Polymeric nanoparticles composed of fatty acids and polyvinylalcohol for topical application of sunscreens

Abstract

Benzophenone-3 (BZP) or oxybenzone is widely used in many cosmetic formulations, such as sunscreen lotions or emulsions, shampoos and hair sprays. The nature of the vehicle used can enhance or block the percutaneous absorption of UV filter. In this work, we hydrophobically modified polyvinylalcohol 10 000 (PVA) with fatty acids (FAs) to obtain PVA-FA derivatives for the preparation of lipophilic polymeric nanoparticles able to prevent BZP movement towards the skin. Synthesized PVA-FA derivatives were confirmed by H1 NMR. Nanoparticles loaded with BZP were prepared using a solvent extraction method. The particle size was monitored by means of dynamic light scattering measurements. In-vitro skin permeation studies were performed.

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

“…These were first found to enhance the skin penetration and absorption of the lipophilic sunscreens such as ethyl hexyl methoxycinnamate, as compared to the traditional oil/water emulsions supplied with emulsifiers [96], or the stratum corneum bio-adhesiveness of padimate O [97], although limited in the industrial applications by the unresolved problem of liposome instability. Nano-emulsifier particles also show the ability to inhibit trans-cutaneous absorption of the systemically toxic and immune-suppressing chemical filters [98]. Major limitations lay in the uncertain regulatory status of many polymers, and the elevated costs of large scale production [98,99].…”

“…Nano-emulsifier particles also show the ability to inhibit trans-cutaneous absorption of the systemically toxic and immune-suppressing chemical filters [98]. Major limitations lay in the uncertain regulatory status of many polymers, and the elevated costs of large scale production [98,99].…”

Wide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers

“…5 Although the technical benefits of using nanoparticles for each particular implementation are clear, the broader impacts of the release of such materials into the environment have yet to be understood. [6][7][8] One concern is the cytotoxicity of these materials.…”

Multiparticulate carriers for sun‐screening agents

“…The OMC-nanoparticles provided partial protection against UV-induced erythema in a manner significantly better than a conventional gel. Polymeric nanoparticles composed of fatty acids and polyvinylalcohol for topical application of oxybenzone were prepared using a solvent extraction method [40]. Titanium dioxide nanoparticles were formed by reaction of an inorganic titanium compound with water or ice to form an aqueous titanium compound that was reacted with a dispersing agent.…”