Polymorphic Regions in Fc Gamma Receptor and Tumor Necrosis Factor‐α Genes and Susceptibility to Chronic Periodontitis in a Cohort From South India

Lavu, Vamsi; Venkatesan, Vettriselvi; Lakkakula, Bhaskar Vks; Sriram, Damal Kandadai; Kumarasamy, P.; Paul, Solomon F.D.; Rao, Suresh Ranga

doi:10.1902/jop.2016.150743

Cited by 10 publications

(7 citation statements)

References 45 publications

(55 reference statements)

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“…Nevertheless, comparison with other ethnically diverse populations unveils clear characteristic features of the FCGR locus in native South Americans (Supplementary Tables 1 and 3). Of note, we could confirm the high frequency of both CNR1 duplication and the FCGR3B-NA1 haplotype, previously reported in this geographical region (2,47,48,52,56). The increased FCGR3B copy-number, concomitant to CNR1 duplication, possibly confers augmented neutrophil adhesion and immune complex uptake; similarly, common finding of the higheractivity CD16B-HNA-1a variant could derive from selective pressures favouring immune complex clearance by high phagocytosis variants, most probably related to infectious disease burden, as previously suggested (2,55).…”

supporting

confidence: 89%

“…−120T) (Figure 3 and Supplementary Table 3). Finally, the FCGR3B-NA1 haplotype more common in South Americans and Asians than in Europeans and Africans (4,5,29,31,(47)(48)(49)(50)(51), shows its highest frequency in Llano Grandeall individuals carried at least one copy; and none of them presented the FCGR3B-SH haplotype (Figure 3).…”

Section: Unique Distribution Of Fcgr Genetic Variations In An Ecuadorian Population From Llano Grandementioning

confidence: 99%

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FCGR Genetic Variation in Two Populations From Ecuador Highlands—Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene

Moraru¹,

Pérez-Portilla

Sanz³

et al. 2021

Front. Immunol.

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Fcγ receptors (FcγR), cell-surface glycoproteins that bind antigen-IgG complexes, control both humoral and cellular immune responses. The FCGR locus on chromosome 1q23.3 comprises five homologous genes encoding low-affinity FcγRII and FcγRIII, and displays functionally relevant polymorphism that impacts on human health. Recurrent events of non-allelic homologous recombination across the FCGR locus result in copy-number variation of ~82.5 kbp-long fragments known as copy-number regions (CNR). Here, we characterize a recently described deletion that we name CNR5, which results in loss of FCGR3A, FCGR3B, and FCGR2C, and generation of a recombinant FCGR3B/A gene. We show that the CNR5 recombination spot lies at the beginning of the third FCGR3 intron. Although the FCGR3B/A-encoded hybrid protein CD16B/A reaches the plasma membrane in transfected cells, its possible natural expression, predictably restricted to neutrophils, could not be demonstrated in resting or interferon γ-stimulated cells. As the CNR5-deletion was originally described in an Ecuadorian family from Llano Grande (an indigenous community in North-Eastern Quito), we characterized the FCGR genetic variation in two populations from the highlands of Ecuador. Our results reveal that CNR5-deletion is relatively frequent in Llano Grande (5 carriers out of 36 donors). Furthermore, we found a high frequency of two strong-phagocytosis variants: the FCGR3B-NA1 haplotype and the CNR1 duplication, which translates into an increased FCGR3B and FCGR2C copy-number. CNR1 duplication was particularly increased in Llano Grande, 77.8% of the studied sample carrying at least one such duplication. In contrast, an extended haplotype CD16A-176V – CD32C-ORF+2B.2 – CD32B-2B.4 including strong activating and inhibitory FcγR variants was absent in Llano Grande and found at a low frequency (8.6%) in Ecuador highlands. This particular distribution of FCGR polymorphism, possibly a result of selective pressures, further confirms the importance of a comprehensive, joint analysis of all genetic variations in the locus and warrants additional studies on their putative clinical impact. In conclusion, our study confirms important ethnic variation at the FCGR locus; it shows a distinctive FCGR polymorphism distribution in Ecuador highlands; provides a molecular characterization of a novel CNR5-deletion associated with CD16A and CD16B deficiency; and confirms its presence in that population.

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confidence: 89%

Section: Unique Distribution Of Fcgr Genetic Variations In An Ecuadorian Population From Llano Grandementioning

confidence: 99%

FCGR Genetic Variation in Two Populations From Ecuador Highlands—Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene

Moraru¹,

Pérez-Portilla

Sanz³

et al. 2021

Front. Immunol.

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“…A total of 2,763 studies were identified from Medline and Scopus, and 1,934 studies remained after removing duplicates. Of these, 1,878 studies were ineligible for reasons described in Figure , leaving 56 that were eligible for review. Six studies were excluded because of insufficient data after contacting the authors.…”

Section: Resultsmentioning

confidence: 99%

“…Of the remaining 50 studies, 45 objectively assessed OH using an oral examination. Of these 45 studies, 15 analysed OH as categorical data, 31 as continuous data and one as both. Eleven studies provided the association between periodontitis and oral care habits measured according to the frequency of brushing, interdental cleaning and dental visits.…”

Section: Resultsmentioning

confidence: 99%

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The association between oral hygiene and periodontitis: a systematic review and meta-analysis

Lertpimonchai

Rattanasiri

Vallibhakara

et al. 2017

International Dental Journal

239

185

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ObjectiveDental plaque accumulation and inadequate personal oral hygiene (OH) are known major risk factors of periodontitis. Nevertheless, the magnitude of their effects has not yet been the subject of a meta‐analysis.Material and methodsThe Medline and Scopus databases were searched up to May 2016. Observational studies were eligible if they assessed associations between OH and periodontitis in adult subjects. A multivariate random‐effects meta‐analysis was used to pool the effects of fair/poor OH versus good OH on periodontitis across studies. The associations between oral care habits and periodontitis were also assessed.ResultsA total of 50 studies were eligible; 15 were used for pooling the effect of fair OH versus good OH and poor OH versus good OH on periodontitis, with pooled odds ratios (ORs) of 2.04 [95% confidence interval (CI): 1.65–2.53] and 5.01 (95% CI: 3.40–7.39), respectively. Eleven studies examined oral care habits measured according to toothbrushing regularity and dental visit frequency; pooled ORs of 0.66 (95% CI: 0.47–0.94) and 0.68 (95% CI: 0.47–0.98) were obtained, respectively.ConclusionsFair to poor OH increases the risk of periodontitis by two‐ to five‐fold. This risk can be reduced by regular toothbrushing and dental visits.

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Multi-omics study of key genes, metabolites, and pathways of periodontitis

Jun,

Yuanyuan,

Zhiqiang

et al. 2023

Archives of Oral Biology

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Polymorphic Regions in Fc Gamma Receptor and Tumor Necrosis Factor‐α Genes and Susceptibility to Chronic Periodontitis in a Cohort From South India

Abstract: Study results suggest the variant form of the SNP in FCGR2A 131His/Arg, FCGR2B 232Ile/Thr, TNFA -1031T/C, and TNFA -863C/A are not associated with CP susceptibility in the selected cohort from South India.

Cited by 10 publications

References 45 publications

FCGR Genetic Variation in Two Populations From Ecuador Highlands—Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene

FCGR Genetic Variation in Two Populations From Ecuador Highlands—Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene

The association between oral hygiene and periodontitis: a systematic review and meta-analysis

Multi-omics study of key genes, metabolites, and pathways of periodontitis

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