Polymorphism of the interleukin 1 receptor antagonist (IL1Ra) gene and placental abruption

Jääskeläinen, Ester; Keski‐Nisula, Leea; Toivonen, Sari; Paattiniemi, Eeva-Liisa; Helisalmi, Seppo; Punnonen, Kari; Heinonen, Seppo

doi:10.1016/j.jri.2008.03.003

Cited by 7 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Retroplacental clots are sometimes employed in placental abruption clinical diagnoses, and have been required to confirm placental abruption cases in some epidemiological studies, 30–32 so the limited association between placental abruption and disc‐impacting blood clots is noteworthy. It is important to distinguish the disc‐impacting blood clot construct captured by the POUCH Study pathologist from adherent retroplacental clots visualised on a freshly delivered placenta by an attending clinician.…”

Section: Discussionmentioning

confidence: 99%

Evidence of placental haemorrhage and preterm delivery

Gargano

Holzman

Senagore

et al. 2010

BJOG

View full text Add to dashboard Cite

Please cite this paper as: Gargano J, Holzman C, Senagore P, Reuss M, Pathak D, Williams M, Fisher R. Evidence of placental haemorrhage and preterm delivery. BJOG 2010;117:445–455. Objective To evaluate evidence of placental haemorrhage (PH) obtained through maternal interviews, patient charts and placental pathology examinations as potential indicators of a ‘bleeding pathway’ to preterm delivery (PTD). Design Prospective cohort. Setting Fifty‐two clinics in five communities in Michigan, USA (1998–2004). Population A subset (n = 996) of cohort participants with complete placental pathology data. Methods First‐trimester bleeding and placental abruption were ascertained by mid‐trimester interviews and chart review, respectively. Disc‐impacting blood clot was defined as a gross placental examination finding of a blood clot impacting adjacent tissue. Microscopic haemorrhage was defined as ‘high’ (top quintile) scores on an aggregate measure of placental pathology findings suggestive of atypical maternal vessel haemorrhage. These four PH indicators were compared with one another and with risk of PTD assessed by logistic regression analyses. Main outcome measures Preterm delivery and PTD subtypes (i.e. <35 weeks, 35–36 weeks; spontaneous, medically indicated) compared with term deliveries. Results Placental abruption cases had 2.3‐fold to 5.5‐fold increased odds of the other three PH indicators. Disc‐impacting blood clots and microscopic haemorrhage were associated with one another (odds ratio [OR] = 4.6), but not with first‐trimester bleeding. In a multivariable model that included all four PH indicators and confounders, risk of PTD < 35 weeks was elevated with first‐trimester bleeding (OR = 1.9 [1.0, 3.4]), placental abruption (OR = 5.2 [1.7, 16.2]), disc‐impacting blood clots (OR = 2.3 [1.0, 5.0]) and microscopic haemorrhage (OR = 2.4 [1.4, 4.2]). Conclusions Multiple clinical and subclinical PH indicators are associated with PTD, particularly early PTD.

show abstract

Section: Discussionmentioning

confidence: 99%

Evidence of placental haemorrhage and preterm delivery

Gargano

Holzman

Senagore

et al. 2010

BJOG

View full text Add to dashboard Cite

show abstract

“…45 Other previous candidate gene association studies of AP included investigations of genes in thrombophilia, rennin-angiotensin system, folate metabolism, and interleukin 1 receptor antagonist-related and oxidative stress pathways. 11,12,46–48 However, these studies were small in sample size that showed modest effects and did not validate the findings with the use of either SNPs or genetic risk scores in an independent study. Using SNPs in MB/OP genes and wGRS analysis, our team previously reported that participants (470 AP cases and 473 control subjects) in the highest quartiles of the risk score (≥10.0) had 1.9-fold (95% CI, 1.2–3.1) higher odds of AP (≤8.0) compared with participants in the lowest risk score group.…”

Section: Commentmentioning

confidence: 91%

Abruptio placentae risk and genetic variations in mitochondrial biogenesis and oxidative phosphorylation: replication of a candidate gene association study

Workalemahu

Enquobahrie

Gelaye

et al. 2018

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

In this study, we replicated previous findings and provide strong evidence for DNA variants that encode for genes that are involved in mitochondrial biogenesis and oxidative phosphorylation pathways, which confers risk for abruptio placentae. These results shed light on the mechanisms that implicate DNA variants that encode for proteins in mitochondrial function that are responsible for abruptio placentae risk. Therapeutic efforts to reduce risk of abruptio placentae can be enhanced by improved biologic understanding of maternal mitochondrial biogenesis/oxidative phosphorylation pathways and identification of women who would be at high risk for abruptio placentae.

show abstract

“…The observation that thrombophilia has a high prevalence among women with placental abruption supports the idea of a genetic background for this condition (Refs 104, 105, 106). However, there are conflicting genetic studies involving candidate gene polymorphisms (Refs 107, 108). A recent meta-analysis identified the most frequent gene polymorphisms associated with placental abruption (Ref.…”

Section: Genetic Risk Factors For Placental Abruptionmentioning

confidence: 99%

Novel insights into molecular mechanisms of abruption-induced preterm birth

Buhimschi

Schatz

Krikun

et al. 2010

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

Preterm birth (PTB) complicates more than 12% of all deliveries. Despite significant research, the aetiology of most cases of PTB remains elusive. Two major antecedents of PTB, intra-amniotic infection and decidual haemorrhage (abruption), can exhibit dissimilar demographic and genetic predispositions, despite sharing common molecular and cellular pathways. The use of high-throughput, high-dimensional technologies reveals substantial crosstalk between the coagulation and inflammation pathways. Tissue factor, thrombin and cytokines are key mediators of this crosstalk. Abruptions are associated with excess thrombin generated from decidual-cell-expressed tissue factor. Although thrombin is a primary mediator of the coagulation cascade, it can also promote inflammation-associated PTB by enhancing expression of matrix metalloproteinase and neutrophil-chemoattracting and -activating chemokines. Here, we provide novel insights into the molecular mechanisms and pathways leading to PTB in the setting of placental abruption.

show abstract

Polymorphism of the interleukin 1 receptor antagonist (IL1Ra) gene and placental abruption

Cited by 7 publications

References 27 publications

Evidence of placental haemorrhage and preterm delivery

Evidence of placental haemorrhage and preterm delivery

Abruptio placentae risk and genetic variations in mitochondrial biogenesis and oxidative phosphorylation: replication of a candidate gene association study

Novel insights into molecular mechanisms of abruption-induced preterm birth

Contact Info

Product

Resources

About