Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy

Mannose-mediated nanodelivery of methotrexate to macrophages augments rheumatoid arthritis therapy

“…22 To devise M1M-targeting anti-RA therapeutics, mannose-functionalized MTX-loaded polymersomes (Man-PMTX) were facilely produced from PEG-P (TMC-DTC)-sp and Man-PEG-P(TMC-DTC) at various molar ratios (90/10, 80/20 and 70/30) via self-assembly and spontaneous disulfide-crosslinking of the membrane. 11,23 The molecular weight and end-group functionalization of the copolymers were determined by 1 H NMR spectroscopy (Fig. S1 and S2 †) by comparing the integral of TMC (δ 2.08), DTC (δ 3.02), spermine (δ 2.55-2.70) and mannose (δ 4.75-4.90) with that of PEG (δ 3.62), yielding the copolymers with the prescribed molecular weight and nearly quantitative spermine or mannose functionality.…”

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

“…[91][92][93] Agonists of STING and TLR, as well as inhibitors of indoleamine-2,3-dioxygenase (IDO), have been incorporated into the nanoscale delivery system, contributing to evading immune escape or potentiating ICI-based antitumor immune response for RT. 94,95 3. They deliver ICIs and cytokines.…”

The Crucial Roles and Research Advances of cGAS-STING Pathway in Cutaneous Disorders

“…Based on CDNs and nanoparticles, several other delivery systems were designed, called STING-NPs (STING-activating nanoparticles), STING-LNP (lipid nanoparticle containing STING agonist), CPs-CDN (CDN-loaded chimeric polymersomes), and CDN-PEG-lipids (CDNs conjugated to PEGylated lipids), respectively [ 53 , 72 , 113 , 114 ]. Meanwhile, all of the above delivery systems efficaciously promoted STING activation and penetration of tumors, markedly induced tumor repression, and significantly enhanced the anti-melanoma therapy [ 53 , 72 , 113 , 114 ].…”