Polymethoxyflavone purified from<i>Kaempferia parviflora</i>reduces visceral fat in Japanese overweight individuals: a randomised, double-blind, placebo-controlled study

Yoshino, Satoshi; Tagawa, Takashi; Awa, Riyo; Ogasawara, Jun; Kuwahara, Hiroshige; Fukuhara, Ikuo

doi:10.1039/d0fo01217c

Cited by 9 publications

(4 citation statements)

References 35 publications

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“…KP was able to inhibit fat accumulation and muscle atrophy [35], improve physical fitness and muscular endurance [36], and improve energy metabolism by activating brown adipose tissue [37] in mice models. The KP extract was also able to improve physical fitness, heart rate and oxygen consumption in a randomized doubleblind trial [38,39], reduce body fat [40] and the polymethoxyflavones from KP were found to reduce visceral fat area and subcutaneous fat area in another randomised, double-blind, placebo-controlled trial [41]. These reports fall parallel to the point that both KP and DMF could improve the healthspan.…”

Section: Discussionmentioning

confidence: 93%

DAF-16 and SKN-1 mediate Anti-aging and Neuroprotective efficacies of “thai ginseng” Kaempferia parviflora Rhizome extract in Caenorhabditis elegans

Prasanth

Malar

Brimson

et al. 2022

Nutrition and Healthy Aging

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BACKGROUND: The rhizomes of Kaempferia parviflora (KP), have been traditionally used for treating various ailments with 5,7-dimethoxyflavone (DMF) as a prominent compound. OBJECTIVE: To investigate the anti-aging and neuroprotective properties of KP and DMF in Caenorhabditis elegans. METHODS: C. elegans (wild-type (N2), transgenic and mutant strains) were treated with KP and DMF and were monitored for lifespan and neuroprotection through physiological assays, fluorescence microscopy and qPCR analysis. Molecular docking studies were employed to identify the interaction mode of DMF with DAF-16 and SKN-1. RESULTS: KP and DMF significantly increased the lifespan of N2 along with modulating pharyngeal pumping and lipofuscin accumulation. They also exhibited neuroprotection in Aβ transgenic strains by improving lifespan and delaying paralysis. Further, they reduced ROS accumulation significantly in worms exposed to UV-A, thereby exhibiting anti-photoaging potential. KP and DMF could activate SKN-1, DAF-16 which was evident from molecular docking and qPCR analysis. The DAF-2 and DAF-16 mutants did not exhibit any variations in lifespan upon treatment with KP and DMF suggesting the involvement of the DAF-16 mediated pathway in regulating the anti-aging and neuroprotective effects. CONCLUSION: Our findings suggest that KP with DMF as an active ingredient is a potential nutraceutical for aging and associated disorders.

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Section: Discussionmentioning

confidence: 93%

DAF-16 and SKN-1 mediate Anti-aging and Neuroprotective efficacies of “thai ginseng” Kaempferia parviflora Rhizome extract in Caenorhabditis elegans

Prasanth

Malar

Brimson

et al. 2022

Nutrition and Healthy Aging

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“…The anti-obesity effect of KP rhizome extract was reported in several experimental animals, including obese rats induced by high-fat diet (HFD) ( 24 ) and high-fat and high-sugar diet ( 25 ), and in type 2 diabetes model mice ( 23 ). The oral administration of KP rhizome extract was also reported to have an anti-obesity effect in healthy ( 24 , 26 ) and obese people ( 27 ).…”

Section: Popular Scientific Summarymentioning

confidence: 99%

Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL/6N mice

Lee,

Jeon,

Awa

et al. 2023

Food & Nutrition Research

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Kaempferia parviflora (KP) rhizome, also called black ginger, has been used as a herbal medicine for many centuries. This current study was aimed at exploring whether KP rhizome extract (KPE) had anti-obesity effects and the mechanism involved. Five-week-old C57BL/6N male mice were allocated into five groups for 8-week feeding with control diet (CD), high-fat diet (HFD), HFD + 150 mg/kg body weight (BW)/day KPE (HFD+K150), HFD + 300 mg/kg BW/day KPE (HFD+K300), and HFD + 600 mg/kg BW/day KPE (HFD+K600). KPE decreased BW, body fat mass, adipose tissue weight, adipocyte size, and serum levels of glucose, triglycerides, cholesterol, insulin, and leptin in HFD-induced obese C57BL/6N mice. KPE inhibited adipogenesis by decreasing CCAAT/enhancer binding protein α, peroxisome proliferator-activated receptor γ, sterol regulatory element-binding protein-1c, acetyl-CoA carboxylase 1, ATP-citrate lyase, and fatty acid synthase mRNA expression. KPE improved lipolysis by increasing carnitine palmitoyl transferase 1 and hormone-sensitive lipase mRNA expression. These results suggest that KPE may have inhibited HFD-induced obesity by regulating several pathways involved in decreasing adipogenesis and enhancing lipolysis. Thus, the results suggest that KPE (or KP) may be applicable as an anti-obesity agent.

