Polymorphism of genes of hemostasis system, endothelial dysfunction and regulation of blood pressure in pregnant woman with preeclampsia and fetal growth retardation

Loskutova, T. O.

doi:10.14739/2310-1237.2018.1.127709

Cited by 4 publications

(3 citation statements)

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“…Taking into account, known from the literature [7,9,13], the relationship of the severity of placental insufficiency and fetal growth retardation syndrome (FGR) with the state of rheological and aggregation properties of blood, we studied hemocoagulation parameters in pregnant women of the prognosis group in order to identify prognostic signs of the risk of developing maladaptive disorders in the FPC. The dynamics of changes in hemocoagulation parameters in the I and early II trimester, relative to the CG, is shown in Fig.…”

Section: Research Results and Their Discussionmentioning

confidence: 99%

“…T he main characteristics of the GOS are [1,2]: multi etiology; prolonged preclinical stage; frequent fetal involvement; adaptive nature of clinical manifestations. The development of syndromes is the result of complex interactions between maternal and fetal genomes and the environment [5][6][7][8][9]. The following conditions are classified as GOS: preterm birth; premature rupture of membranes; preeclampsia; fetal growth retardation; macrosomia; missed abortion; stillbirth; spontaneous abortion; placental abruption [10][11][12][13][14][15][16][17][18][19][20].…”

Section: г і н е к о л о г і яmentioning

confidence: 99%

“…The search for effective methods of predicting GOS is ongoing in order to correct the disorders early and reduce the negative consequences for the mother and fetus. Despite the sufficient study of the problem, there is still no single point of view on the peculiarities of the pathogenesis of disorders of the functional state of the fetoplacental complex, which are the basis for the development of GOS, no unified methodological approaches to early diagnosis have been developed, and there are no standards for the examination and treatment of pregnant women with identified disorders [5][6][7][8][9]. Therefore, the development of an effective methodology for predicting the development of «great obstetrical syndromes» becomes relevant and timely.…”

Section: г і н е к о л о г і яmentioning

confidence: 99%

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Basic principles and structure of risk assessment of Great obstetrical syndromes

Lemish

2022

RHW

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The objective: to develop a method for predicting the individual risk for great obstetric syndromes (GOS).Materials and methods. An analysis of the somatic, reproductive, and obstetric anamnesis was conducted in 572 pregnant women with clinical manifestations of GOS, in 81 of them (prediction group) signs of placental dysfunction were detected based on clinical, functional, laboratory, and ultrasound data. Control group (CG) – 50 practically healthy pregnant women with a favorable reproductive history and an uncomplicated course of this pregnancy.Functional, biophysical, hormonal, immunological and hemocoagulation indicators were calculated to determine the informative (prognostic) significance. Quantitative signs were divided into diagnostic intervals, and qualitative signs were assigned a code. The following indicators were included in the standard protocol: age, data on somatic and gynecological history, data on the pregnancy course, results of functional and laboratory examinations. Statistical processing of research results was carried out using standard Microsoft Excel 5.0 and Statistica 6.0 programs. Results. In the I trimester of pregnancy the concentration of placental lactogen (PL) in the prediction group was 29.4 % lower than the CG indicator, estradiol (E2) amount – by 27.4 %, estriol (E3) – by 28.6 %, progesterone (PG) – by 34.4%, human chorionic gonadotropin (hCG) – by 28.3 % lower, and cortisol (CR) – by 36.1 % higher. At the beginning of the II trimester of pregnancy in the prediction group the level of PL was already reduced by 33.8 %, E2 – by 26.2 %, E3 – by 32.3 %, PG – by 37.4 %, hCG – by 30.6 %, and CR – increased by 43.6 % compared to CG.The indicators of placenta hormonal activity in the early stages of pregnancy and at the beginning of the II trimester can be prognostic signs of further disruption of the adaptive compensatory and adaptive reactions of the fetal placental complex (FPC) in the II and III trimesters of pregnancy. Among a wide range of hemostasiological indicators in the I trimester of pregnancy in the prediction group the most informative were: activated partial thromboplastin time (-23 %) and activated recalcification time (+16.2 %), the changes of which remained at the beginning of the II trimester (-40% and - 11.7% respectively). During the evaluation of thromboelastogram data, the value of “r+k” was fixed by 33.3 % lower in the I trimester and by 36 % – at the beginning of the II trimester of pregnancy. As a result of the analysis the indicators with a high information value (more than 3.0 c.u.) were selected for quantitative assessment of the degree of individual risk for the development of maladaptive disorders in the FPC. The clinical trial of the scoring method of prediction proved its high sensitivity (91.8 %) and specificity (85.6 %). Conclusions. A multi-faceted analysis of anamnestic data, features of the pregnancy course, basic clinical, laboratory and functional indicators in women with clinical manifestations of GOS made possible to develop an effective methodology for predicting the risk for GOS development with high levels of sensitivity and specificity.

