Polymers in the Pharmaceutical Applications - Natural and Bioactive Initiators and Catalysts in the Synthesis of Biodegradable and Bioresorbable Polyesters and Polycarbonates

Olędzka, Ewa; Sobczak, Marcin

doi:10.5772/30698

Cited by 8 publications

(8 citation statements)

References 71 publications

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“…Prodrugs usually include several components: (1) polymeric carrier; (2) API; (3) targeting moiety i.e. , antibodies, sugars, peptides, proteins or oligonucleotides, which are responsible for the selectively deliver of the APIs to the appropriate tissue; (4) solubilizing group, which is responsible for an increased solubility of low solubility or insoluble therapeutic agents [9,14,15,16].…”

Section: Macromolecular Conjugates Of Active Substancesmentioning

confidence: 99%

“…The most promising group are biocompatible and biodegradable polymers (Table 1). They can be readily hydrolyzed into non-toxic and removable products and then excluded by normal metabolic processes [7,15,21].…”

Section: Aliphatic Polyesters As a Carriers Of Therapeutic Agentsmentioning

confidence: 99%

“…They are degraded in vivo by hydrolysis reactions into non-toxic products such as glycolic acid, lactic acid or other compounds that become involved in the tricarboxylic acid cycle and are subsequently excreted as carbon dioxide and water. The kinetics of polyester degradation can be tailored by the modifying their morphologies and hydrophilicities during the synthesis [15,21,22].…”

Section: Aliphatic Polyesters As a Carriers Of Therapeutic Agentsmentioning

confidence: 99%

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Enzymatic Polymerization of Cyclic Monomers in Ionic Liquids as a Prospective Synthesis Method for Polyesters Used in Drug Delivery Systems

Piotrowska

Sobczak

2014

Molecules

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Biodegradable or bioresorbable polymers are commonly used in various pharmaceutical fields (e.g., as drug delivery systems, therapeutic systems or macromolecular drug conjugates). Polyesters are an important class of polymers widely utilized in pharmacy due to their biodegradability and biocompatibility features. In recent years, there has been increased interest in enzyme-catalyzed ring-opening polymerization (e-ROP) of cyclic esters as an alternative method of preparation of biodegradable or bioresorbable polymers. Ionic liquids (ILs) have been presented as green solvents in enzymatic ring-opening polymerization. The activity, stability, selectivity of enzymes in ILs and the ability to catalyze polyester synthesis under these conditions are discussed. Overall, the review demonstrates that e-ROP of lactones or lactides could be an effective method for the synthesis of useful biomedical polymers.

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Section: Macromolecular Conjugates Of Active Substancesmentioning

confidence: 99%

Section: Aliphatic Polyesters As a Carriers Of Therapeutic Agentsmentioning

confidence: 99%

Section: Aliphatic Polyesters As a Carriers Of Therapeutic Agentsmentioning

confidence: 99%

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Enzymatic Polymerization of Cyclic Monomers in Ionic Liquids as a Prospective Synthesis Method for Polyesters Used in Drug Delivery Systems

Piotrowska

Sobczak

2014

Molecules

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“…Biodegradable and/or bioresorbable polyesters form the largest and most promising biomaterial class. This is attested by their widespread use in different medical and pharmaceutical applications, such as surgery or implantology [ 5 , 6 ]. These polymers are optimally suited to stay in the body only as long as they serve their function and then are disappearing without the need of a second surgical intervention [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Matrices Composed of β-cyclodextrin and Biodegradable Polyesters in the Controlled Delivery of Pindolol

et al. 2020

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Polymer-drug conjugates are currently being more widely investigated for the treatment of hypertension. In view of the above, in the first stage of our work, we used nontoxic β-cyclodextrin (β-CD) as effective, simple, inexpensive, and safe for the human body initiator for the synthesis of biocompatible and biodegradable functionalized polymers suitable for the medical and pharmaceutical applications. The obtained polymeric products were synthesized through a ring-opening polymerization (ROP) of ε-caprolactone (CL), d,l-, and l,l-lactide (LA and LLA). The chemical structures of synthesized materials were elucidated based on 1H NMR and solid-state carbon-13 cross-polarization/magic angle spinning nuclear magnetic resonance (13C CP/MAS NMR) analysis, while the incorporation of β-CD molecule into the polymer chain was confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Furthermore, molecular modeling has been applied to investigate the intrachain rigidities and chain architectures for several representative structures. The obtained and thoroughly characterized branched matrices were then used to generate the first β-cyclodextrin/biodegradable polymer/β-blocker conjugate through the successful conjugation of pindolol. The conjugates were fabricated by carbodiimide-mediated coupling reaction. The branched biodegradable materials released the drug in vitro in a sustained manner and without “burst release” and thus have the ability to treat different heart diseases.

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“…A promising example is incorporation of bioactive or biocompatible hormones, peptides, amino acids, lipids and other natural compounds into the polymer chain [9][10][11][12]. Recently, Dong and coworkers investigated the synthesis, crystallization and morphology of six-arm starshaped PCL obtained by the ROP of CL with dipentaerythritol as the initiator in bulk [13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of genistein-containing star-shaped homo- and copolyesters by the ring-opening polymerization

Olędzka

2013

Polym. Bull.

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A novel initiator, naturally occurring in soy, has been developed for a direct synthesis of aliphatic star-shaped homo-and copolyesters. The synthesis is based on one of several known isoflavones, genistein, which has been employed as an initiator of homopolymerization of poly(L-Lactide) or co-initiator of copolymerization of e-caprolactone and L-Lactide with Sn(Oct) 2 as a catalyst. The nontoxic chemicals used allow for an inexpensive and safe for human body facile synthesis of biocompatible functionalized polymers suitable for medical and pharmaceutical applications. The obtained polymers were characterized by 1 H, 13 C NMR, FT-IR, SEC-MALLS and MALDI-TOF MS analysis.

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Polymers in the Pharmaceutical Applications - Natural and Bioactive Initiators and Catalysts in the Synthesis of Biodegradable and Bioresorbable Polyesters and Polycarbonates

Cited by 8 publications

References 71 publications

Enzymatic Polymerization of Cyclic Monomers in Ionic Liquids as a Prospective Synthesis Method for Polyesters Used in Drug Delivery Systems

Enzymatic Polymerization of Cyclic Monomers in Ionic Liquids as a Prospective Synthesis Method for Polyesters Used in Drug Delivery Systems

Development and Evaluation of Matrices Composed of β-cyclodextrin and Biodegradable Polyesters in the Controlled Delivery of Pindolol

Synthesis of genistein-containing star-shaped homo- and copolyesters by the ring-opening polymerization

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