Polymorphism and desolvation of flupirtine maleate

Solid State Interconversion Between Anhydrous Norfloxacin and Its Hydrates

“…Thermal dehydration is the most common way to prepare anhydrous materials in the pharmaceutical industry. There are many publications reported the polymorphic transformation or occurrence of desolvation upon thermal treatment 27–30. In this study, a mild temperature of 60°C was selected to minimize potential chemical degradation associated with higher temperatures.…”

Furosemide Solvates: Can They Serve As Precursors to Different Polymorphs of Furosemide?

“…This method is a variant of a more general method of using various precursors to modify the properties of solid materials obtained in the course of solid-state reactions. − In some cases, decomposition of different precursors can give different polymorphs. This is widely used for a long time to obtain different polymorphs of inorganic compounds, for example of oxides applied as catalysts. , In the last years the same technique was used to produce different polymorphs of drugs, some of which cannot be easily obtained by direct crystallization from solutions. ,− Recently it was found that 2,4,6-triethyl-1,3,5-tris(phenoxymethyl)-benzene can form 10 different solvates which lead to the formation of 3 different polymorphs on desolvation . At the same time, three solvates having common dimeric or catemeric hydrogen bonded motifs and one hydrate with completely different molecular interactions of aripiprazole invariantly give the same polymorph of pure drug; three different isostructural solvates of tetroxoprim also give the same polymorph on desolvation whereas desolvation of another one results in two different polymorphs .…”

Comparison between dehydration and desolvation kinetics of fluconazole monohydrate and fluconazole ethylacetate solvate using three different methods

“…A change in the degree of solvation or hydration is one of the important transformation processes that may occur to the solid pharmaceuticals 10–12. Solvates or hydrates might affect the thermodynamic, kinetic, and mechanical properties of pharmaceutical compounds.…”