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Section: Research Results and Their Discussionmentioning

confidence: 99%

Section: г і н е к о л о г і яmentioning

confidence: 99%

Section: г і н е к о л о г і яmentioning

confidence: 99%

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Basic principles and structure of risk assessment of Great obstetrical syndromes

Lemish

2022

RHW

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Correction of placental dysfunction in the first trimester of pregnancy as a method of preventing fetal growth retardation

Беленичев

2023

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Objective: to study the effectiveness of complex therapy of placental dysfunction (PD) as a method of prevention of fetal growth retardation syndrome in pregnant women with miscarriage in the 1st trimester of pregnancy.Materials and methods. 100 pregnant women with verified PD on the background of miscarriage in the first trimester of pregnancy took part in the study.Verification criteria for PD were: a decrease in the volume of the chorion and its vascularization index by more than 15%, an increase of the resistance index in the uterine and spiral arteries during dopplerometric examination at the end of the first trimester of pregnancy.The patients were divided into groups: group I (main) – 36 pregnant women with PD who received complex treatment, group II (comparative) – 32 pregnant women with PD who were prescribed only hormonal support, III group (control) – 32 patients with the physiological course of the first trimester of pregnancy. Complex therapy in the group I included hormonal agents, venotonic drug Normoven, the drug Magnicum, and the drug Artihol.Clinical data, ultrasound fetometry, dopplerometric study of utero-fetal blood flow were used to assess the effectiveness of treatment.Results. Already in the 22–24th week of gestation there was no significant difference in the resistance index in the spiral and uterine arteries between the main and control groups (p > 0.05). Ultrasound fetometry at 32–34 weeks of gestation showed that in the first group there were 8.3% (3) fetuses small for gestational age, 15.6% (5) in the second group and 3.1% (1) in the control. The average body weight of newborns in the main group and in the comparison group differed significantly and was 2810 ± 267 and 2610 ± 175 g respectively (р < 0.05) and 3295 ± 295 g in the control group.Conclusions. Complex, pathogenetically justified, long-term treatment of PD from the early stages of pregnancy makes it possible to avoid progression of compensated and development of subcompensated stages of placental disorders. Complex therapy of PD, which includes micronized progesterone, Normoven, Artichol and Magnicum, Complex PD therapy, which includes micronized progesterone, Normoven, Artihol and Magnicum, normalizes blood flow in the mother-placenta-fetus system, normal growth and fetus development and is an effective way of preventing fetal growth retardation.

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Gene polymorphism of blood coagulation factors and endothelial dysfunction in early and late preeclampsia.

Loskutova¹,

Demchenko²

2020

Medicni Perspektivi (Medical Perspectives)

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Polymorphism of genes of hemostasis system, endothelial dysfunction and regulation of blood pressure in pregnant woman with preeclampsia and fetal growth retardation

Cited by 4 publications

References 3 publications

Basic principles and structure of risk assessment of Great obstetrical syndromes

Basic principles and structure of risk assessment of Great obstetrical syndromes

Correction of placental dysfunction in the first trimester of pregnancy as a method of preventing fetal growth retardation

Gene polymorphism of blood coagulation factors and endothelial dysfunction in early and late preeclampsia.

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