Polymicrobial Anaerobic Bacteremia Caused by <i>Butyricimonas virosa</i> and <i>Brachyspira pilosicoli</i> in a Patient with Peritonitis following Intestinal Perforation

Ogawa, Yoshihiko; Sato, Masatoshi; Yamashita, T.; Nakano, Ryuichi; Mochizuki, Seibu; Kasahara, Kei; Yano, Hisakazu; Mikasa, Keiichi

doi:10.3343/alm.2018.38.1.71

Cited by 13 publications

(10 citation statements)

References 10 publications

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“…Benzbromarone treatment, conversely, uniquely caused a decrease of the genus Butyricimonas . Previous research has reported Butyricimonas as an infectious bacterium in the intestinal tract ( Ogawa et al, 2018 ). Moreover, the alterations in the functions of the gut microbiota may explain different mechanisms of reducing UA between allopurinol and benzbromarone.…”

Section: Discussionmentioning

confidence: 99%

Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats

Liu

et al. 2018

Front. Microbiol.

103

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Hyperuricaemia is an important risk factor for many diseases including gout, hypertension, and type II diabetes. The gut microbiota is associated with hyperuricaemia and has also been demonstrated to play significant roles in the effects of drug therapy. This study used Illumina MiSeq sequencing to explore alterations of the gut microbiome associated with allopurinol and benzbromarone treatment in the male rat with hyperuricaemia. After drug treatment, both allopurinol and benzbromarone caused an increase of the genera Bifidobacterium and Collinsella and a decrease of the genera Adlercreutzia and Anaerostipes. In addition, allopurinol and benzbromarone caused respective unique changes in genera. The genera Bilophila, Morganella, and Desulfovibrio specifically decreased due to allopurinol treatment. Decreased Butyricimonas and Ruminococcus and increased Proteus were caused by benzbromarone treatment. The PICRUST analysis indicated that allopurinol renovated the disorder of nucleotide metabolism and benzbromarone renovated the disorder of lipid metabolism in the gut microbiota of male rats with hyperuricaemia. These findings demonstrated that the gut microbiota may be altered by the treatment of hyperuricaemia with allopurinol and benzbromarone in male rats. Such alterations of the gut microbiota could be considered as indicators of the effectiveness of drug therapy.

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Section: Discussionmentioning

confidence: 99%

Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats

Liu

et al. 2018

Front. Microbiol.

103

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“…Enterococcus species such as E. faecalis have been reported to promote the virulence of coinfecting organisms (Kao and Kline, 2019) and to promote intestinal inflammation by impairing epithelial barrier integrity (Steck et al ., 2011). Butyricimonas species such as B. virosa have been associated with bacteremia during polymicrobial infection (Ogawa et al ., 2018). Bacteroides species such as B. acidifaciens have been reported to improve metabolic disorders in mice by activating PPAR signalling (Yang et al ., 2017).…”

Section: Discussionmentioning

confidence: 99%

Probiotic Lactobacillus casei Shirota prevents acute liver injury by reshaping the gut microbiota to alleviate excessive inflammation and metabolic disorders

Ren

Wang

et al. 2021

Microbial Biotechnology

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Millions of people die from liver diseases annually, and liver failure is one of the three major outcomes of liver disease. The gut microbiota plays a crucial role in liver diseases. This study aimed to explore the effects of Lactobacillus casei strain Shirota (LcS), a probiotics used widely around the world, on acute liver injury (ALI), as well as the underlying mechanism. Sprague Dawley rats were intragastrically administered LcS suspensions or placebo once daily for 7 days before induction of ALI by intraperitoneal injection of D-galactosamine (D-GalN). Histopathological examination and assessments of liver biochemical markers, inflammatory cytokines, and the gut microbiota, metabolome and transcriptome were conducted. Our results showed that pretreatment with LcS reduced hepatic and intestinal damage and reduced the elevation of serum gamma-glutamyltranspeptidase (GGT), total bile acids, IL-5, IL-10, G-CSF and RANTES. The analysis of the gut microbiota, metabolome and transcriptome showed that LcS lowered the ratio of Firmicutes to Bacteroidetes; reduced the enrichment of metabolites such as chenodeoxycholic acid, deoxycholic acid, lithocholic acid, D-talose and N-acetyl-glucosamine, reduce the depletion of D-glucose and L-methionine; and alleviated the downregulation of retinol metabolism and PPAR signalling and the upregulation of the pyruvate metabolism pathway in the liver. These results indicate the promising prospect of using LcS for the treatment of liver diseases, particularly ALI.

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“…Anaerobes such as Bacteroides spp. and Clostridium spp account for 30-50% of those cases [5]. Anaerobic bacteremia, accounting for 4% of all bacteremia cases at the HSJDM, are mostly originated from endogenous microbiome, often associated with a source of abdominal infection [2], especially in patients with malignancies (particularly colonic cancer).…”

Section: Case Reportmentioning

confidence: 99%

“…Butyricimonas virosa is a prevalent inhabitant of the intestine [1,5]. Few cases of human cases of infection due to B. virosa have been reported in literature [2][3][4][5][6], all of which were bacteremia cases, and three of them were associated with gastrointestinal tumors. On the case we report, the patient had an advanced colon malignancy (see Table ).…”

Section: Case Reportmentioning

confidence: 99%

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First bacteremia described by Butyricimonas virosa in Spain

Gasós¹,

Sigüenza²,

Monzón³

et al. 2019

Med Case Rep Rev

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In the present document, we describe the case of bacteremia caused by Butyricimonas virosa (B. virosa), the first reported in Spain, occurred in a patient affected by colon adenocarcinoma. The literature is reviewed and we summarize the characteristics of the previously described cases, pointing out the fact that B. virosa is closely related to intra-abdominal pathology, especially with gastrointestinal malignancy.

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Polymicrobial Anaerobic Bacteremia Caused by Butyricimonas virosa and Brachyspira pilosicoli in a Patient with Peritonitis following Intestinal Perforation

Cited by 13 publications

References 10 publications

Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats

Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats

Probiotic Lactobacillus casei Shirota prevents acute liver injury by reshaping the gut microbiota to alleviate excessive inflammation and metabolic disorders

First bacteremia described by Butyricimonas virosa in Spain

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