Polymersomes with inhomogeneous membranes, asymmetrical coronas and fused membranes and coronas

Chen, Shuai; Sha, Lin; Xi, Yuejing; Xiao, Yufen; Du, Jianzhong

doi:10.1360/tb-2020-0472

Cited by 7 publications

(2 citation statements)

References 42 publications

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“…Polymer vesicles and micelles, for instance, are noteworthy . Polymer vesicles are nanometer-sized, hollow spheres with hydrophilic coronas and bilayer (or interdigitated) membranes, in contrast to polymer micelles which possess a solid core. − Their robust and stable characteristics render them suitable for on-demand drug delivery. , Du et al described a polymer vesicle comprised of poly(ethylene oxide)-block-poly[2-(diethylamino)ethyl methacrylate-stat-2-tetrahydrofuranyloxy)ethyl methacrylate], which exhibited significant size reduction upon ultrasound irradiation because of quick rupture and recombination of their membrane . Recent studies have utilized the hydrophobic membranes and hydrophilic coronas of polymer vesicles as distinct modules for simultaneous delivery of chlorin e6 (Ce6) and manganese dioxide (MnO 2 ), showcasing high catalase-like activity and efficient ROS generation upon ultrasound activation (Figure e, f) .…”

Section: Synthesis and Construction Of Ultrasound-based Micro-/nanosy...mentioning

confidence: 99%

Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Huang,

Zheng,

Chang

et al. 2024

Chem. Rev.

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Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed as a physical tool for versatile biomedical applications. Especially, the prosperity of nanotechnology and nanomedicine invigorates the landscape of ultrasound-based medicine. The unprecedented surge in research enthusiasm and dedicated efforts have led to a mass of multifunctional micro-/nanosystems being applied in ultrasound biomedicine, facilitating precise diagnosis, effective treatment, and personalized theranostics. The effective deployment of versatile ultrasound-based micro-/nanosystems in biomedical applications is rooted in a profound understanding of the relationship among composition, structure, property, bioactivity, application, and performance. In this comprehensive review, we elaborate on the general principles regarding the design, synthesis, functionalization, and optimization of ultrasound-based micro-/nanosystems for abundant biomedical applications. In particular, recent advancements in ultrasound-based micro-/nanosystems for diagnostic imaging are meticulously summarized. Furthermore, we systematically elucidate state-of-the-art studies concerning recent progress in ultrasound-based micro-/nanosystems for therapeutic applications targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular diseases, and metabolic diseases. Finally, we conclude and provide an outlook on this research field with an in-depth discussion of the challenges faced and future developments for further extensive clinical translation and application.

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Section: Synthesis and Construction Of Ultrasound-based Micro-/nanosy...mentioning

confidence: 99%

Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Huang,

Zheng,

Chang

et al. 2024

Chem. Rev.

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“…Polymer vesicles and micelles are generally self-assembled from amphiphilic block copolymers [97][98][99]. Polymer vesicles are hollow nanometer-sized spheres with a bilayer or interdigitated membrane and hydrophilic coronas [100][101][102], whereas polymer micelles consist of a solid core instead of a lumen. The stable and robust properties of these nanoparticles make them suitable for controlled drug delivery [103,104].…”

Section: Polymeric Vesicles/micellesmentioning

confidence: 99%

Ultrasound-responsive polymer-based drug delivery systems

Wei

Cornel

2021

Drug Deliv. and Transl. Res.

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108

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Ultrasound-responsive polymeric materials have received a tremendous amount of attention from scientists for several decades. Compared to other stimuli-responsive materials (such as UV-, thermal-, and pH-responsive materials), these smart materials are more applicable since they allow more efficient drug delivery and targeted treatment by fairly non-invasive means. This review describes the recent advances of such ultrasound-responsive polymer-based drug delivery systems and illustrates various applications. More specifically, the mechanism of ultrasound-induced drug delivery, typical formulations, and biomedical applications (tumor therapy, disruption of blood-brain barrier, fighting infectious diseases, transdermal drug delivery, and enhanced thrombolysis) are summarized. Finally, a perspective on the future research directions for the development of ultrasound-responsive polymeric materials to facilitate a clinical translation is given.

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