Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

Phan, Hien; Taresco, Vincenzo; Penelle, Jacques; Couturaud, Benoit

doi:10.1039/d0bm01406k

Cited by 64 publications

(55 citation statements)

References 116 publications

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“…As mentioned before, for such operations another key feature is the ability of the nanocarrier to respond to specific stimuli (e.g., temperature, pH, light, redox potential, reactive oxygen species, enzymes). Therefore, stimuli‐responsive mainly vesicular structures assembled through PISA constitute a notably interesting field of study 98,99,111 . One of the most intriguing features of such particles is that they can undergo order–order and order–disorder transitions in response to the external stimuli, thus altering the packing parameter and the self‐organized morphology post‐synthesis, and eventually leading to transitions between different morphologies 98,99 .…”

Section: Bcp Solution Self‐assemblymentioning

confidence: 99%

“…Therefore, stimuliresponsive mainly vesicular structures assembled through PISA constitute a notably interesting field of study. 98,99,111 One of the most intriguing features of such particles is that they can undergo order-order and orderdisorder transitions in response to the external stimuli, thus altering the packing parameter and the selforganized morphology post-synthesis, and eventually leading to transitions between different morphologies. 98,99 Finally, these nano-objects can even be further stabilized by means of cross-linking, thus ensuring their structural integrity and enhancing their bioapplication capability.…”

Section: Polymerization-induced Self-assemblymentioning

confidence: 99%

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Block copolymer solution self‐assembly: Recent advances, emerging trends, and applications

Karayianni

Pispas

2021

Journal of Polymer Science

130

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The self‐assembly process of block copolymers (BCPs) in solution has been at the focus of extended scientific research over the past several decades owing to the astonishing morphological diversity and attainable complexity of the resulting nanoassemblies, including spheres, cylinders, lamellae, vesicles, and many other complex, bicontinuous or even hierarchical structures. The ever‐increasing sophistication in the development of synthetic chemistry methods and techniques has led to a myriad of available macromolecules with varying chemical compositions, architectures, features, and properties. This assortment of characteristics has led in turn to a plethora of intriguing self‐organized polymeric nanostructures, with countless possible applications in several nanotechnological fields relevant to physics, chemistry, material science, nanomedicine, and biomaterials. The present review aims to illuminate the importance and fascinating potential of BCPs solution self‐assembly by highlighting recent advances and emerging trends in the field, as well as significant application‐oriented progress, through characteristic contemporary examples.

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Section: Bcp Solution Self‐assemblymentioning

confidence: 99%

Section: Polymerization-induced Self-assemblymentioning

confidence: 99%

Block copolymer solution self‐assembly: Recent advances, emerging trends, and applications

Karayianni

Pispas

2021

Journal of Polymer Science

130

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“…Furthermore, PISA is extremely versatile: numerous monomer classes can be polymerized via common controlled/living polymerization techniques [ 29 ] in a range of polymerization media, such as water [ 23 ] and organic solvents [ 24 ]. These undoubted advantages of the PISA process have been utilized to develop polymeric formulations for various applications, including drug delivery [ 30 , 31 ], cell/organelle mimicry [ 32 , 33 , 34 ], oil additives for friction [ 35 ] and viscosity [ 36 , 37 ] modification, chemical sensing [ 38 , 39 ], latex-based films [ 40 ], Pickering emulsifiers [ 41 , 42 ], cryopreservation [ 43 , 44 ], and stem cell storage [ 45 ], among others. Recently, the generality and versatility of PISA have been further demonstrated and have been used for the preparation of protein-, (poly)peptide-, and amino acid-based nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly

2021

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Proteins and peptides, built from precisely defined amino acid sequences, are an important class of biomolecules that play a vital role in most biological functions. Preparation of nanostructures through functionalization of natural, hydrophilic proteins/peptides with synthetic polymers or upon self-assembly of all-synthetic amphiphilic copolypept(o)ides and amino acid-containing polymers enables access to novel protein-mimicking biomaterials with superior physicochemical properties and immense biorelevant scope. In recent years, polymerization-induced self-assembly (PISA) has been established as an efficient and versatile alternative method to existing self-assembly procedures for the reproducible development of block copolymer nano-objects in situ at high concentrations and, thus, provides an ideal platform for engineering protein-inspired nanomaterials. In this review article, the different strategies employed for direct construction of protein-, (poly)peptide-, and amino acid-based nanostructures via PISA are described with particular focus on the characteristics of the developed block copolymer assemblies, as well as their utilization in various pharmaceutical and biomedical applications.

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“…Alternatively, the use of reactive polymers for the polymerization creates a functional anchor to enable post-functionalization of the PISA nanoparticles with drugs such as doxorubicin [ 35 – 36 ]. In a different strategy, drug conjugated monomers can be directly used in the polymerization, eliminating the post-modification step [ 28 , 37 – 39 ].…”

Section: Introductionmentioning

confidence: 99%

Post-functionalization of drug-loaded nanoparticles prepared by polymerization-induced self-assembly (PISA) with mitochondria targeting ligands

Noy¹,

Fan²,

Stenzel³

2021

Beilstein J. Org. Chem.

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Herein, the postfunctionalization of different non-fouling PISA particles, prepared from either poly(oligo ethylene glycol methyl ether methacrylate) (pPEGMA) and the anticancer drug PENAO (4-(N-(S-penicillaminylacetyl)amino)phenylarsenonous acid) or zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) and PENAO were reported. Both PISA particles were reacted with triphenylphosphonium (TPP) as mitochondria targeting units in order to evaluate the changes in cellular uptake or the toxicity of the conjugated arsenic drug. Attachment of TPP onto the PISA particles however was found not to enhance the mitochondrial accumulation, but it did influence overall the biological activity of pMPC-based particles in 2D and 3D cultured sarcoma SW982 cells. When TPP was conjugated to the pMPC PISA particles more cellular uptake as well as better spheroid penetration were observed, while TPP on PEG-based PISA had only little effect. It was hypothesized that TPP on the micelle surface may not be accessible enough to allow mitochondria targeting, but more structural investigations are required to elucidate this.

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Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

Abstract: Stimuli-responsive amphiphilic block copolymers have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, the presence of redox...

Cited by 64 publications

References 116 publications

Block copolymer solution self‐assembly: Recent advances, emerging trends, and applications

Block copolymer solution self‐assembly: Recent advances, emerging trends, and applications

Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly

Post-functionalization of drug-loaded nanoparticles prepared by polymerization-induced self-assembly (PISA) with mitochondria targeting ligands

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