Polymorphism of Human C6

Hobart, M. J.; Lachmann, P. J.

doi:10.1016/b978-0-08-018233-9.50107-0

Cited by 78 publications

(50 citation statements)

References 16 publications

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“…Genetic polymorphism of the sixth component of human complement (C6) was first detected by Hobart et al (1975). Subsequent investigations on C6 in several populations have shown a high degree of allelic variation particularly among Asian-Pacific populations (Kunstmann et aL, 1980;Olving et al, 1980;Ranford et al, 1982;Tokunaga et aL, 1983Tokunaga et aL, , 1984.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of complement C6 and C7 in two Chinese populations

et al. 1986

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SummaryGenetic polymorphisms of the complement components C6 and C7 in two Chinese populations (Beijing and Guangzhou) were investigated, using isoelectric focusing and immunoblotting technique. Three common and four rare allotypes of C6 were observed, and one of the rare allotypes was considered to be a new variant. Ten different patterns of C7 observed were classified into three homozygous and seven heterozygous phenotypes, indicating occurrence of four common and a new variant alleles. The new variants of C6 and C7 detected were designated as C6 B21 and C7 6, respectively. There was no statistically significant difference for C6 and C7 allele frequencies between the Beijing and the Guangzhou populations except for C7"4. The C7"4 frequency was shown to be significantly higher in Beijing than in Guangzhou. No significant positive association between C6 and C7 alleles was found.

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Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of complement C6 and C7 in two Chinese populations

et al. 1986

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“…Genetic polymorphism of the sixth component of human complement (C6) was first described by Hobart et aL (1975). The polymorphism has been shown to be controlled by codominant alleles at a single autosomal locus.…”

Section: Introductionmentioning

confidence: 99%

An immunoblotting technique for complement C6 typing: Three new variants

1984

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SummaryAn immunoblotting method for C6 typing was developed. After isoelectric focusing in thin-layer polyacrylamide gel, C6 proteins were transferred passively to nitrocellulose and then detected by a two-step enzyme immunoassay. A population sample of northeastern Japanese was investigated using this method. Three common and four rare allotypes were observed. The allele frequencies estimated from 495 blood donors were as follows: C6*A 0.423, C6*B 0.510, C6"B2 0.062, and rare alleles (91, Mll, B4, and B5) 0.005. Three variants, 91, Mll, and B5, were considered to be newly found. This method could be applicable to many other protein systems.

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“…Two common alleles, C6*A and C6*B, and several rare variants at a single autosomal locus have been described in Caucasians using prolonged agarose gel electrophoresis or polyacrylamide gel isoelectric focusing followed by hemolytic overlay (Hobart et al, 1975;Mauff et al, 1980). Whitehouse and Putt (1983) applied an immunoblotting procedure, involving electrophoretic protein transfer, in order to obtain C6 patterns after isoelectric focusing.…”

Section: Introductionmentioning

confidence: 99%

Human C7 polymorphism: Classification and association analysis with C6

et al. 1986

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SummaryPolymorphism of the seventh component of human complement (C7) was investigated in Japanese. Four common and one rare allotypes were observed with desialized samples. Besides three common alleles, C7"1, C7"2 and C7"4, the existence of the hypomorphic variant, C7"3, was confirmed in Japanese with a polymorphic frequency. The recently described C7"5 was found to correspond to C7"3 by comparing with reference samples. Moreover, a rare variant, tentatively named C7 7, was considered to be new. The population samples were also typed for C6. A rare variant, designated M92, was newly found. No significant associations between C6 and C7 alleles were found.

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Polymorphism of Human C6

Cited by 78 publications

References 16 publications

Genetic polymorphisms of complement C6 and C7 in two Chinese populations

Genetic polymorphisms of complement C6 and C7 in two Chinese populations

An immunoblotting technique for complement C6 typing: Three new variants

Human C7 polymorphism: Classification and association analysis with C6

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