Polymorphism of the CYP1A1*2A gene and susceptibility to lung cancer in a Brazilian population

Abstract

Objective: To estimate and compare the frequency of CYP1A1*2A gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to lung cancer risk. Methods: The study population included 200 patients with lung cancer, and the control group consisted of 264 blood donors. Genomic DNA was obtained from peripheral blood samples. The PCR-RFLP method was used for analysis of the CYP1A1*2A gene. Results: There was no statistically significant difference between the lung cancer patients and the controls in terms of the distribution of CYP1A1*2A polymorphisms (p = 0.49). A multivariate logistic regression model analysis by ethnic group revealed that, within the lung cancer group, the CYP1A1*2A genotype CC plus TC was more common among the African-Brazilian patients than among the White patients (adjusted OR = 3.19; 95% CI: 1.53-6.65). Conclusions: The CYP1A1*2A gene cannot be linked with lung cancer risk in Brazilian patients at this time. Larger epidemiologic studies are needed in order to establish whether the CC plus TC polymorphism increases the risk of lung cancer in African-Brazilians.

The role of MSP I CYP1A1 gene polymorphism in the development of uterine fibroids

“…Our results are different from those found by Honna et al (17) regarding the frequency of the MSP I CYP1A1 among Africanand European-Brazilians. We believe that this discrepancy is due to the fact that populations examined in the two studies are not similar; Honna et al (17) included patients of both genders with lung cancer in their study.…”

“…Despite the limited data available in Brazil, the frequency of the msp I CYP1A1 polymorphism was higher among AfricanBrazilians than among European-Brazilians (adjusted odds ratio 3.19; 95% confidence interval 1.53-6.65) (17).…”

“…We believe that this discrepancy is due to the fact that populations examined in the two studies are not similar; Honna et al (17) included patients of both genders with lung cancer in their study.…”

Genetic pattern of CYP1A1*2A (T>C) gene in patients with colorectal cancer in South Jakarta – Indonesia

“…CYP1A1*2A, part of CYP1A1 gene located on chromosome 15q, is a member of the CYP1 genes family with a major role in the oxidative activation and or deactivation of a wide range of xenobiotic and drug metabolism. The expression of this gene was consisting of the aryl hydrocarbon receptor and mutation on this gene reported has associated with cancer evidenced [11,12,13,14]. Two common polymorphisms in the CYP1A1 gene are a T6235C change within the 3' noncoding region of the gene (*2A, also known as the MspI restriction) and an A4889G change in the hems-binding domain of exon 7 (*2C).…”

A importância dos estudos genéticos sobre câncer de pulmão

“…In this edition of the Brazilian Journal of Pulmonology, Honma et al describe a study which evaluates the distribution of the CYP1A1*2A allele in 200 patients with lung cancer and 264 negative controls. (11) This allele was associated with greater activity of the CYP1A1 enzyme. The initial result revealed no increase in the risk of lung cancer in patients.…”