2003
DOI: 10.1093/carcin/bgh002
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Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study

Abstract: Genetic polymorphisms in double-strand break repair genes may influence DNA repair capacity and, in turn, confer predisposition to breast cancer. We prospectively assessed the associations of candidate polymorphisms G31479A (R188H) in XRCC2, A4541G (5'-UTR), A17893G (IVS5-14) and C18067T (T241 M) in XRCC3, and C299T (5'-UTR) and T1977C (D501D) in Ligase IV with breast cancer risk in a nested case-control study within the Nurses' Health Study (incident cases, n=1004; controls, n=1385). We observed no overall as… Show more

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Cited by 81 publications
(87 citation statements)
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References 33 publications
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“…Out of the 55 abstracts retrieved through the search criteria, 25 were irrelevant, four articles [8][9][10][11] were excluded because they were conducted on overlapping populations with other eligible studies [2,3,5,12] (these excluded articles represent smaller studies performed on subsets of larger eligible studies), one study [13] was excluded given that it has not included controls in its study design, three articles [4,14,15] were reviews/meta-analyses, and three studies [16][17][18] were excluded due to other reasons (two of them [16,17] were excluded due to reporting reasons, i.e. no reporting of the relevant genotype frequencies, whereas the other [18] was excluded for examining the association between other XRCC3 polymorphisms and premenopausal breast cancer risk).…”
Section: Resultsmentioning
confidence: 99%
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“…Out of the 55 abstracts retrieved through the search criteria, 25 were irrelevant, four articles [8][9][10][11] were excluded because they were conducted on overlapping populations with other eligible studies [2,3,5,12] (these excluded articles represent smaller studies performed on subsets of larger eligible studies), one study [13] was excluded given that it has not included controls in its study design, three articles [4,14,15] were reviews/meta-analyses, and three studies [16][17][18] were excluded due to other reasons (two of them [16,17] were excluded due to reporting reasons, i.e. no reporting of the relevant genotype frequencies, whereas the other [18] was excluded for examining the association between other XRCC3 polymorphisms and premenopausal breast cancer risk).…”
Section: Resultsmentioning
confidence: 99%
“…no reporting of the relevant genotype frequencies, whereas the other [18] was excluded for examining the association between other XRCC3 polymorphisms and premenopausal breast cancer risk). As a result, 19 case-control articles [2,3,5,12,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]] (23 case-control studies, considering that Breast Cancer Association Consortium has more than one studies included) were included in this meta-analysis; 20 case-control studies on non-Chinese subjects (19,575 cases and 21,125 controls) and three case-control studies [3,24,29] on Chinese subjects (1,216 cases and 1,112 controls). Table 1 presents in detail the results of the meta-analysis.…”
Section: Resultsmentioning
confidence: 99%
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“…This variant allele has also been reported to confer a significantly decreased susceptibility to bladder (35), invasive ovarian (21), and upper aerodigestive (37) cancers. However, a few studies have shown no such association with cancer (37)(38)(39)(40). Factors such as study design, sample size, cancer sites, population heterogeneity, and the biological complexity of low-penetrance cancer susceptibility genes may explain the observed discrepancies.…”
Section: Discussionmentioning
confidence: 99%
“…It is well known that high consumption of fruit and vegetable has been thought to provide protection against many types of cancer, including BC [15]. Their consumption could decrease BC risk through several mechanisms, mainly linked to the abundance of antioxidants contained therein, which also contain biocompounds such as isoflavones, lignans and indoles [1,2,64]; all of these substances have been convincingly shown to have anticarcinogenic properties and strong effects on estrogen metabolism (as reviewed in [38]), even though to date there are contrasting findings [35].It is becoming clear that relationships between diet and breast cancer aetiology are extremely complex, and that the impact of micro-and macro-nutrients on BC risk are dependent in part on genetic factors [20,21,58]. Being the application of molecular epidemiology to nutrition and breast cancer in its infancy, recent studies have highlighted the importance of investigations of diet, genetic variability and breast cancer risk using a fluid non-invasively collected from breast ducts (nipple aspirate fluid, NAF), a fluid that mirrors the microenvironment of the breast tissue during physio-pathological conditions [29,43,44,56].…”
mentioning
confidence: 99%