Effect of DGAT1, BTN1A1, OLR1, and STAT1 genes on milk production and reproduction traits in the Czech Fleckvieh breed

Rychtářová, Jana; Sztankóová, Z.; Kyselová, J; Zink, V.; Štípková, M.; Vacek, M; Štolc, L.

doi:10.17221/7228-cjas

Cited by 18 publications

(28 citation statements)

References 31 publications

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“…We report in this study that OLR1-C223A may affect AFC in the Holstein breed. On the contrary, Komisarek & Dorynek (2009) and Rychtarova et al (2014) found no significant association between this marker and any of the reproduction traits analysed The OLR1 gene influences glucose and lipid metabolisms because it encodes a vascular endothelial cell-surface receptor that binds and degrades the oxidised forms of low-density lipoproteins (Mehta & Li, 2002). Thus, the existence of a novel association between OLR1-C223A and reproduction parameters in cattle would not be surprising.…”

Section: Discussionmentioning

confidence: 96%

“…This gene is located in the interval of 106 cM to 108 cM of bovine chromosome 5, where the functional and positional candidate genes associated with fatty acid contents in milk have been mapped (Khatib et al, 2006). The signal transducer and activator of the transcription 1 (STAT1) gene encodes the cytoplasmic transcription factor (STAT1) that acts as a regulator in cytokine signalling pathways and cellular functions involving proliferation, differentiation and apoptosis (Rychtarova et al, 2014). STAT1 is located on chromosome 2 and is associated with improved milk yield and content (Khatib et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of candidate gene effects and environmental factors on reproductive performance of Holstein cows

Ardıçlı¹,

Şamlı²,

Soyudal³

et al. 2019

SA J. An. Sci.

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This study investigated the impact of nine polymorphisms located in the CSN2, CSN3, CSN1S1, CSN1S2, OLR1, LALBA, STAT1, DGAT1 and LGB genes, and environmental factors including calving year, season and parity on reproductive traits. The analysis was conducted on 165 Holstein-Friesian cows. Genotypes were identified using PCR-RFLP. The data of reproductive traits for four lactations were evaluated. Statistical analysis was carried out using least squares of the GLM procedures. Results indicated that CSN2 had significant effects on days before first insemination and first insemination to pregnancy interval. The SNP at the CSN3 was significantly associated with gestation length. A novel effect of OLR1-C223A on age at first calving was observed in the present study. Moreover, DGAT1 and LGB markers were significantly associated with calving interval and days before first insemination, respectively. In addition, significant environmental effects were as follows: calving year with days before first oestrus, days open, and first insemination to pregnancy interval; season with days open, first insemination to pregnancy interval, and calving interval; parity with days before first oestrus and days open. The present results and novel associations may therefore be useful and indicative for future studies on a genetic basis of cattle reproduction traits.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Evaluation of candidate gene effects and environmental factors on reproductive performance of Holstein cows

Ardıçlı¹,

Şamlı²,

Soyudal³

et al. 2019

SA J. An. Sci.

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“…Our results are coincident with previous studies. Jointly with other candidate loci (Rychtarova et al 2014), FGF2 SNP11646 continues to be of interest for future cattle breeding studies.…”

Section: Resultsmentioning

confidence: 99%

Effect of the FGF2 SNP11646 on milk production and fertility traits of Holstein cattle

Brzáková¹,

Hosnedlová²,

Svitáková³

et al. 2016

CZECH J ANIM SCI

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Th e objective of this study was to estimate the eff ect of a single-nucleotide polymorphism (SNP11646) in the FGF2 (Fibroblast Growth Factor 2) gene on the deregressed proof of breeding values (DRP) of Holstein sires (n = 149) for milk traits (milk yield, fat yield and percentage, and protein yield and percentage) and fertility (relative breeding value for own fertility -conception rate of heifers, cows, all females inseminated by the sperm of the sire; relative breeding value for conception rate of daughters -heifers, cows, all females). Th e diff erences between genotypes for milk performance were not signifi cant. Th e lowest DRP for milk performance were found for AA sires. For fertility, sires with this genotype had the best values both for the maternal genetic eff ect (conception rate of the daughters) and for the direct genetic eff ect (fertility of the sire). For conception rate of the daughters, in some cases, the diff erences reached the threshold of signifi cance. Th us, the results indicate coincidently with other studies the potential opposing eff ects on milk performance and fertility. FGF2 SNP11646 is still of interest for future cattle breeding studies.

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“…In that study, the frequencies of the CC, CT, and TT genotypes were as 71.60%, 26.75%, and 2.15%, respectively. Furthermore, significant differences in milk protein contents were observed among the all genotypes [10] . In a previous study performed for the STAT1 gene, the effects of CC and CT genotypes calculated as a deviation from TT genotype had a significant impact of increasing milk yield as well as milk protein and fat yields in North American Holstein cows [11] .…”

Section: Introductionmentioning

confidence: 93%

Türkiye’de Holstein, Jersey ve Yerli Sığır Irklarında STAT1 ve STAT5A Genlerinin Genetik Polimorfizmi

Cobanoglu¹,

Kul²,

Abacı³

et al. 2019

Kafkas Univ Vet Fak Derg

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This study aimed to determine genetic polymorphism in STAT1 and STAT5A genes for dairy cattle and some native cattle breeds in Turkey. 283 Jersey and a total of 472 Holstein cows from two different herds and 93 Grey Steppe, 85 Anatolian Black Cattle, and 66 East Anatolian Red cattle were used in this research. Generally, C allele gene frequency was higher than T allele for STAT1 in all breeds whereas C allele gene frequency was detected higher than G allele for STAT5A in Jersey and East Anatolian Red. On the other hand, G allele gene frequency was higher than C allele in Holstein, Grey Steppe, and Anatolian Black Cattle breeds. The expected deviations from the Hardy-Weinberg Equilibrium were significant only for Jersey breeds for STAT1 gene. Meanwhile, the expected deviation from equilibrium was also significantly different for Holstein in Black Sea Region (BSR), Anatolian Black Cattle and Grey Steppe for the STAT5A gene. FIS values were determined to STAT1 gene as negative for all breeds except for Holstein in Marmara Region (MR). Similarly, this value was determined to STAT5A gene as positive for all breeds except for Holstein in BSR. The genetic distances for two loci were calculated between 0.0029 and 0.1599 among all populations. Depending on the cluster analysis, Holstein in BSR and MR, Anatolian Black Cattle, East Anatolian Red were closely clustered to each other, while Grey Steppe and Jersey were located in completely different clusters. As a conclusion, based on the detected genetic diversity in STAT1 and STAT5A genes, it is possible to make a genetic improvement among bovine breeds raised in Turkey.

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Effect of DGAT1, BTN1A1, OLR1, and STAT1 genes on milk production and reproduction traits in the Czech Fleckvieh breed

Cited by 18 publications

References 31 publications

Evaluation of candidate gene effects and environmental factors on reproductive performance of Holstein cows

Evaluation of candidate gene effects and environmental factors on reproductive performance of Holstein cows

Effect of the FGF2 SNP11646 on milk production and fertility traits of Holstein cattle

Türkiye’de Holstein, Jersey ve Yerli Sığır Irklarında STAT1 ve STAT5A Genlerinin Genetik Polimorfizmi

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