2015
DOI: 10.14499/indonesianjpharm26iss1pp11
|View full text |Cite
|
Sign up to set email alerts
|

Polymorphism of Cytochrome P450 2a6 (Cyp2a6*1 and Cyp2a6*4) Among Javanese Indonesian Smoker and Non Smoker

Abstract: Cytochrome P450 2A6 (CYP2A6) is the principal enzyme involved in the metabolic activation of tobacco-specific nitrosamines to their ultimate carcinogenic forms and metabolism of nicotine. The present study was developed to investigate the genetic polymorphism of CYP2A6 in Javanese Indonesian subjects carrying the CYP2A6*1 allele and the CYP2A6*4. The whole gene deletion of CYP2A6 (CYP2A6*4) may inhibit smokers from giving up smoking, but appears to function as a protective factor against some cancer. However, … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

5
5
0

Year Published

2019
2019
2022
2022

Publication Types

Select...
7

Relationship

4
3

Authors

Journals

citations
Cited by 10 publications
(10 citation statements)
references
References 34 publications
5
5
0
Order By: Relevance
“…They are CYP2A6*1/*1 (normal metabolizer) 6.45%; CYP2A6*1/*4 (slow metabolizer) 87.10%; and CYP2A6*4/*4 (poor metabolizer) 6.45%. This result was in line with the previous study, which is among the Javanese Indonesia population, the percentage of slow metabolizer was high (Patramurti and Fenty, 2017;Patramurti et al, 2015). The presence of the CYP2A6*4 allele significantly affects cigarette dependence.…”
Section: Resultssupporting
confidence: 91%
“…They are CYP2A6*1/*1 (normal metabolizer) 6.45%; CYP2A6*1/*4 (slow metabolizer) 87.10%; and CYP2A6*4/*4 (poor metabolizer) 6.45%. This result was in line with the previous study, which is among the Javanese Indonesia population, the percentage of slow metabolizer was high (Patramurti and Fenty, 2017;Patramurti et al, 2015). The presence of the CYP2A6*4 allele significantly affects cigarette dependence.…”
Section: Resultssupporting
confidence: 91%
“…As described in Table 2, it appears that the CYP2A6*4 alleles frequency among the participants is 42.39%. All of the subjects who participated in this study are Javanese, so this result was consistent with our previous studies that were resulted in the allele frequency of the CYP2A6*4 among Javanese smokers was high (Patramurti et al, 2015). Tanner and Tyndale (2017) have also noticed that among Asian populations, the allele frequencies of an inactive CYP2A6 gene were higher compared to Caucasians.…”
Section: Results and Discusionsupporting
confidence: 91%
“…This polymorphism of CYP2D6 among Javanese had similarity with the polymorphism of CYP2A6 among the same genetic ethnic of Javanese [23]. Genetically, CYP2A6*4 was found higher compared to the occurrence of CYP2A6*1 among smoking and non-smoking subject.…”
Section: Resultssupporting
confidence: 55%