Polymorphism for Y-Linked Suppressors of sex-ratio in Two Natural Populations of Drosophila mediopunctata

Carvalho, Antonio Bernardo; Vaz, Suzana Casaccia; Klaczko, Louis Bernard

doi:10.1093/genetics/146.3.891

Cited by 74 publications

(17 citation statements)

References 25 publications

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“…Most important among these, for our purposes, are molecular genetic arms races, as sex chromosome drive favors the evolution of resistant alleles at the target ; suppressors at unlinked loci; and counter-resistance and/or suppressor-evasion at drive and linked enhancer loci. Sex chromosomes are thus subject to recurrent cycles of drive, resistance, suppression, counter-suppression, and so on ( Carvalho et al, 1997 ; Hall, 2004 ), resulting in the potential accumulation of multiple, divergent, species-specific “cryptic drive” systems— drive loci that persist but in a silenced state.…”

Section: Sex Chromosomes and Hybrid Sterilitymentioning

confidence: 99%

Hybrid Sterility, Genetic Conflict and Complex Speciation: Lessons From the Drosophila simulans Clade Species

Presgraves

Meiklejohn

2021

Front. Genet.

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The three fruitfly species of the Drosophila simulans clade— D. simulans, D. mauritiana, and D. sechellia— have served as important models in speciation genetics for over 40 years. These species are reproductively isolated by geography, ecology, sexual signals, postmating-prezygotic interactions, and postzygotic genetic incompatibilities. All pairwise crosses between these species conform to Haldane’s rule, producing fertile F1 hybrid females and sterile F1 hybrid males. The close phylogenetic proximity of the D. simulans clade species to the model organism, D. melanogaster, has empowered genetic analyses of their species differences, including reproductive incompatibilities. But perhaps no phenotype has been subject to more continuous and intensive genetic scrutiny than hybrid male sterility. Here we review the history, progress, and current state of our understanding of hybrid male sterility among the D. simulans clade species. Our aim is to integrate the available information from experimental and population genetics analyses bearing on the causes and consequences of hybrid male sterility. We highlight numerous conclusions that have emerged as well as issues that remain unresolved. We focus on the special role of sex chromosomes, the fine-scale genetic architecture of hybrid male sterility, and the history of gene flow between species. The biggest surprises to emerge from this work are that (i) genetic conflicts may be an important general force in the evolution of hybrid incompatibility, (ii) hybrid male sterility is polygenic with contributions of complex epistasis, and (iii) speciation, even among these geographically allopatric taxa, has involved the interplay of gene flow, negative selection, and positive selection. These three conclusions are marked departures from the classical views of speciation that emerged from the modern evolutionary synthesis.

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Section: Sex Chromosomes and Hybrid Sterilitymentioning

confidence: 99%

Hybrid Sterility, Genetic Conflict and Complex Speciation: Lessons From the Drosophila simulans Clade Species

Presgraves

Meiklejohn

2021

Front. Genet.

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“…Consistent with ERQ dynamics, there is evidence of recent selective sweeps at both loci [54], occurring more recently in both cases than the origin of the genes themselves, implying they are not in the first phase of an arms race, but an escalation. FRQ behaviour has not yet been observed in nature for selfish genetic elements, but is predicted to occur both for meiotic drive [55,56] and cytoplasmic male sterility (CMS) [57]. In CMS, certain mitochondrial genotypes prevent pollen production in hermaphrodite plants.…”

Section: Microevolution Of Intraspecific Conflictsmentioning

confidence: 99%

Running with the Red Queen: the role of biotic conflicts in evolution

et al. 2014

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What are the causes of natural selection? Over 40 years ago, Van Valen proposed the Red Queen hypothesis, which emphasized the primacy of biotic conflict over abiotic forces in driving selection. Species must continually evolve to survive in the face of their evolving enemies, yet on average their fitness remains unchanged. We define three modes of Red Queen coevolution to unify both fluctuating and directional selection within the Red Queen framework. Empirical evidence from natural interspecific antagonisms provides support for each of these modes of coevolution and suggests that they often operate simultaneously. We argue that understanding the evolutionary forces associated with interspecific interactions requires incorporation of a community framework, in which new interactions occur frequently. During their early phases, these newly established interactions are likely to drive fast evolution of both parties. We further argue that a more complete synthesis of Red Queen forces requires incorporation of the evolutionary conflicts within species that arise from sexual reproduction. Reciprocally, taking the Red Queen's perspective advances our understanding of the evolution of these intraspecific conflicts.

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“…A reduction in fertility is a common by-product of meiotic drive, and thus accelerated evolution at drive loci may disproportionately impact spermatogenesis genes, inadvertently increasing the chance of hybrid-sterility-causing interactions. The arms race between the evolution of drivers and suppressors is thought to cycle, each triggering evolution in the other (Carvalho et al 1997;Hall 2004). Because distorters may be evolving repeatedly on the X chromosome, this cycle model reinforces the idea that rapid evolution on the sex chromosomes could greatly increase divergence between species and may be a contributor to the large-X effect observed in genetic studies of hybrid sterility (Charlesworth et al 1987;Coyne & Orr 1989;Turelli & Orr 2000;Masly & Presgraves 2007;Tao et al 2007a,b).…”

Section: Forms Of Meiotic Drive and How They May (Or May Not) Contribute To Hybrid Sterilitymentioning

confidence: 99%

The role of meiotic drive in hybrid male sterility

McDermott

Noor

2010

Phil. Trans. R. Soc. B

114

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Meiotic drive causes the distortion of allelic segregation away from Mendelian expected ratios, often also reducing fecundity and favouring the evolution of drive suppressors. If different species evolve distinct drive-suppressor systems, then hybrid progeny may be sterile as a result of negative interactions of these systems' components. Although the hypothesis that meiotic drive may contribute to hybrid sterility, and thus species formation, fell out of favour early in the 1990s, recent results showing an association between drive and sterility have resurrected this previously controversial idea. Here, we review the different forms of meiotic drive and their possible roles in speciation. We discuss the recent empirical evidence for a link between drive and hybrid male sterility, also suggesting a possible mechanistic explanation for this link in the context of chromatin remodelling. Finally, we revisit the population genetics of drive that allow it to contribute to speciation.

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Polymorphism for Y-Linked Suppressors of sex-ratio in Two Natural Populations of Drosophila mediopunctata

Cited by 74 publications

References 25 publications

Hybrid Sterility, Genetic Conflict and Complex Speciation: Lessons From the Drosophila simulans Clade Species

Hybrid Sterility, Genetic Conflict and Complex Speciation: Lessons From the Drosophila simulans Clade Species

Running with the Red Queen: the role of biotic conflicts in evolution

The role of meiotic drive in hybrid male sterility

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