Polymorphism of BTN and GHR genes
and its impact on bulls’ breeding value
for milk production traits

Komisarek, Jolanta; Dorynek, Z.

doi:10.22358/jafs/67762/2003

Cited by 8 publications

(6 citation statements)

References 22 publications

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“…The frequencies of the minor allele R and the rare genotype KR of the BTN1A1 polymorphism were 6.21 and 12.41%, respectively. The allele frequencies in our Czech Fleckvieh cows were close to the results observed by Komisarek and Dorynek (2003) in Holstein cattle (12%) and Sadr et al (2008) in the Najdi cattle population (14%). Zegeye et al (1999) did not reveal a relationship between K468R polymorphism and milk production in five grand-sire Holstein families.…”

Section: Resultssupporting

confidence: 90%

Effect of DGAT1, BTN1A1, OLR1, and STAT1 genes on milk production and reproduction traits in the Czech Fleckvieh breed

Rychtářová¹,

Sztankóová²,

Kyselová³

et al. 2014

Czech J. Anim. Sci.

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ABSTRACT:The impact of polymorphism of the diacylglycerol acyltransferase (DGAT1), butyrophilin (BTN1A1), oxidized low-density lipoprotein receptor (OLR1), and signal transducer and activator of transcription 1 (STAT1) genes on milk production and reproduction traits in 419 Czech Fleckvieh cows was examined using polymerase chain reaction and restriction fragment length polymorphism. The loci DGAT1 and BTN1A1 were observed simultaneously to affect milk production, estimated breeding value of milk production traits, as well as reproduction parameters. Significant differences were found also between genotypes of the STAT1 loci in relation to estimated breeding value of milk production traits. Similar findings in pure dairy breeds suggest that heterogeneous effects of the observed loci can be explained by different genetic backgrounds in various breed populations selected to achieve different commercial goals. Thus, it is necessary to determine variability and influence of a molecular marker in a specific population when considering its inclusion into a breeding programme.

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Section: Resultssupporting

confidence: 90%

Effect of DGAT1, BTN1A1, OLR1, and STAT1 genes on milk production and reproduction traits in the Czech Fleckvieh breed

Rychtářová¹,

Sztankóová²,

Kyselová³

et al. 2014

Czech J. Anim. Sci.

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“…These were in correspondence with earlier reported frequencies of BTN1A1 allele as 0.875 and 0.125 (Taylor et al 1996a), 0.85 and0.15 (Husaini et al 1999), 0.84 and 0.14 (Sadr et al 2008), 0.88 and0.12 (Komisarek andDorynek 2003), 0.87 and 0.13 , 0.69 and 0.31 (Muszyńska et al 2010) in different milch bovines. Highest frequency was observed for AA genotype and A allele whereas lowest frequency was found for BB genotype and B allele.…”

Section: Resultssupporting

confidence: 92%

“…Bovine butyrophilin gene consists of 8 exons and 7 introns and is located on the 23 rd chromosome (Ashwell et al 1996). BTN1A1 is possibly QTL candidate gene affecting milk yield and composition in dairy animals (Komisarek and Dorynek 2003). Franke et al (1981) suggested that butyrophilin is widely expressed during lactation and is specific to mammary tissue.…”

Section: Introduc Onmentioning

confidence: 99%

Allelic diversity of butyrophilin (BTN1A1) gene in Indian bovines

Kumar

Ratwan

Das

et al. 2018

Indones. J. Biotechnol.

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Indian milch bovines comprise 58.56% of the total livestock popula on (512.05 million) in the country and primarily include na ve and crossbred ca le (37.28%) and water buffaloes (21.28%). Milk and milk products are essen al food items in Indians' diet, especially in children and the elderly and senile. Milk fat is an important cons tuent of milk and has an economic value and its percentage in milk varies between species and breeds within species. Butyrophilin (BTN1A1) is a membrane protein that regulates the secre on of lipids and size of a fat globule in milk. The present study was conducted on 538 bovines from 11 breeds/popula ons adapted to different parts of India, with an aim to screen and determine the major allele of the BTN1A1 gene. The genotyping of samples was done using PCR-RFLP based tests. The results indicated that exon8 of the BTN1A1 gene was polymorphic in the Tharparkar, Sahiwal, Jhari, and Belahi popula ons of the na ve ca le, as well as the Holstein Friesian and Jersey crossbreeds. Meanwhile, exon 8 was monomorphic in the Murrah, Chilika, Gojri, Chha sgarhi, and Bargur popula ons of water buffalo. Allele A was iden fied as the major allele in Indian bovines. We conclude that varia ons in the BTN1A1 gene can serve as an excellent gene c marker in the selec on of ca le with higher milk fat, and can be applied when formula ng their breeding plans.

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“…T h e frequency of dominant allele K in different studies were0.88 by Komisarek and Dorynek (2003), 0.83 by Bhattacharya et al (2006), 0.86 by Sadr et al (2008), 0.88 by Rengarajan (2011), 0.89 by Vishwanath (2014) and 0.86 by Al-Waith (2019). Thus, the results of K allele dominance was in accordance with all aforementioned studies.…”

Section: High Resolution Melt Curve Analysismentioning

confidence: 90%

Association of Butyrophilin gene polymorphism (A465G) with milk production traits in Holstein Friesian crossbred cattle of Kerala

Hemanth¹,

Lali²,

Anilkumar³

et al. 2022

Journal of Veterinary and Animal Sciences

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The butyrophilin (BTN1A1) gene is found at a quantitative trait locus (QTL) in cattle for milk production traits. The effect of a single nucleotide polymorphism (SNP) A465G in exon 8, which causes a lysine to arginine transition, on milk production attributes in Holstein Friesian crossbred cattle from Kerala was investigated in this study (151 numbers). Using custom synthesised primers, a 90-bp fragment encompassing the polymorphic region was amplified from genomic DNA isolated.Genotyping was carried out by high resolution melt curve analysis (HRM) and two genotypes KK (0.25) and KL (0.75) were detected based on melting temperature and melt curve patterns.Sanger’s sequencing and sequence analysis of representative samples confirmed the genotypes.Chi-square test showed that the population was not distributed as per Hardy-Weinberg equilibrium(p≤0.05). The relationship between the A465G transition and milk production traits like 305 daymilk, fat, SNF yields, fat and SNF per cent was determined by general linear model-analysis of variance (GLM-ANOVA). In the model herd, season of calving, parity of animal (non-geneticfactors), and genotype were considered fixed variables and milk production traits as dependent variable. The study revealed significantly higher (p≤0.01) milk fat and SNF per cent for KK genotype(4.14±0.08 %; 7.86±0.06 %) than KL genotype (3.91±0.07 %; 7.73±0.05 %). The butyrophilin genepolymorphism (A465G) can be recommended as a marker for higher milk fat and SNF per cent infuture breeding programmes in crossbred cattle of Kerala.

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Polymorphism of BTN and GHR genes and its impact on bulls’ breeding value for milk production traits

Cited by 8 publications

References 22 publications

Effect of DGAT1, BTN1A1, OLR1, and STAT1 genes on milk production and reproduction traits in the Czech Fleckvieh breed

Effect of DGAT1, BTN1A1, OLR1, and STAT1 genes on milk production and reproduction traits in the Czech Fleckvieh breed

Allelic diversity of butyrophilin (BTN1A1) gene in Indian bovines

Association of Butyrophilin gene polymorphism (A465G) with milk production traits in Holstein Friesian crossbred cattle of Kerala

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