Polymeric Scaffolds: Design, Processing, and Biomedical Application

Dobrzyński, P.; Pamuła, Elżbieta

doi:10.3390/ijms22094552

Cited by 2 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MicroRNAs are small noncoding RNA molecules that are significant to wound healing mechanisms. MicroRNAs, specifically miR146a, play a significant role in the regulation of inflammatory immune responses of the body by modulating the key inflammatory signals critical for wound healing [34,[38][39][40][41][42]. In persistent chronic wounds, miR146a dysregulation may occur, hindering the wound healing procedure and requiring its supplementation to enhance the process [38,42].…”

Section: Effects On Reducing Inflammation and Modulating The Immunolo...mentioning

confidence: 99%

“…Due to their biomimetic properties, polymeric materials are also utilized as tissue regeneration scaffolds. Polymers can serve as matrices for encapsulating several nanoparticles, medications, and other substances, and as simple support structures [40,54]. Therefore, integrating CeO 2 NPs with other polymeric materials or nanofibers can broaden its application to wound healing by allowing for longer drug release at the wound site and accelerating the wound healing process, improving overall efficiency.…”

Section: Potential Applications Of Ceo 2 Nps In Wound Healingmentioning

confidence: 99%

See 1 more Smart Citation

A Brief Review on Cerium Oxide (CeO2NPs)-Based Scaffolds: Recent Advances in Wound Healing Applications

et al. 2023

View full text Add to dashboard Cite

The process of wound healing is complex and involves the interaction of multiple cells, each with a distinct role in the inflammatory, proliferative, and remodeling phases. Chronic, nonhealing wounds may result from reduced fibroblast proliferation, angiogenesis, and cellular immunity, often associated with diabetes, hypertension, vascular deficits, immunological inadequacies, and chronic renal disease. Various strategies and methodologies have been explored to develop nanomaterials for wound-healing treatment. Several nanoparticles such as gold, silver, cerium oxide and zinc possess antibacterial properties, stability, and a high surface area that promotes efficient wound healing. In this review article, we investigate the effectiveness of cerium oxide nanoparticles (CeO2NPs) in wound healing—particularly the effects of reducing inflammation, enhancing hemostasis and proliferation, and scavenging reactive oxygen species. The mechanism enables CeO2NPs to reduce inflammation, modulate the immunological system, and promote angiogenesis and tissue regeneration. In addition, we investigate the efficacy of cerium oxide-based scaffolds in various wound-healing applications for creating a favorable wound-healing environment. Cerium oxide nanoparticles (CeO2NPs) exhibit antioxidant, anti-inflammatory, and regenerative characteristics, enabling them to be ideal wound healing material. Investigations have shown that CeO2NPs can stimulate wound closure, tissue regeneration, and scar reduction. CeO2NPs may also reduce bacterial infections and boost wound-site immunity. However, additional study is needed to determine the safety and efficacy of CeO2NPs in wound healing and their long-term impacts on human health and the environment. The review reveals that CeO2NPs have promising wound-healing properties, but further study is needed to understand their mechanisms of action and ensure their safety and efficacy.

show abstract

Section: Effects On Reducing Inflammation and Modulating The Immunolo...mentioning

confidence: 99%

Section: Potential Applications Of Ceo 2 Nps In Wound Healingmentioning

confidence: 99%

A Brief Review on Cerium Oxide (CeO2NPs)-Based Scaffolds: Recent Advances in Wound Healing Applications

et al. 2023

View full text Add to dashboard Cite

show abstract

“…These strategies can be adapted to treat radiation-induced tissue damage. Hydrogels, serving as a 3D polymer network rich in water, can provide a humid environment [ 11 ], which is conducive to the wound recovery and regeneration of damaged tissues caused by radiation damage. The structure of hydrogel is usually similar to that of extracellular matrix, showing good histocompatibility [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Use of Hydrogel-Based Materials for Radioprotection

Liu

Ding

et al. 2023

Gels

View full text Add to dashboard Cite

Major causes of the radiation-induced disease include nuclear accidents, war-related nuclear explosions, and clinical radiotherapy. While certain radioprotective drug or bioactive compounds have been utilized to protect against radiation-induced damage in preclinical and clinical settings, these strategies are hampered by poor efficacy and limited utilization. Hydrogel-based materials are effective carriers capable of enhancing the bioavailability of compounds loaded therein. As they exhibit tunable performance and excellent biocompatibility, hydrogels represent promising tools for the design of novel radioprotective therapeutic strategies. This review provides an overview of common approaches to radioprotective hydrogel preparation, followed by a discussion of the pathogenesis of radiation-induced disease and the current states of research focused on using hydrogels to protect against these diseases. These findings ultimately provide a foundation for discussions of the challenges and future prospects associated with the use of radioprotective hydrogels.

show abstract

Polymeric Scaffolds: Design, Processing, and Biomedical Application

Abstract: Tissue engineering is a fascinating and multidisciplinary field of science [...]

Cited by 2 publications

References 14 publications

A Brief Review on Cerium Oxide (CeO2NPs)-Based Scaffolds: Recent Advances in Wound Healing Applications

A Brief Review on Cerium Oxide (CeO2NPs)-Based Scaffolds: Recent Advances in Wound Healing Applications

The Use of Hydrogel-Based Materials for Radioprotection

Contact Info

Product

Resources

About