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“…ex Baker or black ginger is a medicinal plant from the Zingiberaceae family that is grown in Southeast Asia 1 . Its rhizomes are used in traditional medicine and have been proven to have various pharmacological activities, including anti‐inflammation, 2–4 anti‐cholinesterase, 5 anti‐allergenic, 6 anti‐cancer, 7–9 anti‐obesity, 1,10–12 anti‐skin aging, 13,14 vasorelaxation 15,16 and sexual enhancing effects 17,18 . Based on morphological characteristics, K. parviflora can be divided into two main types according to the leaf margin color: the red‐leaf and green‐leaf types 19,20 .…”

Section: Introductionmentioning

confidence: 99%

“…ex Baker or black ginger is a medicinal plant from the Zingiberaceae family that is grown in Southeast Asia. 1 Its rhizomes are used in traditional medicine and have been proven to have various pharmacological activities, including antiinflammation, [2][3][4] anti-cholinesterase, 5 anti-allergenic, 6 anti-cancer, [7][8][9] anti-obesity, 1,[10][11][12] anti-skin aging, 13,14 vasorelaxation 15,16 and sexual enhancing effects. 17,18 Based on morphological characteristics, K. parviflora can be divided into two main types according to the leaf margin color: the red-leaf and green-leaf types.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of methoxyflavones discriminates between the two types of Kaempferia parviflora

Polpanich

Susantikarn

Kongkachana

et al. 2022

Phytochemical Analysis

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Introduction: Kaempferia parviflora or black ginger is abundantly cultivated because its rhizomes contain methoxyflavones that have many pharmacological properties.K. parviflora can be divided into two types, based on morphological characteristics, but differences in their chemical compositions have never been explored.Objectives: This research aims to find chemical markers that can be used to differentiate between the two types of K. parviflora, the red-leaf and green-leaf types, by quantifying the amounts of methoxyflavones.Material and methods: K. parviflora samples were collected from 39 locations in Thailand. Their genetic diversity was assessed by a genotyping-by-sequencing (GBS) technique to construct the population structure. Their chemical compositions were analyzed by high performance liquid chromatography-photodiode array detection to determine the methoxyflavone contents. Results:The population structure based on >3,000 single nucleotide polymorphism (SNP) markers showed that the samples can be divided into two groups, which were consistent with the classification by leaf margin color (red-leaf and green-leaf types). HPLC analysis revealed 3,5,7,3 0 ,4 0 -pentamethoxyflavone (PMF), 5,7dimethoxyflavone (DMF), 5,7,4 0 -trimethoxyflavone (TMF), 3,5,7-trimethoxyflavone and 3,5,7,4 0 -tetramethoxyflavone as major methoxyflavones that can be used as chemical markers. The red-leaf type showed higher amounts of PMF, TMF and 3,5,7,4 0 -tetramethoxyflavone than the green-leaf type, while the green-leaf type showed higher amounts of DMF and 3,5,7-trimethoxyflavone than the red-leaf type. Conclusion:These results provide another approach to discriminate the two types of K. parviflora using chemical profiles alongside genetic and morphological analyses.Therefore, a specific type of K. parviflora can be selected over the other based on preferences for a certain methoxyflavone.

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Polymethoxyflavone purified fromKaempferia parviflorareduces visceral fat in Japanese overweight individuals: a randomised, double-blind, placebo-controlled study

Abstract: Visceral fat is a more important factor in obesity-associated disorders in Japanese individuals than in Caucasian individuals.

Cited by 9 publications

References 35 publications

DAF-16 and SKN-1 mediate Anti-aging and Neuroprotective efficacies of “thai ginseng” Kaempferia parviflora Rhizome extract in Caenorhabditis elegans

DAF-16 and SKN-1 mediate Anti-aging and Neuroprotective efficacies of “thai ginseng” Kaempferia parviflora Rhizome extract in Caenorhabditis elegans

Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL/6N mice

Quantitative analysis of methoxyflavones discriminates between the two types of Kaempferia parviflora

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