaporation, emulsion, and nanoprecipitation.…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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“…In particular, stimuli-responsive polymeric nanovaccines have become a trend in immunotherapeutic applications due to their excellent targeting capabilities and safety, providing satisfactory biosafety and desirable therapeutic effectiveness. 40 This review aims to present the latest development of stimuli-responsive polymeric nanovaccines used in immunotherapy (Scheme 1). Based on recent research, these polymeric nanovaccines are described and categorized into categories, with a specific emphasis on the distinctive material properties and underlying mechanism toward immunotherapy, including polymeric nanovaccine systems that respond to pH, temperature, redox, photothermal, and ultrasound (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy

Mao

Luo

et al. 2023

ACS Nano

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The development of nanovaccines that employ polymeric delivery carriers has garnered substantial interest in therapeutic treatment of cancer and a variety of infectious diseases due to their superior biocompatibility, lower toxicity and reduced immunogenicity. Particularly, stimuli-responsive polymeric nanocarriers show great promise for delivering antigens and adjuvants to targeted immune cells, preventing antigen degradation and clearance, and increasing the uptake of specific antigen-presenting cells, thereby sustaining adaptive immune responses and improving immunotherapy for certain diseases. In this review, the most recent advances in the utilization of stimulus-responsive polymer-based nanovaccines for immunotherapeutic applications are presented. These sophisticated polymeric nanovaccines with diverse functions, aimed at therapeutic administration for disease prevention and immunotherapy, are further classified into several active domains, including pH, temperature, redox, light and ultrasound-sensitive intelligent nanodelivery systems. Finally, the potential strategies for the future design of multifunctional next-generation polymeric nanovaccines by integrating materials science with biological interface are proposed.

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Polymeric nanoparticle-based nanovaccines for cancer immunotherapy

Abstract: Therapeutic cancer vaccines, which are designed to amplify tumor-specific T cell responses, have been envisioned as one of the most powerful tools for effective cancer immunotherapy. However, increasing the potency,...

Cited by 40 publications

References 214 publications

Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Advances in Nanotechnology for Biofilm Inhibition

Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy

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