Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients

Hong, Yong-Kil; Chang, Jin Soon; Kwon, O Jung; Ham, Yoon-Ae; Choi, Ji-Hyung

doi:10.1038/emm.1998.28

Cited by 44 publications

(21 citation statements)

References 24 publications

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“…In a Swedish study (24), neither variant was associated with any subtype of lung cancer. Hong et al (25) reported a significant deficit of the CYP1A1*2C polymorphism in Korean lung cancer cases compared with controls, although notably genotypes were not in HardyWeinberg equilibrium, even in controls, making this result difficult to interpret. Studies of non-Asians conducted in America and Europe have been generally negative with few exceptions (26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 90%

GSTM1andCYP1A1Polymorphisms, Tobacco, Air Pollution, and Lung Cancer: A Study in Rural Thailand

Pisani

Srivatanakul

Randerson-Moor

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Objectives: The Lampang Province is situated in the northern region of Thailand. Incidence rates of lung cancer are high for Asian standards, particularly in women. This study was conducted to quantify the risk of lung cancer associated with exposures prevalent in the area and to investigate possible interactions with genetic susceptibility. The presence of several large open-cast coal mines from 1955 close to electricity-generating plants was a particular focus of concern. Methods: Two-hundred and eleven cases of primary lung cancers diagnosed in 1993 to 1995 and residents in the province were recruited at the Lampang Provincial Hospital (main referral center for treatment of the disease). Two sets of controls, frequency-matched to the cases by sex and age, were recruited (a) from the resident population (202 interviewed) and (b) from patients admitted to the hospital for diseases predominantly unrelated to tobacco smoking (211 interviewed). Sociodemographic information, complete residential history, and characteristics of the household (place of cooking, cooking fuel, and heating fuels), occupational history, and history of tobacco smoking were obtained by interview. Cases and controls (f50% of the populationbased series) provided a blood sample. A point source air pollution exposure index was calculated for each village/ township reported in residential histories based on the linear distance from the Mae Moh Center (the area of the electricity-generating plants), the year-specific gaseous (SO 2 and NO 2 ) or total suspended particulate emissions from the Mae Moh Power Plant, and the percentage of wind from the center. Odds ratios (OR) for the disease associated with categorical variables were estimated within unconditional logistic regression. Extraction of genomic DNA and genotyping of variants in CYP1A1 and GSTM1 were conducted to assess the extent of modification of risk by these genes that are involved in the metabolism of polycyclic aromatic hydrocarbons, a common component of the exposures. Results: Overall, there was no evidence of relevant differences in the socioeconomic level of the three groups. The two control sets were similar with respect to lifelong tobacco habit and were subsequently pooled in analyses. Neversmokers were 7% of men and 33% of women. Smoking of local traditional products unfiltered and high in tar content is a common habit in the rural female population. ORs associated with smoking increased with duration of the habit and average daily amount, being 4.9 [95% confidence interval (95% CI), 2.5-9.7] for smokers of z7 cigarettes/d and 3.3 (95% CI, 1.7-6.2) for duration of 41 years or longer compared with nonsmokers. Smoking of local products was associated with an independent OR of 3.1 (95% CI, 1.7-5.6) adjusted for lifelong cumulative amount of tobacco smoked. Although most smokers had the habit for at least 16 years, the daily consumption was low compared with Western standards. Other potential sources of exposure to lung carcinogens (emission from the power-generating pla...

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Section: Discussionmentioning

confidence: 90%

GSTM1andCYP1A1Polymorphisms, Tobacco, Air Pollution, and Lung Cancer: A Study in Rural Thailand

Pisani

Srivatanakul

Randerson-Moor

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…There has been one report for genotype frequency of MspI polymorphism in Korean population (Hong et al, 1998). Hong et al (1998) reported a minor allele frequency of 0.3 for MspI polymorphism in a control group consisted with 63 subjects. Therefore, the genotype frequency of this polymorphism among Korean population needs to be confirmed in other studies.…”

Section: Discussionmentioning

confidence: 99%

Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women

Shin

Kang²,

Choi³

et al. 2007

Exp Mol Med

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Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. We evaluated the associations between two CYP1A1 polymorphisms [MspI (rs4646903); Ile462Val (rs1048943)] and breast cancer in a multicenter case-control study of 513 breast cancer cases and 447 controls in Korea. Women carrying the T allele of the CYP1A1 MspI polymorphism were found to have a 1.72-fold (95% CI 1.11-2.68) greater risk of developing breast cancer. No association was found between any CYP1A1 Ile462Val polymorphism and breast cancer. Haplotype analysis of the two loci showed that the CA haplotype was associated with the lowest risk of breast cancer, and CA/CA diplotypes were associated with a lower risk of breast cancer [OR = 0.28 (0.13-0.61)] than others/others diplotypes. Moreover, this reduced risk was more pronounced among women with a lower body mass index (BMI)

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“…An MspI polymorphic site at the 3′-flanking region of CYP1A1 gene was identified (Kawajiri et al, 1990) and this allele was called CYP1A1*2A (Cascorbi et al, 1996). It has been reported that there is an association between the CYP1A1*2A allele and lung cancer in Japanese, white, Hawaiian and Korean populations (Kawajiri et al, 1990;Xu et al, 1996;Hong et al, 1998;Le Marchand et al, 1998). However, in other studies, using populations such as Finnish, Norwegian, German and North American, the relationship between the CYP1A1*2A allele and lung cancer was not observed (Tefre et al, 1991;Hirvonen et al, 1992;Shields et al, 1993;Drakoulis et al, 1994).…”

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confidence: 99%

Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma

Lin¹,

Sl²,

Hj³

et al. 2000

Br J Cancer

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Lung cancer is the leading cause of death among cancers in Taiwan. Although the etiology of lung cancer has yet to be defined, genetic variability in activities of metabolic enzymes has been correlated with lung cancer. In the present study, the possibility of association of CYP1A1 and microsomal epoxide hydrolase ( HYL1 ) genetic polymorphisms with lung cancer was examined among 132 lung cancer patients and 259 controls in Taiwan. No significant association was observed for either CYP1A1 or HYL1 polymorphism alone and the overall incidence of lung cancer after adjusting for age, gender and smoking status. When cases were stratified according to histological type, there was significant association between CYP1A1*2A homozygote and squamous cell carcinoma (SCC) (odds ratio (OR) 2.86; 95% confidence interval (CI) 1.33–6.12). Similarly, the proportion of HYL1 genotypes corresponding to high or normal enzyme activities was higher in SCC than in controls (OR 1.96; 95% CI 1.04–3.70). A combination of susceptible CYP1A1 and HYL1 genotypes was found to be highly associated with lung cancer, especially with SCC (OR 6.76; 95% CI 2.29–19.10). Our results suggest that the combination of CYP1A1 and HYL1 polymorphisms is an important risk factor for lung SCC. © 2000 Cancer Research Campaign

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Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients

Cited by 44 publications

References 24 publications

GSTM1andCYP1A1Polymorphisms, Tobacco, Air Pollution, and Lung Cancer: A Study in Rural Thailand

GSTM1andCYP1A1Polymorphisms, Tobacco, Air Pollution, and Lung Cancer: A Study in Rural Thailand

Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women

Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma

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