Polymicrobial Q Fever and Enterococcal Aortic Prosthetic Valve Endocarditis with Aortic Root Abscess

Yahav, Dafna; Kuznitz, Israel; Reisfeld, Sharon; Eliakim‐Raz, Noa; Bishara, Jihad

doi:10.1089/vbz.2015.1777

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…Laboratory signs can consist of a persistent inflammatory syndrome and hyperleukocytosis or, on the contrary, pancytopenia (539,545). Cases of coinfection with Enterococcus faecalis, Streptococcus mitis, and Streptococcus gallolyticus have been reported (415,(546)(547)(548).…”

Section: Clinical Manifestationsmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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Section: Clinical Manifestationsmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…All described cases had coinfection with a typical endocarditis-causing pathogen: Streptococcus, Enterococcus , and Staphylococcus spp. Aortic root abscess formation was reported in only one other case ( Yahav et al, 2015 ).…”

Section: Discussionmentioning

confidence: 97%

“…Polymicrobial endocarditis relating to Q fever is rarer. To our knowledge, there are only 11 cases of dual-pathogen Q fever endocarditis reported to date, all outside Australasia ( Kaech et al, 2008 ;Kampschreur et al, 2011 ;Raoult et al, 2005 ;Rovery et al, 2009 ;Yahav et al, 2015 ). All described cases had coinfection with a typical endocarditis-causing pathogen: Streptococcus, Enterococcus , and Staphylococcus spp.…”

Section: Discussionmentioning

confidence: 97%

Culture-negative polymicrobial chronic Q fever prosthetic valve infective endocarditis utilizing 16S ribosomal RNA polymerase chain reaction on explanted valvular tissue

Garg

Chan

Peeceeyen

et al. 2022

International Journal of Infectious Diseases

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“…Polymicrobial endocarditis relating to Q fever is even rarer [ 30 , 31 ]. All described cases had coinfection with a typical endocarditis-causing pathogen: Streptococcus , Enterococcus , and Staphylococcus spp.…”

Section: Discussionmentioning

confidence: 99%

A Dual-Pathogen Mitral Valve Endocarditis Caused by Coxiella burnetii and Streptococcus gordonii—Which Came First?

Kaemmerer,

Ciotola,

Geißdörfer

et al. 2023

Pathogens

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Infective endocarditis (IE) is still a life-threatening disease with high morbidity and mortality. While usually caused by a single bacterium, poly-microbial infective endocarditis (IE) is rare. Here, we report a (blood-culture-negative) dual pathogen mitral valve IE caused by Coxiella burnetii and Streptococcus gordonii: A 53-year-old woman was presented to an internal medicine department with abdominal pain for further evaluation. Within the diagnostic work up, transthoracic echocardiography (TTE) revealed an irregularly shaped echogenic mass (5 × 13 mm) adherent to the edge of the posterior mitral valve leaflet and protruding into the left atrium. As infected endocarditis was suspected, blood cultures were initially obtained, but they remained negative. Chronic Q fever infection was diagnosed using serologic testing. After the occurrence of cerebral thromboembolic events, the patient was admitted for mitral valve surgery. Intraoperatively, a massively destructed mitral valve with adhering vegetations was noted. Examination of the mitral valve by broad-range bacterial polymerase chain reaction (PCR) and amplicon sequencing confirmed Coxiella burnetii infection and yielded Streptococcus gordonii as the second pathogen. Based on the detailed diagnosis, appropriate antibiotic therapy of both pathogens was initiated, and the patient could be discharged uneventfully on the 11th postoperative day after a successful minimal-invasive mitral valve replacement.

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Polymicrobial Q Fever and Enterococcal Aortic Prosthetic Valve Endocarditis with Aortic Root Abscess

Cited by 8 publications

References 18 publications

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

Culture-negative polymicrobial chronic Q fever prosthetic valve infective endocarditis utilizing 16S ribosomal RNA polymerase chain reaction on explanted valvular tissue

A Dual-Pathogen Mitral Valve Endocarditis Caused by Coxiella burnetii and Streptococcus gordonii—Which Came First?

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