Polymorphism rs4934 of &lt;i&gt;SERPINA3&lt;/i&gt; and Sporadic Intracranial Aneurysms in the Chinese Population

Liu, Wei; Zhu, Yufang; Ge, Mingtao; Pang, Qi; Yu, Yanbing

doi:10.1159/000256649

Cited by 10 publications

(4 citation statements)

References 56 publications

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“…A single nucleotide polymorphism (SNP) (rs4934) is located in the signal peptide region (at codon 15) in exon 2. It has been postulated that this genotype affects the expression of serpinA3 protein (12)(13)(14). Moreover, studies have proven that this genetic variant is a risk factor for aneurysmal subarachnoid hemorrhage in a Polish (12), but not in a Chinese (13) or Japanese (14) population.…”

Section: Introductionmentioning

confidence: 99%

Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas

et al. 2011

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Abstract. Proteases facilitate a number of steps in cancer progression. The serine protease inhibitors (serpins) are a protein superfamily with inhibitory activity against proteases. One of these proteases, serpinA3, appears to have a multifaceted role and is associated with inflammatory reactions, Alzheimer's disease, malignant melanoma and gastric cancer. To gain insight into the potential effect of serpinA3 on colorectal cancer (CRC) we determined whether serpinA3 is altered in colorectal tissue or plasma in CRC patients. Collectively, by using ELISA we noted a significantly lower serpinA3 level in cancer tissue compared to paired normal tissue. Moreover, the tumour serpinA3 level tended to be higher in disseminated disease as compared to localised disease. No significant difference in the plasma levels of serpinA3 was noted in the patients when compared to the controls. However, plasma serpinA3 and C-reactive protein (marker of inflammation) in the CRC patients and controls were significantly positively correlated. To confirm and detect localization of serpinA3 expression, immunohistochemistry was performed. Immunohistochemistry showed heterogeneous immunoreactivity in epithelial cells in the cancer and normal tissue and extracellular staining within bands of stroma as well as in some stromal cells. A Taq Man system was used to investigate a single nucleotide polymorphism (rs4934) in the serpinA3 signal sequence gene with supposed effect on serpinA3 secretion and expression. No significant difference was observed between CRC and control subjects regarding genotype and allelic distributions, nor were associations noted between clinical characteristics and serpinA3 levels. In conclusion, an altered serpinA3 concentration in CRC tissue may be a potential biomarker in CRC progression. SerpinA3 concentrations in plasma appear to be correlated with systemic inflammation, but do not appear to be specific to CRC patients. Further studies are warranted to improve our understanding of the role of serpinA3 in CRC.

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Section: Introductionmentioning

confidence: 99%

Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas

et al. 2011

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“…We identified a subnetwork with SERPINA3 being the key molecule which is shown in Figure 3. SERPINA3 is known to be associated with several neurological disorders including Parkinson's disease [42], Alzheimer's disease [43], schizophrenia and cerebrovascular disease [44]. Notably, we observed GFAP and CHI3L1 which were upregulated in TBM to be part of this subnetwork.…”

Section: Biological Network Data Analysismentioning

confidence: 59%

Gene Expression Profiling of Tuberculous Meningitis

Kumar

Venugopal

Selvan

et al. 2011

JPB

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Gene expression profiling studies have previously been performed on CSF or blood of patients with TBM [16,17]. In the present study, we used whole genome DNA microarrays for investigating changes at the transcriptome level in infected brain tissues from TBM cases that were confirmed by autopsy as compared to uninfected brain tissues from controls. Further, we performed immunohistochemical validation of some of the differentially expressed genes identified from

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“…Intracranial aneurysm (IA) occurs in $2% of the population worldwide, meaning that over 20 million people in China will experience an IA. 1 It is $1.6-times more common in women than in men, and the majority of ruptured IAs is observed in people between the ages of 40 and 60 years. 2 Rupture of an IA accounts for >90% of subarachnoid haemorrhage (SAH) cases.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion gene polymorphism and risk of intracranial aneurysm in a Chinese population

Liu

et al. 2013

J Int Med Res

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The relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphisms and intracranial aneurysm (IA) has been studied in Caucasian and Japanese populations. The present study aimed to investigate this association in a Chinese population. Methods: Patients with confirmed IA and age-and sex-matched control subjects without evidence of IA were enrolled. ACE I/D gene polymorphisms were analysed using polymerase chain reactionrestriction fragment length polymorphism. Results: A total of 220 patients with IA and 220 matched controls were enrolled. In the IA group, 64, 106 and 50 patients were of the II, ID and DD genotypes, respectively, compared with 44, 99 and 77 subjects in the control group. The ACE DD genotype and D allele frequencies were significantly lower in the IA group compared with the control group. There were no statistically significant differences in the site, shape, size and Fisher Grade of aneurysms between genotypes in patients with IA. Conclusion: The ACE DD genotype may be a protective factor for IA in a Chinese population.

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Polymorphism rs4934 of <i>SERPINA3</i> and Sporadic Intracranial Aneurysms in the Chinese Population

Cited by 10 publications

References 56 publications

Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas

Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas

Gene Expression Profiling of Tuberculous Meningitis

Angiotensin-converting enzyme insertion/deletion gene polymorphism and risk of intracranial aneurysm in a Chinese population

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