Polymorphism in <i>dopamine receptor D4</i> gene is associated with pigeon racing performance

Proskura, Witold Stanisław; Kustosz, Jakub; Dybus, Andrzej; Lanckriet, Ruben

doi:10.1111/age.12328

Cited by 19 publications

(25 citation statements)

References 6 publications

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“…Nowadays, numerous pigeon breeds are known, and some are used for either meat production, such as ornamental birds, or for pigeon sports (carrier pigeons) [ 3 ]. The carrier pigeons are used extensively for racing, and various studies have explored the influence of genetics and dietary parameters as well as infections on race performance [ 4 , 5 , 6 , 7 ]. The races have a very high physical burden on racing pigeons as they are held every week for 4 consecutive months with racing distancing ranging from 100 to 1000 km [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study Investigating the Dynamics of Pigeon Circovirus Recombination in Domesticated Pigeons Housed in a Single Loft

Khalifeh

Kraberger

Dziewulska

et al. 2021

Viruses

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Pigeon circovirus (PiCV) infects pigeon populations worldwide and has been associated with immunosuppression in younger pigeons. Recombination is a common mechanism of evolution that has previously been shown in various members of the Circoviridae family, including PiCV. In this study, three groups of pigeons acquired from separate lofts were screened for PiCV, and their genome sequence was determined. Following this, they were housed in a single loft for 22 days, during which blood and cloacal swab samples were taken. From these blood and cloacal swabs, PiCV genomes were determined with the aim to study the spread and recombination dynamics of PiCV in the birds. Genome sequences of PiCV were determined from seven pigeons (seven tested PiCV positive) before they were housed together in a loft (n = 58 sequences) and thereafter from the ten pigeons from blood and cloacal swabs (n = 120). These 178 PiCV genome sequences represent seven genotypes (98% pairwise identity genotype demarcation), and they share >88% genome-wide pairwise identity. Recombination analysis revealed 13 recombination events, and a recombination hotspot spanning the 3′ prime region, the replication-associated protein (rep) gene and the intergenic region. A cold spot in the capsid protein-coding region of the genome was also identified. The majority of the recombinant regions were identified in the rep coding region. This study provides insights into the evolutionary dynamics of PiCV in pigeons kept under closed rearing systems.

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Section: Introductionmentioning

confidence: 99%

A Pilot Study Investigating the Dynamics of Pigeon Circovirus Recombination in Domesticated Pigeons Housed in a Single Loft

Khalifeh

Kraberger

Dziewulska

et al. 2021

Viruses

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“…We had surveyed 5-HTT exon1 and ATP6 among Japanese racing pigeons but we couldn’t find polymorphism within these two genes (data not shown). Future functional genomics and linkage analyses must include more candidate genes (e.g., dopamine receptor D4 [ 17 ] or LDHA coding exons [ 23 ]) and more racing pigeon populations to confirm the relationship between genetic variation and complex traits such as survivability. Nonetheless, the microsatellite locus reported here should prove useful for marker-assisted selection that can maximize the genetic quality of racing pigeons and will further our knowledge regarding the genetic underpinnings of survivability and navigation ability in wild migrating bird species.…”

Section: Discussionmentioning

confidence: 99%

“…Genetic markers have been used to predict racing performance in humans [ 13 ], horses [ 14 ], dogs [ 15 ], and pigeons [ 6 , 16 , 17 ]. These studies have indicated that lactate dehydrogenase isoform A, encoded by the lactate dehydrogenase A gene ( LDHA ), is critical to the aerobic/anaerobic metabolism of different tissues and thus to overall physiological performance.…”

Section: Introductionmentioning

confidence: 99%

LDHA gene is associated with pigeon survivability during racing competitions

et al. 2018

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Pigeon racing is a popular sport worldwide. Pigeons are under continuous selection to improve speed, spatial orientation, and endurance during long flights. However, numerous genetic and non-genetic factors affect survivability and homing ability, making such traits difficult for breeders to control. Polymorphisms in the lactate dehydrogenase A gene (LDHA) likely affects pigeon racing and homing abilities, due to its role in physical and mental performance. Additionally, the adenylate cyclase activating polypeptide 1 gene (ADCYAP1) has been associated with physiological and behavioral shifts that occur during avian migration. In this study, we examined the association between LDHA and ADCYAP1 genotypes with pigeon survivability during racing competitions. Survivability was evaluated through the estimated breeding value (EBV) of each individual’s total race distances during its athletic life. ADCYAP1 was not polymorphic among our samples, while LDHA genotypes were significantly associated with deviated EBV values of longer total race distance; individuals carrying the S+ genotype had higher EBV (i.e., greater survivability). Thus, the LDHA locus might be useful for marker-assisted selection, empowering breeders and trainers to maximize pigeon quality. Moreover, data obtained from breeding will also improve our understanding of the genetic mechanism underlying navigation and flight for wild migrating bird species.

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“…Each lobe is 50-60 mm long and forms either an H or a U shape, as shown in Figure 1.1 below. It averages 25-30 g in adults, women having heavier glands than men (PubMed Health, 2015).…”

Section: Anatomy Of the Thyroid Glandmentioning

confidence: 99%

Expressional Analysis of Vascular Endothelial Growth Factor A (VEGFA) in Patients with Thyroid Cancer

Azhar¹

2018

Preprint

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Carcinogenesis of cells in the tissues of the thyroid gland leads to formation of thyroid cancer. Development of thyroid cancer involves a multifactorial route that is associated with various risk factors, such as exposure to ionizing radiation in early life, genetic predisposition, iodine intake in diet, environmental carcinogens, and genetic instability etc. These different risk factors can lead to a variety of mutations within proto-oncogenes and activating them as oncogenes. VEGF-A is one such proto-oncogene that plays a key role in tumour angiogenesis. The purpose of this study was to explore the association of respective gene with thyroid cancer pathogenesis. To test the hypothesis that VEGF-A expression patterns has influence in thyroid cancer metastasis and sustenance, a population based case-control study was conducted in 77 thyroid tumour samples along with adjacent control tissue samples. Quantitative real time-PCR (qPCR) was used for mRNA expression variation in VEGF-A gene. Expression analysis showed that VEGF-A expression level was very highly significantly downregulated (p<0.001) in tissues of thyroid cancer compared to adjacent control tissues. Non-significant (p>0.05) increase of VEGF-A expression mRNA with age group, gender, and advanced stages of T, N, and M stages was also observed in thyroid cancer samples compared to the controls. However, when compared for the expression levels relative to the proliferation marker, Ki67, very highly significant upregulation in thyroid tumour samples was seen in the same study cohort. Based on these results we can conclude that VEGF-A under expression at transcriptional level may be playing a key role in progression and/or spread of thyroid cancer.

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Polymorphism in dopamine receptor D4 gene is associated with pigeon racing performance

Cited by 19 publications

References 6 publications

A Pilot Study Investigating the Dynamics of Pigeon Circovirus Recombination in Domesticated Pigeons Housed in a Single Loft

A Pilot Study Investigating the Dynamics of Pigeon Circovirus Recombination in Domesticated Pigeons Housed in a Single Loft

LDHA gene is associated with pigeon survivability during racing competitions

Expressional Analysis of Vascular Endothelial Growth Factor A (VEGFA) in Patients with Thyroid Cancer

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