Polymerization of Vesicles Composed of <i>N</i>-(4-Vinylbenzoyl)phosphatidylethanolamine

Lawson, Glenn E.; Breen, J. J.; Márquez, Manuel; Singh, and Alok; Smith, Bradley D.

doi:10.1021/la026975+

Cited by 9 publications

(14 citation statements)

References 17 publications

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“…Since the efficiency of pegylated liposomes is less than optimal in vivo , alternate approaches to generate stable liposomes are warranted. Towards these efforts, stabilization of liposomes by using the chemically synthesized photoreactive lipids have been reported recently [38,39]. The light-induced reaction in these liposomes involves photo-crosslinking (light-induced polymerization) under relatively mild conditions and often a water soluble free radical initiator is used to begin this reaction.…”

Section: Light-sensitive Liposomes-backgroundmentioning

confidence: 99%

“…The chemical structures of PEs containing a 3, 5-divinylbenzoyl functionality[39] and N -(4-Vinylbenzoyl) head group [38] are shown in Figure 4. Polymerization in liposomes (prepared from these phospholipids) has been demonstrated to photo-crosslink in the presence of UV light without compromising the activity of entrapped enzymes.…”

Section: Light-sensitive Liposomes-backgroundmentioning

confidence: 99%

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Light-sensitive lipid-based nanoparticles for drug delivery: design principles and future considerations for biological applications

Yavlovich

Smith

Gupta

et al. 2010

Molecular Membrane Biology

155

113

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Radiation-based therapies aided by nanoparticles have been developed since decades, and can be primarily categorized into two main platforms. First, delivery of payload of photo-reactive drugs (photosensitizers) using the conventional nanoparticles, and second, design and development of photo-triggerable nanoparticles (primarily liposomes) to attain light-assisted on-demand drug delivery. The main focus of this review is to provide an update of the history, current status and future applications of photo-triggerable lipid-based nanoparticles (light-sensitive liposomes). We will begin with a brief overview on the applications of liposomes for delivery of photosensitizers, including the choice of photosensitizers for photodynamic therapy, as well as the currently available light sources (lasers) used for these applications. The main segment of this review will encompass the details on the strategies to develop photo-triggerable designer liposomes for their drug delivery function. The principles underlying the assembly of photoreactive lipids into nanoparticles (liposomes) and photo-triggering mechanisms will be presented. We will also discuss factors that limit the applications of these liposomes for in vivo triggered drug delivery and emerging concepts that may lead to the biologically viable photo-activation strategies. We will conclude with our view point on the future perspectives of light-sensitive liposomes in the clinic.

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Section: Light-sensitive Liposomes-backgroundmentioning

confidence: 99%

Section: Light-sensitive Liposomes-backgroundmentioning

confidence: 99%

Light-sensitive lipid-based nanoparticles for drug delivery: design principles and future considerations for biological applications

Yavlovich

Smith

Gupta

et al. 2010

Molecular Membrane Biology

155

113

View full text Add to dashboard Cite

show abstract

“…Polymeric lipids bearing either the photo-reactive head group 33 or the diacetylenic groups in the fatty acyl tail regions 68 have been examined for their potential toxic effects in cell culture systems. In both systems, light treatments had minimal effect of the physico-chemical properties of the vesicles 33,34,35,68 . We have reported that delivery of Piroxicam, an anti-inflammatory agent, to cultured cells by head-group polymerized lipid vesicles was superior to delivery of Piroxicam by non-polymerized vesicles or free drug alone 70 ; future in vivo studies are needed to assess the practical applications of this system.…”

Section: Biological Applications Of Polymeric Lipidsmentioning

confidence: 94%

“…Figure 2(ii, iii) shows the chemical structures of two head-group modified phospholipids containing divinylbenzoyl 33 (Fig. 2ii) and styryl 34 (Fig. 2iii) functionalities.…”

Section: Principles Of Polymerizationmentioning

confidence: 99%

Polymeric Lipid Assemblies as Novel Theranostic Tools

Puri

Blumenthal

2011

Acc. Chem. Res.

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Polymerizable lipids have been used in research and medical applications such as membrane models, imaging platforms, drug delivery systems, vaccine carriers, biosensors, and coating materials. The polymerization of these lipid molecules forms a covalent bond between lipid moieties, which improves the noncovalent interactions that maintain the lipid lamellar phase architecture and increases the stability of the polymerized system. Because such lipid molecules form nanoassemblies with modifiable structures that acquire the stability of polymers following covalent bond formation, these lipids are of considerable interest in the emerging field of theranostics. In this Account, we summarize the biomedical applications of polymerizable lipids (primarily phospholipids) in the context of various nanoplatforms. We discuss stable nanoplatforms, which have been used in a variety of theranostics applications. In addition, we describe methods for assembling triggerable theranostics by combining appropriate nonpolymerizable lipids with polymerizable lipids. Polymeric lipids hold promise as nanotools in the field of medical imaging, targeting, and on-demand drug delivery. Because of their similarity to biological lipids, long-term toxicity issues from polymerizable lipid nanoplatforms are predicted to be minimal. Although the field of polymeric nanocapsules is still in development, intensive efforts are underway to produce systems which could be applied to disease diagnosis and treatment. We envision that nanoimaging platforms coupled with localized drug delivery technology will have a significant impact on cancer therapy and other related diseases. The existing wealth of clinical knowledge both in the photochemistry of imaging agents and/or drugs and modifications of these agents using light will prove valuable in the further development of polymeric theranostic lipid-based nanoparticles.

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“…Photocrosslinking -light induced polymerization -has been used as means to stabilize therapeutic nanocarriers such as liposomes [68,69] and nanocapsules [70]. …”

Section: Light-induced Drug Delivery Systems Based On Photocrosslinkingmentioning

confidence: 99%

Ultraviolet light-mediated drug delivery: Principles, applications, and challenges

Barhoumi

Liu²,

Kohane

2015

Journal of Controlled Release

149

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Polymerization of Vesicles Composed of N-(4-Vinylbenzoyl)phosphatidylethanolamine

Cited by 9 publications

References 17 publications

Light-sensitive lipid-based nanoparticles for drug delivery: design principles and future considerations for biological applications

Light-sensitive lipid-based nanoparticles for drug delivery: design principles and future considerations for biological applications

Polymeric Lipid Assemblies as Novel Theranostic Tools

Ultraviolet light-mediated drug delivery: Principles, applications, and challenges

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