Polymorphism of Growth Hormone and Prolactin Genes in Connection With Milk Quality Determinants in Cattle of the Yaroslavskaya Breed

Lazebnaya, I. V.; Лазебный, О. Е.; Maximenko, V.F.; Sulimova, G.E.

doi:10.15389/agrobiology.2012.2.39eng

Cited by 3 publications

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“…Knowing the nucleotide sequence and localization of a specific marker, it is possible to identify polymorphic regions, which subsequently makes it possible to establish a connection between the polymorphic variant and one or another economically useful trait, intrauterine pathology, neonatal disease, etc. [7][8][9][10][11]. One of the genes that control the quality of milk is the gene for kappa-casein, since the amount of immunoglobulins depends on its density.…”

Section: Introductionmentioning

confidence: 99%

Influence of polymorphism of the kappa-casein gene of cows on the development of calves in the early postnatal period

et al. 2021

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The authors found that the density of colostrum in cows with a homozygous genotype for the B allele of the kappa-casein gene was higher compared to the homozygous genotype for the A allele and had a greater amount of immunoglobulins by 29.5 mg/l, respectively. The formation of high colostral immunity in calves obtained from cows of mothers of genotypes AB and BB prevented the occurrence of diseases of the gastrointestinal tract, and in calves obtained from mothers of genotype AA genotype kappa-casein with a reduced amount of immunoglobulins in colostrum, it led to the development of diarrhea in 12% of newborn calves. The dynamics of the live weight of calves obtained from cows of mothers with the AA genotype of the kappa-casein gene, during the first 30 days of life, was 6.34 and 4.78 kg lower than in young cows with the BB and AB genotypes of the kappa-casein gene. At the age of one month, the leukocyte content in calves obtained from cows from mothers with a homozygous genotype for allele A of the kappa-casein gene was less by 10.8 and 16.2%, and hemoglobin by 10.5 and 10.7%.

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Section: Introductionmentioning

confidence: 99%

Influence of polymorphism of the kappa-casein gene of cows on the development of calves in the early postnatal period

et al. 2021

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“…Restriction polymorphism for AluI sites in the fifth exon of the gene is associated with a C to G transver sion, leading to the replacement of a leucine amino acid by valine in the protein product (Leu to Val at position 127). A connection has been reported between different polymorphic variants of the bGH gene and economically useful cattle traits such as growth, maturation, and milk production (milk yield, fat, and protein in milk) [10][11][12][13][14]. In particular, it has been shown that the growth hormone has an effect on accumulation of fat in the muscle tissue.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of bGH, RORC, and DGAT1 genes in Russian beef cattle breeds

et al. 2014

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We examined the allelic and genotypic polymorphisms of genes of the retinoic acid receptor related orphan receptor C (RORC), diacylglycerol acyltransferase 1 (DGAT1), and growth hormone (bGH) in Russian beef cattle breeds in two populations of Kazakh white headed cattle (of Kazakh and Russian selec tion) and the Kalmyk cattle breed, as well as in the Mongolian hogorogo breed, which is related to Kalmyk breed. The studied genes are associated with parameters of meat quality: marbleness (bGH and RORC) and tenderness (DGAT1). They are also associated with an increase in carcass weight (bGH). We found that Rus sian and Kazakh populations of the Kazakh white headed breed were characterized by a high content of the AA genotype of RORC (0.713 and 0.608, respectively) and of the AA genotype of DGAT1 (0.913 and 0.975), both of which are preferable for meat quality. The total frequencies for the combined genotypes for the bGH and RORC genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white headed cattle (GG/AA and GC/AA-68.8 and 57% in the Russian and Kazakh populations, respec tively) exceeded the frequencies in the two other studied breeds by two times. Overall, the obtained results point to the high genetic potential of both populations of Kazakh white headed cattle breeds in beef produc tion. Results of this study can be used to improve the selection of meat traits in industrial livestock.

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“…Unfortunately, it is not possible to compare our results with those other researchers due to their limitations. Most scientific works are devoted to studies of the complex genotypes influence on milk productivity and milk quality in dairy breeds (Belaya et al, 2012b;Plivachuk and Dyman, 2016;Tyulkin, 2018;Safina et al, 2018;Mauriae et al, 2017;Lazebnaya et al, 2012).…”

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Marking of Meat Productivity Features in Pairs of bGH, bGHR and bIGF-1 Polymorphic Genes in Aberdeen-Angus Cattle

Dushayeva¹,

Наметов²,

Бейшова³

et al. 2021

OnLine Journal of Biological Sciences

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The purpose of the study is to identify paired combinations associated with meat productivity in Aberdeen-Angus cattle for the genes of the somatotropin cascade (growth hormone bGH, growth hormone receptor bGHR, insulin-like growth factor-1 bIGF-1). The determination of animal genotypes was carried out by PCR-RFLP. Results of statistical processing was carried out using the software capabilities of "Microsoft Excel 2010" and "Statistica 6.0". Paired combinations study of bGH, bGHR and bIGF-1 somatotropin cascade revealed marking diplotype polymorphic genes associated with signs of meat productivity and allowing for a comprehensive assessment of the Aberdeen-Angus cattle genetic potential in the postnatal development early stages. Thus, the animals' live weight with the bGH-AluI VV -bIGF-1-SnaBI BB diplotype at the age of 24 months exceeds the Aberdeen-Angus breed live weight standard by 45 kg (12%) and the total sample -by 12.52 kg (3%). The bGH-AluI LL -bIGF-1-SnaBI AA diplotype score is 2.93% higher than the total sample. The mass index average value of animals with the bGH-AluI LV -bGHR-SspI FY diplotype at 18 months is 3.98% lower than the total sample. In animals with the bGHR-SspI FF -bIGF-1-SnaBI BB diplotype at the age of 24 months, the churn index value is lower than the total sample by 3.74%. Thus, the diplotypes bGH-AluI VV -bIGF-1-SnaBI BB and bGH-AluI LL -bIGF-1-SnaBI AA can be considered genetic markers of increased meat productivity and the diplotypes bGH-AluI LV -bGHR-SspI FY and bGHR-SspI FF -bIGF-1-SnaBI BB -reduced meat productivity. The animals' selection with diplotypes that increase meat productivity will reduce the investment period and increase the agricultural production profitability. For breeding activities, it is recommended to maintain the animals' number with the diplotypes bGH-AluI VV -bIGF-1-SnaBI BB and bGH-AluI LL -bIGF-1-SnaBI AA .

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Polymorphism of Growth Hormone and Prolactin Genes in Connection With Milk Quality Determinants in Cattle of the Yaroslavskaya Breed

Cited by 3 publications

References 0 publications

Influence of polymorphism of the kappa-casein gene of cows on the development of calves in the early postnatal period

Influence of polymorphism of the kappa-casein gene of cows on the development of calves in the early postnatal period

Polymorphisms of bGH, RORC, and DGAT1 genes in Russian beef cattle breeds

Marking of Meat Productivity Features in Pairs of bGH, bGHR and bIGF-1 Polymorphic Genes in Aberdeen-Angus Cattle

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