Polymerization-Enhanced Photophysical Performances of AIEgens for Chemo/Bio-Sensing and Therapy

Abstract

AIE polymers have been extensively researched in the fields of OLEDs, sensing, and cancer treatment since its first report in 2003, which have achieved numerous breakthroughs during the years. In comparison with small molecules, it can simultaneously combine the unique advantages of AIE materials and the polymer itself, to further enhance their corresponding photophysical performances. In this review, we enumerate and discuss the common construction strategies of AIE-active polymers and summarize the progress of research on polymerization enhancing luminescence, photosensitization, and room-temperature phosphorescence (RTP) with their related applications in chemo/bio-sensing and therapy. To conclude, we also discuss current challenges and prospects of the field for future development

Organic small-molecule fluorescent probe-based detection for alkali and alkaline earth metal ions in biological systems

“…74 And aggregation-induced emission (AIE) fluorophores (AIEgens) provide a new way for chemical/ biological sensing and imaging as they have the unique property of poor emission in dilute solution while high emission in the aggregated state. 75,76 Gao et al developed an AIE-based probe SA-4CO 2 Na for selective and light-up detection of Ca 2+ in the millimolar range (0.6-3.0 mM). 77 The probe SA-4CO 2 Na has two iminodiacetic acid groups at both ends (Fig.…”

Self-Assembled Nanocomposite DOX/TPOR4@CB[7]4 for Enhanced Synergistic Photodynamic Therapy and Chemotherapy in Neuroblastoma

“…Photodynamic therapy (PDT) is a clinically approved noninvasive therapeutic modality of significant importance [ 10 ]. PDT is regarded as an optimal noninvasive modality that offers precise tumor treatment with simplicity, flexibility, and temporal control [ 11 , 12 , 13 ]. The utilization of photosensitizers (PS) enables the generation of cytotoxic reactive oxygen species (ROS), particularly highly reactive singlet oxygen ( 1 O 2 ), which effectively interacts with adjacent biological macromolecules, thereby inducing cellular apoptosis [ 14 , 15 ].…”

Tuning Photophysical Properties via Positional Isomerization of the Pyridine Ring in Donor–Acceptor-Structured Aggregation-Induced Emission Luminogens Based on Phenylmethylene Pyridineacetonitrile Derivatives

“…However, many organic materials exhibit intense fluorescence emission in dilute solutions, while the emission is severely quenched in the aggregate state. This undesirable aggregation-caused quenching (ACQ) effect has, to a large extent, restricted the applications of organic fluorescence materials in the solid state [ 6 , 7 ]. Fortunately, molecules with aggregation-induced emission (AIE) characteristics, which were first reported in 2001 by Tang’s group, have shown their superiority in terms of strong fluorescent emission and high photostability in the aggregate state [ 8 , 9 , 10 ].…”