Polymorphisms in alcohol and tobacco metabolism genes in head and neck cancer in the <scp>B</scp>asque <scp>C</scp>ountry

Bediaga, Naiara G.; Marichalar-Mendía, Xabier; Rey-Barja, Natalia; Setien-Olarra, Amaia; González-García, José Ángel; Pancorbo, Marian M. de; Aguirre‐Urízar, José Manuel; Acha-Sagredo, Amelia

doi:10.1111/jop.12305

Cited by 16 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We selected 37 SNPs with a minor allele frequency (MAF) > 5% in the HapMap Han Chinese population in Beijing that were previously associated with head and neck cancer [22–24] for genotyping. Genomic DNA was extracted from peripheral blood leukocytes using GoldMag ® nanoparticles (GoldMag Ltd. Xi'an, China) according to the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer

Zhang

Jin

et al. 2016

Oncotarget

View full text Add to dashboard Cite

In this study, we assessed the association between single nucleotide polymorphisms (SNPs) in candidate genes and the prognosis of laryngeal cancer (LC) patients. Thirty-seven SNPs in 26 genes were genotyped in 170 male Han Chinese patients with LC. The effects of the candidate genes on the prognosis of LC patients were evaluated using Kaplan-Meier curves and Cox proportional hazards regression models. The GA genotype of rs1229984 (hazard ratio [HR], 0.537; 95% confidence interval [CI], 0.340–0.848; p = 0.008) in alcohol dehydrogenase 1B (ADH1B), and the AA genotype of rs9929218 (HR, 6.074; 95% CI, 1.426–25.870; p = 0.015) in CDH1 were associated with overall survival. Our data suggest that polymorphisms in ADH1B and CDH1 may be prognostic indicators in LC.

show abstract

Section: Methodsmentioning

confidence: 99%

ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer

Zhang

Jin

et al. 2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…A number of studies have demonstrated the correlation between ALDH2 gene or SOD2 gene polymorphisms and susceptibility to HNSCC [12][13][14][15][16][17]. However, the expression pattern of these two genes in HNSCC patients in terms of the amount of alcohol drinking and tobacco smoking has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma

Lee

Kim

et al. 2017

World J Surg Onc

View full text Add to dashboard Cite

Background: This study aims to determine the relationship between expression levels of ALDH2 and SOD2 genes and clinical parameters such as alcohol drinking, tobacco smoking, primary site of HNSCC, and human papilloma virus (HPV) state. Methods: Gene expression data were obtained from gene expression omnibus (GEO accession number: GSE65858). Clinical data (N = 270) including survival result, gender, age, TNM stage, primary site of HNSCC, HPV status, alcohol drinking, and tobacco smoking habit were analyzed according to gene expression pattern. Results: ALDH2 gene was expressed in low levels in patients with heavy alcohol consumption. It was expressed in high (p = 0.01) levels in patients with no or light alcohol consumption. ALDH2 gene was also expressed in low levels in patients with oral cavity cancers or hypopharynx cancers. However, ALDH2 gene was expressed in high (p = 0.03) levels in patients with oropharyngeal cancers or laryngeal cancers. HPV-positive patients were found to have high (p = 0.02) expression levels of ALDH2. SOD2 gene was expressed in high (p = 0.005) levels in patients who had greater mean pack-year of tobacco smoking. Based on log rank test, the group of patients with high expression of ALDH2 showed better (p = 0.002) clinical results than those with low expression of ALDH2. Difference of survival results between ALDH2 high-expressed group and ALDH2 low-expressed group was validated in another cohort (GSE39368, N = 138). Conclusions: Heavy alcohol drinking downregulates ALDH2 gene expression level. Heavy smoking up-regulates SOD2 gene expression level in patients with head and neck squamous cell carcinoma. The group of patients with low expression levels of ALDH2 showed significantly poorer survival results compared to those with high expression levels of ALDH2.

show abstract

“…Therefore, identification of SNPs, which serve as genetic susceptibility markers of tumors, has become a recent research interest. According to available evidence, SNPs in biotransformation enzymes (Shukla et al, 2012 ), DNA repair genes (Li et al, 2016 ), apoptotic pathways (Ma et al, 2011 ), alcohol metabolism (Bediaga et al, 2015 ), and immune inflammatory cytokines (Singh et al, 2015 ; Ma and Zhou, 2016 ) could affect the risk of HNC. Furthermore, these SNPs may also play a role in prognostication and may serve as a predictive tool in making treatment decisions for HNC (Zafereo et al, 2009 ; Lundberg et al, 2012 ; Sivadas et al, 2013 ; Zou et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Association between TGF-β1 Polymorphisms and Head and Neck Cancer Risk: A Meta-Analysis

et al. 2017

View full text Add to dashboard Cite

Background and Objective: Studies have been conducted to explore the association between the single nucleotide polymorphisms (SNPs) in transforming growth factor beta 1 (TGF-β1) and head and neck cancer (HNC) susceptibility, however the findings are still inconclusive. Therefore, we conduct this meta-analysis to quantitatively assess the association.Methods: Embase and PubMed were searched for all eligible clinical studies. The odds ratio (OR) and 95% confidence interval (CI) of each study were pooled to estimate the association between SNPs in the TGF-β1 and the HNC risk. Subgroup analysis was used to explore whether particular characteristics were related to the value of overall ORs and 95% CIs.Results: Seven case-control studies, including three SNPs (−509C/T, 869T/C, and 915G/C), were examined. Overall, this meta-analysis failed to identify a significant association between TGF-β1−509C/T, 915G/C polymorphism and HNC risk in any models. As for the 869T/C polymorphism, significant associations were observed in the allelic model (C vs. T: OR = 1.351, 95%CI: 1.030–1.772), the homozygote model (CC vs. TT: OR = 1.585, 95%CI: 1.026–2.449) and the dominant model (CT/CC vs. TT: OR = 1.398, 95%CI: 1.008–1.937). This polymorphism was also found in the Asian group as well (C vs. T: OR = 1.400, 95%CI: 1.003–1.956, CC vs. TT: OR = 1.814, 95%CI: 1.018–3.233).Conclusion: Meta-analysis failed to show a statistical association between TGF-β1−509C/T, 915G/C polymorphism, and HNC risk in any genetic models. However, it was found that TGF-β1 869C/T polymorphism may be involved in susceptibility to HNC, especially in Asian patients. However, given the limitations of this meta-analysis, further well-designed studies are required in the future.

show abstract

Polymorphisms in alcohol and tobacco metabolism genes in head and neck cancer in the Basque Country

Abstract: The identified genotypic variations in alcohol and tobacco metabolizing genes only by themselves do not seem to be responsible for the higher incidence of HNSCC observed in the Basque Country.

Cited by 16 publications

References 23 publications

ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer

ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer

Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma

Association between TGF-β1 Polymorphisms and Head and Neck Cancer Risk: A Meta-Analysis

Contact Info

Product

Resources

About