Polymorphic calcium alginate microfibers assembled using a programmable microfluidic field for cell regulation

Abstract

<p>Effectively guiding and accurately controlling cell adhesion and growth on the surface of specific morphological materials are key issues and hot research directions for optimizing biomaterials. Herein, novel polymorphic alginate...</p>

Tailoring micro/nano-fibers for biomedical applications

“…Besides, microfibers with more complicated configurations have been fabricated using microfluidic spinning [ [103] , [104] , [105] ]. For example, Huang et al fabricated microfibers with curvature-adjustable morphology through programming flow and reaction kinetics in microchannel [ 106 ]. Inspired by natural silkworms spinning and their hierarchical fiber structure, Guo et al generated multicomponent microfibers with double carbon nanotubes cores and polyurethane shells using a multi-channel co-flow microfluidic device.…”

Microfluidic fabrication of tunable alginate‐based microfibers for the stable immobilization of enzymes

“…[8,[12][13][14][15][16][17][18][19][20][21][22] Microfluidic technique is a promising approach to manufacturing customizable structures by integrating with rapid crosslinking strategies. [18,21,[23][24][25][26][27] The convergence of the emerging microfluidic technology and materials science enables novel applications in various fields including enzyme immobilization. [12,13,21] Alginate is a natural biomaterial widely used in the encapsulation of proteins/enzymes, drugs, and cells due to the capability of rapid crosslinking by multivalent cations (e.g., Ca 2+ or Ba 2+ ).…”

Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation

“…1−3 Fibers have been successfully used across a variety of fields, including electronics, cosmetics, pharmaceutical research, biomedical engineering, and tissue engineering. 4 For instance, fibers have been used for cell regulation studies, 5 for the manufacturing of muscle-like tissues, 6 or for drugrelease studies. 7,8 Microfluidics has played a pivotal role in facilitating production of fibers with controllable and homogeneous properties, compared to the most classic bulk techniques.…”

“…Fibers have seen an exponential growth in their use thanks to the advancement of micro/nanofabrication technologies. − Fibers have been successfully used across a variety of fields, including electronics, cosmetics, pharmaceutical research, biomedical engineering, and tissue engineering . For instance, fibers have been used for cell regulation studies, for the manufacturing of muscle-like tissues, or for drug-release studies. , …”