Polymers showing intrinsic antimicrobial activity

Haktanıyan, Meltem; Bradley, Mark

doi:10.1039/d2cs00558a

Cited by 108 publications

(48 citation statements)

References 158 publications

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“…Research into the use of natural (e.g., chitin and chitosan) and synthetic polymers with intrinsic antimicrobial activity for infection control for different applications (health, food, packaging) is well established. [ 101 ]. Cellulose-based materials with lignin or carboxylic functional groups have been proposed to be useful in anti-biofilm engineering [ 102 ].…”

Section: Antimicrobials and Anti-biofilm Strategiesmentioning

confidence: 99%

“…Antimicrobial materials represent an attractive alternative to antimicrobial drugs and can be used to functionalize surfaces without adversely affecting the antimicrobial properties, although antimicrobial efficacy is dependent on the material and pathogen. Research in this area has focused on chemical modification of the materials to optimize physicochemical properties (e.g., solubility) and enhance antimicrobial functionality or exploiting key structural features to generate new antimicrobial materials [ 101 ].…”

Section: Antimicrobials and Anti-biofilm Strategiesmentioning

confidence: 99%

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Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

et al. 2022

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Orthopaedic device implants play a crucial role in restoring functionality to patients suffering from debilitating musculoskeletal diseases or to those who have experienced traumatic injury. However, the surgical implantation of these devices carries a risk of infection, which represents a significant burden for patients and healthcare providers. This review delineates the pathogenesis of orthopaedic implant infections and the challenges that arise due to biofilm formation and the implications for treatment. It focuses on research advancements in the development of next-generation orthopaedic medical devices to mitigate against implant-related infections. Key considerations impacting the development of devices, which must often perform multiple biological and mechanical roles, are delineated. We review technologies designed to exert spatial and temporal control over antimicrobial presentation and the use of antimicrobial surfaces with intrinsic antibacterial activity. A range of measures to control bio-interfacial interactions including approaches that modify implant surface chemistry or topography to reduce the capacity of bacteria to colonise the surface, form biofilms and cause infections at the device interface and surrounding tissues are also reviewed.

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Section: Antimicrobials and Anti-biofilm Strategiesmentioning

confidence: 99%

Section: Antimicrobials and Anti-biofilm Strategiesmentioning

confidence: 99%

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

et al. 2022

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“…Because of the ultralow thickness of these polymer films, the electron-hole pairs are rapidly separated and transported to the electron/ hole-transporting layer by the tunneling effect instead of matching the energy level with perovskite halides, respectively. Differing from inorganic interfacial modifiers, the polymers can be decorated with high-density groups containing S, N and O atoms with lone pair electrons, 11,12 which effectively improves the quality of perovskite films. For example, Liu et al applied 2,5-thiophenedimethylammonium (ThDMA) to twodimensional (2D) Dion-Jacobson (DJ) perovskites and achieved a PCE of 15.75%.…”

Section: Introductionmentioning

confidence: 99%

A trifunctional polyethylene oxide buffer layer for stable and efficient all-inorganic CsPbBr₃perovskite solar cells

et al. 2023

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“… 30 − 32 Chitosan derivatives have exhibited their bactericidal action against biofilms of S. aureus and S. mutants . 33 , 34 Although the exact mechanism of highly efficacious antibacterial activity of chitosan is yet to be understood, it is well known that the antibacterial activity of chitosan is based on a number of intrinsic and extrinsic factors. 35 Intrinsic factors include the molecular weight and degree of deacetylation of parent chitosan, size and concentration of nanocarriers, etc.…”

Section: Introductionmentioning

confidence: 99%

Efficient Synergistic Antibacterial Activity of α-MSH Using Chitosan-Based Versatile Nanoconjugates

Barman

Chakraborty²,

Saha³

et al. 2023

ACS Omega

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The application of antimicrobial peptides has emerged as an alternative therapeutic tool to encounter against multidrug resistance of different pathogenic organisms. α-Melanocyte stimulating hormone (α-MSH), an endogenous neuropeptide, is found to be efficient in eradicating infection of various kinds of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA). However, the chemical stability and efficient delivery of these biopharmaceuticals (i.e., α-MSH) to bacterial cells with a significant antibacterial effect remains a key challenge. To address this issue, we have developed a chitosan-cholesterol polymer using a single-step, one-pot, and simple chemical conjugation technique, where α-MSH is loaded with a significantly high amount (37.7%), and the final product is obtained as chitosan-cholesterol α-MSH polymer–drug nanoconjugates. A staphylococcal growth inhibition experiment was performed using chitosan-cholesterol α-MSH and individual controls. α-MSH and chitosan-cholesterol both show bacterial growth inhibition by a magnitude of 50 and 79%, respectively. The killing efficiency of polymer–drug nanoconjugates was very drastic, and almost no bacterial colony was observed (∼100% inhibition) after overnight incubation. Phenotypic alternation was observed in the presence of α-MSH causing changes in the cell structure and shape, indicating stress on Staphylococcus aureus. As a further consequence, vigorous cell lysis with concomitant release of the cellular material in the nearby medium was observed after treatment of chitosan-cholesterol α-MSH nanoconjugates. This vigorous lysis of the cell structure is associated with extensive aggregation of the bacterial cells evident in scanning electron microscopy (SEM). The dose-response experiment was performed with various concentrations of chitosan-cholesterol α-MSH nanoconjugates to decipher the degree of the bactericidal effect. The concentration of α-MSH as low as 1 pM also shows significant inhibition of bacterial growth (∼40% growth inhibition) of Staphylococcus aureus. Despite playing an important role in inhibiting bacterial growth, our investigation on hemolytic assay shows that chitosan-cholesterol α-MSH is significantly nontoxic at a wide range of concentrations. In a nutshell, our analysis demonstrated novel antimicrobial activity of nanoparticle-conjugated α-MSH, which could be used as future therapeutics against multidrug-resistant Staphylococcus aureus and other types of bacterial cells.

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Polymers showing intrinsic antimicrobial activity

Abstract: This article covers the structures and mechanistic modes of action of intrinsic antimicrobial polymers against bacteria, viruses, or fungi including as surface coatings, for example on medical devices, or directly as antimicrobial agents.

Cited by 108 publications

References 158 publications

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

A trifunctional polyethylene oxide buffer layer for stable and efficient all-inorganic CsPbBr₃perovskite solar cells

Efficient Synergistic Antibacterial Activity of α-MSH Using Chitosan-Based Versatile Nanoconjugates

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Polymers showing intrinsic antimicrobial activity

Abstract: This article covers the structures and mechanistic modes of action of intrinsic antimicrobial polymers against bacteria, viruses, or fungi including as surface coatings, for example on medical devices, or directly as antimicrobial agents.

Cited by 108 publications

References 158 publications

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

A trifunctional polyethylene oxide buffer layer for stable and efficient all-inorganic CsPbBr3perovskite solar cells

Efficient Synergistic Antibacterial Activity of α-MSH Using Chitosan-Based Versatile Nanoconjugates

Contact Info

Product

Resources

About

A trifunctional polyethylene oxide buffer layer for stable and efficient all-inorganic CsPbBr₃perovskite solar cells