Polymorphism of lipid exchange genes in some populations of South and East Siberia

Abstract

Lipid metabolism disorders underlie the pathogenesis of a number of diseases. Indigenous peoples of Siberia have a specific genetically determined type of metabolism supporting such lipid blood parameters that favor increased consumption (in comparison with Caucasians) of animal products. At the same time, indigenous Siberian ethnic groups are less susceptible to metabolic diseases. The objective of the presented study was to investigate the allele frequencies of lipid metabolism genes in indigenous populations of Siberia to identify the ethnic features of allele frequency distribution for polymorphic variants in genes CETP (G1264A, rs5882), LPL (C1791G, rs328) and FTO (C83401A, rs8050136) in the samples taken from Buryats, Teleuts and Russians of Eastern Siberia, and to compare them with data on world populations. Samples of the Eastern (N = 132) and Western (N = 278) Buryats, Teleuts (N = 120), Russians (N = 122) and persons of mixed Buryat-Russian origin (N = 56) were genotyped by real-time PCR using competitive TaqMan-probes. The obtained results have for the first time demonstrated that the CETP and FTO allele frequencies in the Buryat samples are intermediate between European and East Asian populations. Significantly lower incidence of the obesity-assossiated 83401A allele of the FTO gene has been shown in Buryats, compared with Russians, which is consistent with lower susceptibility of the indigenous ethnic groups to metabolic disorders. There have been no population differences in the distribution of LPL gene polymorphic variants associated with dyslipidemia, which means they probably do not contribute to the ethnic characteristics of the lipid profile. The intermediate frequencies of the CETP 1264G and FTO 83401A alleles found in the metis group demonstrate that the metabolic disorders associated with these variants can be rather expected in the descendants of mixed marriages than among Buryats. It has also been demonstrated that Teleuts differ by FTO 83401A allele frequency from some of the European groups and have the lowest detected frequency of the allele CETP 1264G associated with the favorable lipid blood parameters.

Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians

“…Thus, according to the frequency of occurrence of Alleles IL6-174G and IL6-572C in Siberian indigenous populations are located between Europeans and samples from East Asia. The same trend was revealed by us earlier in studies of polymorphisms in other functionally important genes [40,41].…”

Polymorphism rs1800795 of the IL6 gene in samples of Siberian indigenous ethnic groups

“…Conclusion: Thus, an increase in the frequency of the -174G variant of the IL6 gene in human populations is shown when moving along the Eurasian map from west to east. This in-between position of indigenous Siberian populations, as exemplified by Buryats and Teleuts, had been demonstrated earlier in the polymorphism frequencies of some other e genes [2]. Carriage of the -174G variant was shown to be associated with a high level of IL6 expression and, as a consequence, with an enhanced inflammatory response to the pathogen encounter.…”