Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design

Guimarães, Monick Lindenmeyer; Moreira, AS; Masucci, Maria G.

doi:10.1590/s0074-02762002000400013

Mem. Inst. Oswaldo Cruz

2002

DOI: 10.1590/s0074-02762002000400013

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Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design

Monick Lindenmeyer Guimarães

AS Moreira

Maria G. Masucci

Abstract: Most of the

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Molecular epidemiology of HIV‐1 in Santa Catarina State confirms increases of subtype C in Southern Brazil

Locateli¹,

Stoco²,

Queiroz³

et al. 2007

Journal of Medical Virology

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Recent studies have demonstrated an increased prevalence of human immunodeficiency virus type 1 (HIV-1) subtype C in southern Brazil. Although Santa Catarina State (SC) is located in this area and presents one of the country's highest incidences of HIV/AIDS, knowledge on the molecular epidemiology of HIV-1 in such State is lacking. The aim of this study was to investigate the HIV-1 molecular diversity and epidemiological profile of HIV-1-infected patients from SC. DNA samples were PCR amplified and HIV-1 subtypes were determined using both env and gag genes by direct sequencing. Phylogenetic analyses revealed that 48% were subtype C and 23% were subtype B. Possible recombinant forms were observed for both B/C (23%) and B/F (6%) subtypes. Our results, for the first time, identifies HIV-1 subtype C as a major clade circulating in SC and contributes to the understanding of HIV epidemics in the country by confirming the epidemic spread of the HIV-1 subtype C in southern Brazil.

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Molecular epidemiology of HIV‐1 in Santa Catarina State confirms increases of subtype C in Southern Brazil

Locateli¹,

Stoco²,

Queiroz³

et al. 2007

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

Anti-HIV-1 humoral immune response in Brazilian patients

Bongertz

2003

Clinical and Applied Immunology Reviews

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Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design

Abstract: Most of the

Cited by 2 publications

References 20 publications

Molecular epidemiology of HIV‐1 in Santa Catarina State confirms increases of subtype C in Southern Brazil

Molecular epidemiology of HIV‐1 in Santa Catarina State confirms increases of subtype C in Southern Brazil

Anti-HIV-1 humoral immune response in Brazilian patients

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